Combination Antiretroviral Therapy Including a Protease Inhibitor Eliminated the Transfusion Requirements of HIV-Infected Individuals With Anemia of Chronic Disease

Mylonakis, Eleftherios; Dickinson, Brian P.; Feller, Alexander; Sweeney, Joseph D.; Schiffman, Fred J.; Rich, Jody; Flanigan, Timothy P.

doi:10.1097/00042560-199811010-00014

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…A longitudinal natural history study demonstrated that haemoglobin levels increased with ART, and haemoglobin decreased further in the control group not receiving ART during the same period (34). An early report suggested that anti-retroviral combination therapy reduces the transfusion requirements for some HIV-infected patients with anaemia of chronic disease (38). However, a more comprehensive study of patients with advanced HIV disease does not support an independent beneficial effect of ART on anaemia after adjustment for calendar period and time on study (39).…”

Section: Discussionmentioning

confidence: 99%

Increase of haemoglobin levels by anti‐retroviral therapy is associated with a decrease in immune activation

Sarcletti¹,

Quirchmair²,

Weiss³

et al. 2003

European J of Haematology

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Section: Discussionmentioning

confidence: 99%

Increase of haemoglobin levels by anti‐retroviral therapy is associated with a decrease in immune activation

Sarcletti¹,

Quirchmair²,

Weiss³

et al. 2003

European J of Haematology

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“…198 Among 11 patients who previously required blood transfusions because of the anemia of chronic disease, HAART improved hemoglobin concentrations and eliminated the requirements for blood transfusions. 199 …”

Section: Antiretroviral Medicationsmentioning

confidence: 99%

Pathogenesis of Anemia during Human Immunodeficiency Virus Infection

Semba

Gray

2001

Journal of Investigative Medicine

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“…6 An early report suggested that HAART reduced the transfusion requirements for some HIV-infected patients with anemia of chronic disease. 11 A study among HIV-infected injection drug users in Baltimore, Maryland, showed that the prevalence of anemia after 1 year was reduced among adults receiving HAART compared to those who did not receive any antiretroviral therapy. 13 During HIV infection, women appear to be at higher risk of anemia than men.…”

Section: Introductionmentioning

confidence: 99%

Highly Active Antiretroviral Therapy Associated with Improved Anemia Among HIV-Infected Women

Semba

Shah

Klein

et al. 2001

AIDS Patient Care and STDs

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Anemia is common during human immunodeficiency virus (HIV) infection and is associated with increased mortality. We conducted a study to examine the impact of highly active antiretroviral therapy (HAART) on anemia in a multicenter cohort of HIV-positive women, the Human Immunodeficiency Virus Epidemiology Research (HER) Study. Among women receiving HAART (n = 188), non-HAART monotherapy or combination antiretroviral therapy (ART) (n = 111), or who had no reported treatment (n = 62), the prevalence of anemia (hemoglobin, <120 g/L) at baseline was 38.3, 36.9, and 43.6%, respectively (p = 0.58) and at 1-year follow-up was 26.1%, 36.9%, 45.2%, respectively (p = 0.01); mean hemoglobin at baseline was 125 +/- 16, 122 +/- 16, and 122 +/- 18 g/L, respectively (p = 0.29) and at 1-year follow-up was 128 +/- 14, 123 +/- 16, and 119 +/- 20 g/L, respectively (p < 0.0001). Adjusted linear regression models showed that HAART was associated with an increase of hemoglobin of 0.20 g/L per month (p = 0.007). After 1 year of treatment, HAART was associated with a 32% reduction in anemia among HIV-infected women (p = 0.01), whereas there was no significant change in the prevalence of anemia among those on non-HAART ART or those who had no reported treatment. HAART is associated with a large reduction in anemia among HIV-infected women.

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Combination Antiretroviral Therapy Including a Protease Inhibitor Eliminated the Transfusion Requirements of HIV-Infected Individuals With Anemia of Chronic Disease

Cited by 7 publications

References 6 publications

Increase of haemoglobin levels by anti‐retroviral therapy is associated with a decrease in immune activation

Increase of haemoglobin levels by anti‐retroviral therapy is associated with a decrease in immune activation

Pathogenesis of Anemia during Human Immunodeficiency Virus Infection

Highly Active Antiretroviral Therapy Associated with Improved Anemia Among HIV-Infected Women

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