Combination of dietary factors in relation to breast‐cancer occurrence

Veer, P. van ‘t; Leer, E.M. van; Rietdijk, A.; Kok, F.J.; Schouten, E.G.; Hermus, R.J.J.; Sturmans, F.

doi:10.1002/ijc.2910470503

Cited by 81 publications

(19 citation statements)

References 18 publications

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“…Intriguingly, in traditional Ajurvedic medicine, guggul leaf (Commiphora mukul) extract is not only used to decrease cholesterol levels but also has been used to treat cancer (45,46). Moreover, recent epidemiological studies suggest that breast cancer rates are lower in regions with high consumption of low-fat fermented milk or soy products (47,48). Results of other studies suggest that this may be attributable to the effect of Lactobacillus processing bile acids (49,50).…”

Section: Discussionmentioning

confidence: 99%

Lipids isolated from bone induce the migration of human breast cancer cells

Silva

Dasgupta

Wang

et al. 2006

Journal of Lipid Research

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Bone is the most common site to which breast cancer cells metastasize. We found that osteoblast-like MG63 cells and human bone tissue contain the bile acid salt sodium deoxycholate (DC). MG63 cells take up and accumulate DC from the medium, suggesting that the bone-derived DC originates from serum. DC released from MG63 cells or bone tissue promotes cell survival and induces the migration of metastatic human breast cancer MDA-MB-231 cells. The bile acid receptor farnesoid X receptor (FXR) antagonist Z-guggulsterone prevents the migration of these cells and induces apoptosis. DC increases the gene expression of FXR and induces its translocation to the nucleus of MDA-MB-231 cells. Nuclear translocation of FXR is concurrent with the increase of urokinase-type plasminogen activator (uPA) and the formation of F-actin, two factors critical for the migration of breast cancer cells. Our results suggest a novel mechanism by which DC-induced increase of uPA and binding to the uPA receptor of the same breast cancer cell selfpropel its migration and metastasis to the bone.-Silva, J., S. Dasgupta, G. Wang, K. Krishnamurthy, E. Ritter, and E. Bieberich. Lipids isolated from bone induce the migration of human breast cancer cells. The migration of cancer cells is a key factor in metastasis, which is a multistep event that involves the interaction of host and tumor tissue. Bone is the most common site to which breast cancer cells metastasize (1, 2). The mechanism underlying this specific metastatic behavior is not completely understood. Recently, we reported that oxygenated derivatives of cholesterol (oxysterols) synthesized and released by human osteoblast-like MG63 cells induce the migration of nonmetastatic human breast cancer MCF-7 cells (3). Bile acids, another species of oxygenated cholesterol, have long been implicated in the tumorigenesis of colorectal cancer (4, 5). Recent studies have shown that an increased concentration of bile acids in breast cyst fluid is indicative of a higher risk of developing breast cancer (6, 7). It remained to be elucidated, however, which cell signaling pathways for tumorigenesis and breast cancer cell migration are triggered by bile acids.The secondary bile acid deoxycholic acid or its salt deoxycholate (DC) is synthesized by intestinal bacteria and transported to the liver and other tissues by the serum (8-11). The specific enrichment of deoxycholic acid and other bile acids in breast cyst fluid shows that tissues other than liver can take up and accumulate bile acids from the serum (7,12,13). Bile acids bind to the nuclear receptor farnesoid X receptor (FXR) and activate a variety of genes involved in cholesterol metabolism and transport (14-17). FXR is expressed in colorectal tumor cells; however, it is not clear how bile acid-induced activation of FXR triggers cancerogenesis (18). In this study, we show for the first time that bone tissue and MG63 cells contain DC. We provide evidence that DC is taken up from the medium and can be released at a concentration that induces the mi...

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Section: Discussionmentioning

confidence: 99%

Lipids isolated from bone induce the migration of human breast cancer cells

Silva

Dasgupta

Wang

et al. 2006

Journal of Lipid Research

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“…In fact, a case -control study found a synergistic protective effect of fibre and fermented milk on breast cancer risk. The study concluded that a dietary pattern combining low fat, high fibre and fermented milk might provide substantial protection against breast cancer (van't Veer et al, 1991). Although the extended model was adjusted for these nutrients, residual confounding might remain.…”

Section: Discussionmentioning

confidence: 99%

Intakes of plant foods, fibre and fat and risk of breast cancer – a prospective study in the Malmö Diet and Cancer cohort

et al. 2004

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The objective of this study was to investigate prospectively the associations between intakes of plant foods, fibre and relative fat and risk of breast cancer in a subsample of 11 726 postmenopausal women in the Malmö Diet and Cancer cohort. Data were obtained by an interview-based diet history method, a structured questionnaire, anthropometrical measurements and national and regional cancer registries. During 89 602 person-years of follow-up, 342 incident cases were documented. Cox regression analysis examined breast cancer risks adjusted for potential confounders. High fibre intakes were associated with a lower risk of postmenopausal breast cancer, incidence rate ratio ¼ 0.58, 95% CI: 0.40, 0.84, for the highest quintile of fibre intake compared to the lowest quintile. The combination high fibre -low fat had the lowest risk when examining the effect in each cell of cross-classified tertiles of fibre and fat intakes. An interaction (P ¼ 0.049) was found between fibre-and fat-tertiles. There was no significant association between breast cancer risk and intakes of any of the plant food subgroups. These findings support the hypothesis that a dietary pattern characterised by high fibre and low fat intakes is associated with a lower risk of postmenopausal breast cancer.

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“…An early population-based case-control study in the Netherlands suggested that women who consumed relatively high levels of dietary calcium and fiber might have a decreased risk of breast cancer (55). However, this study was relatively small and failed to control for potential confounding factors other than age and fat intake.…”

Section: Anticarcinogenic Propertiesmentioning

confidence: 91%

Vitamin D, Calcium, and Breast Cancer Risk: A Review

Cui

Rohan

2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

156

152

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Vitamin D and calcium are metabolically interrelated and highly correlated dietary factors. Experimental studies have shown their anticarcinogenic effects due to their participation in regulating cell proliferation, differentiation, and apoptosis in normal and malignant breast cells. Given the emerging interest in their potential roles in the etiology of breast cancer, we review the current epidemiologic literature on dietary and/or supplemental intakes of vitamin D, endogenous circulating levels of vitamin D, and dietary and/or supplemental intakes of calcium in relation to breast cancer risk. To place these studies in context, we also provide a brief review of other supporting epidemiologic evidence. Despite inconsistent results from the epidemiologic studies, several lines of evidence suggest that vitamin D and calcium may be involved in the development of breast cancer. Specifically, (a) there is some epidemiologic evidence for inverse associations between vitamin D and calcium intakes and breast cancer; (b) serum, plasma, and/or blood levels of vitamin D metabolites have been inversely associated with breast cancer risk in some studies; (c) high sunlight exposure, presumably reflecting vitamin D synthesis in the skin, has been associated with a reduced risk of breast cancer; (d)

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Combination of dietary factors in relation to breast‐cancer occurrence

Cited by 81 publications

References 18 publications

Lipids isolated from bone induce the migration of human breast cancer cells

Lipids isolated from bone induce the migration of human breast cancer cells

Intakes of plant foods, fibre and fat and risk of breast cancer – a prospective study in the Malmö Diet and Cancer cohort

Vitamin D, Calcium, and Breast Cancer Risk: A Review

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