Design of biodegradable polyurethanes and post-modification with long alkyl chains <i>via</i> inhibiting biofilm formation and killing drug-resistant bacteria for the treatment of wound bacterial infection

Gu, Wenhao; Ren, Zhe; Han, Jie; Zhang, Xue; Zhu, Binghua; Yan, Zheng; Xiao, Haihua; Wei, Qiuhua

doi:10.1039/d3bm01448g

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Due to bacterial cell respiratory chain processes, the reduction in MTT to purple formazan occurs, which can be measured by spectrophotometry. The intensity of the change is proportional to live bacteria cells; thus, this is called the viability assay, allowing the measurement of quantities of live cells in biofilm [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light

Zmejkoski,

Zdravković,

Budimir Filimonović

et al. 2024

JFB

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In this study, nanochitosan dots (ChiDs) were synthesized using gamma rays and encapsulated in bacterial cellulose (BC) polymer matrix for antibiofilm potential in photodynamic therapy. The composites were analyzed for structural changes using SEM, AFM, FTIR, XRD, EPR, and porosity measurements. Additionally, ChiD release was assessed. The results showed that the chemical composition remained unaltered, but ChiD agglomerates embedded in BC changed shape (1.5–2.5 µm). Bacterial cellulose fibers became deformed and interconnected, with increased surface roughness and porosity and decreased crystallinity. No singlet oxygen formation was observed, and the total amount of released ChiD was up to 16.10%. Antibiofilm activity was higher under green light, with reductions ranging from 48 to 57% under blue light and 78 to 85% under green light. Methicillin-resistant Staphylococcus aureus was the most sensitive strain. The new photoactive composite hydrogels show promising potential for combating biofilm-related infections.

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Section: Introductionmentioning

confidence: 99%

Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light

Zmejkoski,

Zdravković,

Budimir Filimonović

et al. 2024

JFB

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Cationic 4-Vinylpyridine Copolymer Nanospheres with Dual Active Centers for Antibacterial Coatings

Ma,

Sun,

et al. 2024

ACS Appl. Nano Mater.

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Design of biodegradable polyurethanes and post-modification with long alkyl chains via inhibiting biofilm formation and killing drug-resistant bacteria for the treatment of wound bacterial infection

Abstract: Biodegradable polyurethanes with tertiary amines and quaternary ammonium salts exhibit potent antibacterial activity against bacteria.

Cited by 2 publications

References 33 publications

Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light

Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light

Cationic 4-Vinylpyridine Copolymer Nanospheres with Dual Active Centers for Antibacterial Coatings

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