Combination of epidermal keratinocyte–melanocyte cells suspension and microneedling: Safe surgical approach in vitiligo

Nilforoushzadeh, Mohammad Ali; Nouri, Maryam; Alavi, Shiva; Sadatiseyedmahaleh, Ashrafalsadat; Razzaghi, Zahra; Darian, Ebrahim Khodaverdi; Afzali, Hamideh; Mahmoudbeyk, Mona; Behrangi, Elham; Nikkhah, Nahid; Peyrovan, Aisan; Zare, Samad

doi:10.1111/jocd.14987

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…In a recent study by Nilforoushzadeh and colleagues, 23 who performed MKCST to treat vitiligo, patients underwent microneedling treatment after spraying the cells. The color alteration between the lesion area and normal skin was significantly reduced after the procedure.…”

Section: Discussionmentioning

confidence: 99%

Dermabrasion Versus Microneedling in Transplantation of Autologous Noncultured Melanocyte–Keratinocyte Cell Suspension in Patients With Vitiligo

Hasan¹,

Almohsen²,

Nasr³

et al. 2023

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BACKGROUNDAutologous noncultured melanocyte–keratinocyte transplantation is one of the procedures used to treat stable vitiligo with varying reported results. Recipient site preparation is one of the variables that could affect repigmentation outcomes.OBJECTIVETo assess the effectiveness of transplanting autologous melanocyte–keratinocyte suspension in patients with stable vitiligo and to compare recipient site preparation using dermabrasion versus microneedling.METHODSFrom March 2020 to September 2022, this randomized comparative study included 40 patients with 40 stable vitiligo lesions managed by suspension transplants of melanocytes. Patients were divided into 2 groups: group A, where the recipient site was prepared using dermabrasion, and group B, which was done by microneedling. The assessment was performed 3 months after the treatment based on the degree of repigmentation (excellent, ≥90%; good, 50%–89%; fair, 20%–49%; and poor response, <20%).RESULTSBoth modalities resulted in effective repigmentation, but the dermabrasion group showed a statistically significant improvement and a satisfactory repigmentation rate.CONCLUSIONAutologous melanocyte transplantation is a safe and effective treatment method for stable vitiligo lesions that have not responded to other therapies. When compared with microneedling, dermabrasion produced better outcomes for recipient site preparation.

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Section: Discussionmentioning

confidence: 99%

Dermabrasion Versus Microneedling in Transplantation of Autologous Noncultured Melanocyte–Keratinocyte Cell Suspension in Patients With Vitiligo

Hasan¹,

Almohsen²,

Nasr³

et al. 2023

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“… 4 Vitiligo is associated with pigment degradation in skin melanocyte cells. 5 The autologously transplanted dermis-derived cells contribute to the synthesis of melanin. 6 Tissue grafting techniques and cellular grafting techniques have been used.…”

Section: Introductionmentioning

confidence: 99%

Transversely Sectioned Mini-Punch Grafting: A Novel Technique for Effective Treatment of Hairline Vitiligo

Zhou¹,

Wang²,

Yu³

et al. 2023

CCID

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Objective Hairline vitiligo is a special area. Hairy areas within the hairline often require repigmentation and regrowing hair shafts. The face and forehead outside the hairline do not require regrowing hair shafts, only repigmentation. To tackle this issue, we modified the conventional mini-punch grafting with a combined application of mini-punch grafting and follicular hair transplant. Methods Five patients with localized hairline stable vitiligo aged 26–32 years old had a history of nonsurgical treatments for at least 3 months and without progress. The grafts were transversely sectioned. The intact half follicles were preserved below the cross-section. Sectioned grafts were placed into the chambers for transplanting with forceps. Results The treatment using transversely sectioned mini-punch grafting with the patient was performed for all five patients, and the results were satisfactory. In the area of the forehead outside the hairline with the sectioned mini-punch grafting above the cross-section, hair loss and repigmentation were observed. In the area of the hairy areas within the hairline, growing hair shafts and repigmentation were observed, without hair loss. Conclusion Our report can help to manage hairline vitiligo or hairy areas vitiligo. This method can be considered a potential method for the treatment of hairline vitiligo, thus providing a simple solution to complex problems.

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Report of novel treatment of segmental vitiligo using combined microneedling and topical ruxolitinib

Abdin,

Kaiser,

Issa

2023

JEADV Clinical Practice

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Vitiligo is a chronic disease which manifests as patchy loss of skin pigmentation. It can be classified into two main types: segmental and nonsegmental. The condition can result in significant negative psychosocial effects, especially in skin of colour patients. These implications are particularly important in the social development of children and adolescents. As such, rapid‐acting, effective therapeutic options should be pursued when treating these patients. Topical ruxolitinib is the only approved drug for the treatment of vitiligo. Other procedural therapeutic options have also been explored including microneedling both alone and in conjunction with topical agents. Microneedling is thought to stimulate repigmentation through the induction of cytokines and growth factors which activate melanocytes and their precursors as well as through the creation of microchannels which allow for enhanced topical drug delivery. Its efficacy has been described in nonsegmental vitiligo cases, but its utility in segmental vitiligo has not been consistently characterised in the literature. We describe the first case of segmental vitiligo treated with combined microneedling and topical ruxolitinib in a skin of colour adolescent patient and review the purported mechanism of action of treatment.

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Combination of epidermal keratinocyte–melanocyte cells suspension and microneedling: Safe surgical approach in vitiligo

Cited by 3 publications

References 28 publications

Dermabrasion Versus Microneedling in Transplantation of Autologous Noncultured Melanocyte–Keratinocyte Cell Suspension in Patients With Vitiligo

Dermabrasion Versus Microneedling in Transplantation of Autologous Noncultured Melanocyte–Keratinocyte Cell Suspension in Patients With Vitiligo

Transversely Sectioned Mini-Punch Grafting: A Novel Technique for Effective Treatment of Hairline Vitiligo

Report of novel treatment of segmental vitiligo using combined microneedling and topical ruxolitinib

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