Combination of chemistry and material science to overcome health problems

Karges, Johannes

doi:10.1016/j.bsheal.2022.03.004

Cited by 15 publications

(8 citation statements)

References 12 publications

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“…Nanomaterials can encapsulate promising drug candidates and allow effective cellular uptake and accumulation at target sites to overcome the limitations of medicinal chemistry. [ 23 ] In addition, for nanomaterials, the surface charge also affects the pharmacokinetic properties. [ 24 ] Therefore, we examined the distribution of CuET‐Lipid@Cela resulting from the increased zeta potential after the addition of CuET into the Lipid materials.…”

Section: Resultsmentioning

confidence: 99%

Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2‐Mediated Unfolded Protein Reaction Activation

Liu

Zhang

et al. 2023

Adv Healthcare Materials

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Chemotherapy‐induced adaptive resistance is a significant factor that contributes to low therapeutic efficacy in tumor cells. The unfolded protein response (UPR) is a key mechanism in the development of drug resistance and serves as a critical reactive system for endoplasmic reticulum stress. Cu(II) can reduce the abundance of 60S ribosomal subunits and inhibit rRNA processing, leading to a decrease in the translation efficiency of the GRP78/BiP mRNA, which serves as a primary sensor for UPR activation. In this study, CuET‐Lipid@Cela, composed of CuET and tripterine (Cela), demonstrates a significant synergistic antitumor effect on cholangiocarcinoma (CCA) cells. RNA‐Seq is used to investigate the underlying mechanism, which suggests that the transmembrane protein 2 (TMX2) gene may be crucial in Cu(II) regulation of UPR by inhibiting the activation of GRP78/BiP and PERK/eIF2α. The synergistic antitumor efficacy of CuET‐Lipid@Cela via inhibition of TMX2 is also confirmed in a myrAKT/YapS127A plasmid‐induced primary CCA mouse model, providing new insights into the reversal of acquired chemotherapy‐induced resistance in CCA.

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Section: Resultsmentioning

confidence: 99%

Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2‐Mediated Unfolded Protein Reaction Activation

Liu

Zhang

et al. 2023

Adv Healthcare Materials

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“…Recently, a novel concept of biosafety materials has been proposed, 8,9 which advocates the development of innovative materials for the antibacterial field. 10,11 Several antibacterial materials have been successfully synthesized and even applied in clinical settings, 12 including but not limited to natural, inorganic, and organic antibacterial materials. [13][14][15] These materials are easily obtainable and possess commendable bactericidal capabilities, owing to continuous improvements.…”

Section: Introductionmentioning

confidence: 99%

Design of biodegradable polyurethanes and post-modification with long alkyl chains via inhibiting biofilm formation and killing drug-resistant bacteria for the treatment of wound bacterial infection

Gu,

Ren,

Han

et al. 2024

Biomater. Sci.

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“…Biosafety is a crucial consideration for in vivo administration. , To assess the biosafety, NPt IV @siXkr8 and other control Pt-containing formulations were intravenously administered three times at a dose of 3.5 mg/kg body weight and an interval of 3 days to balb/c mice. Blood physiological and biochemical parameters were then evaluated 10 days after first administration to ensure biosafety.…”

Section: Introductionmentioning

confidence: 99%

Nuclear-Targeting Lipid Pt^IV Prodrug Amphiphile Cooperates with siRNA for Enhanced Cancer Immunochemotherapy by Amplifying Pt-DNA Adducts and Reducing Phosphatidylserine Exposure

Wei,

Fan,

Yan

et al. 2023

J. Am. Chem. Soc.

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Patients treated with Pt-based anticancer drugs (Pt II ) often experience severe side effects and are susceptible to cancer recurrence due to the limited bioavailability of Pt II and tumor-induced immunosuppression. The exposure of phosphatidylserine on the cell's outer surface induced by Pt II results in profound immunosuppression through the binding of phosphatidylserine to its receptors on immune cells. Here, we report a novel approach for enhanced cancer chemoimmunotherapy, where a novel nuclear-targeting lipid Pt IV prodrug amphiphile was used to deliver a small interfering RNA (siXkr8) to simultaneously amplify Pt-DNA adducts and reduce the level of exposure of phosphatidylserine. This drug delivery vehicle is engineered by integrating the Pt IV prodrug with self-assembly performance and siXkr8 into a lipid nanoparticle, which shows tumor accumulation, cancer cell nucleus targeting, and activatable in a reduced microenvironment. It is demonstrated that nucleartargeting lipid Pt IV prodrug increases the DNA cross-linking, resulting in increased Pt-DNA adduct formation. The synergistic effects of the Pt IV prodrug and siXkr8 contribute to the improvement of the tumor immune microenvironment. Consequently, the increased Pt-DNA adducts and immunogenicity effectively inhibit primary tumor growth and prevent tumor recurrence. These results underscore the potential of utilizing the nuclear-targeting lipid Pt IV prodrug amphiphile to enhance Pt-DNA adduct formation and employing siXkr8 to alleviate immunosuppression during chemotherapy.

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Combination of chemistry and material science to overcome health problems

Cited by 15 publications

References 12 publications

Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2‐Mediated Unfolded Protein Reaction Activation

Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2‐Mediated Unfolded Protein Reaction Activation

Design of biodegradable polyurethanes and post-modification with long alkyl chains via inhibiting biofilm formation and killing drug-resistant bacteria for the treatment of wound bacterial infection

Nuclear-Targeting Lipid Pt^IV Prodrug Amphiphile Cooperates with siRNA for Enhanced Cancer Immunochemotherapy by Amplifying Pt-DNA Adducts and Reducing Phosphatidylserine Exposure

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Combination of chemistry and material science to overcome health problems

Cited by 15 publications

References 12 publications

Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2‐Mediated Unfolded Protein Reaction Activation

Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2‐Mediated Unfolded Protein Reaction Activation

Design of biodegradable polyurethanes and post-modification with long alkyl chains via inhibiting biofilm formation and killing drug-resistant bacteria for the treatment of wound bacterial infection

Nuclear-Targeting Lipid PtIV Prodrug Amphiphile Cooperates with siRNA for Enhanced Cancer Immunochemotherapy by Amplifying Pt-DNA Adducts and Reducing Phosphatidylserine Exposure

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Product

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Nuclear-Targeting Lipid Pt^IV Prodrug Amphiphile Cooperates with siRNA for Enhanced Cancer Immunochemotherapy by Amplifying Pt-DNA Adducts and Reducing Phosphatidylserine Exposure