Comamonas kerstersii Bacteremia of Unknown Origin

Rong, Kassie; Delport, Johan; AlMutawa, Fatimah

doi:10.1155/2022/1129832

Cited by 6 publications

(9 citation statements)

References 12 publications

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“…To date, only 2 cases of extra-abdominal infections caused by C kerstersii have been reported: urinary tract infection [ 6 ] and bacteremia. [ 11 ] We present the second reported case of urinary tract infection (Case 2) and the first case of lung infection (Case 1) caused by C kerstersii. These cases demonstrate the importance of identifying potential extra-abdominal pathogenicity of C kerstersii .…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 ] Matrix-assisted laser desorption ionization time-of-flight mass spectrometry has emerged as the preferred choice because of its quick turnaround, accuracy, and ease of use in distinguishing closely related species. [ 11 , 12 ] For Comamonas species, 16S rRNA gene sequencing, the gold standard bacterial identification method, could not classify them as mentioned above. Although genomic sequencing analysis has shown promise for bacterial identification, it is not yet a routine laboratory method for bacterial identification.…”

Section: Discussionmentioning

confidence: 99%

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Extra-abdominal infections caused by Comamonas kerstersii: Case report

Wang,

Chen

et al. 2024

Medicine

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Rationale: Comamonas kerstersii mainly causes intra-abdominal infections with favorable outcomes due to high antibiotic susceptibility. We report the first case of pneumonia caused by C Kerstersii, which promoted patient death, and a second urinary tract infection by C Kerstersii with extensive drug resistance. Patient concerns: A 46-year-old male (Case 1) with craniocerebral injury underwent emergency decompressive craniectomy, but his condition deteriorated further and presented with discontinuous fever, small moist rales on both lungs, and respiratory failure. Retrospective average nucleotide identity (ANI) analysis of the genomic sequence of the sputum isolate identified it as C Kerstersii 12322-1, antimicrobial susceptibility testing (AST) revealed that it was sensitive to 18 of 21 tested antibiotics. An 82-year-old male (Case 2) with hypertrophic prostate experienced gradual obstruction during urination, and a urine test revealed WBC ++. Retrospective ANI analysis of the urine isolate identified it as C Kerstersii 121606, which was resistant to 18 of 21 tested antibiotics. Diagnoses: Case 1 was diagnosed empirically as pneumonia caused by C Kerstersii strain 12322-1 secondary to craniocerebral injury and confirmed by retrospective ANI analysis; case 2 was diagnosed empirically as urinary infection secondary to prostate hyperplasia caused by C Kerstersii strain 121606 confirmed by the retrospective ANI analysis. Interventions: Case 1 was administered cefoxitin, cefodizime, imipenem-cilastatin sodium, and underwent comprehensive salvage management. Case 2 was administered doxycycline alone. Outcomes: Case 1 died partially because of untimely identification of the responsible bacteria-12322-1. Case 2 was cured even 121606 exhibited an extensive drug resistance feature. Lessons: Except for intra-abdominal infections with good prognosis, we verified that C Kerstersii could also cause extra-abdominal infections, such as the first pneumonia case and urinary infection. It could promote patient death; actual infections were underestimated due to identification difficulties, posing a health threat due to the presence of extensive drug resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extra-abdominal infections caused by Comamonas kerstersii: Case report

Wang,

Chen

et al. 2024

Medicine

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“…One case reported a poly-microbial bacteremia by C. kerstersii and Bacteroides fragilis in a patient with diverticulosis who had ingested river water before his onset of symptoms, indicating that environmental material may serve as source of such pathogen ( 23 ). Rong et al reported a case of bacteremia caused by C. kerstersii without identifiable origin of the organism ( 24 ). Although the patient had no abdominal symptoms or past infections that can be linked to this occurrence, the type 2 diabetes with diabetic neuropathy hinted his weakened immunity, which may contribute to the infection of C. kerstersii .…”

Section: Discussionmentioning

confidence: 99%

Bacteremia caused by Comamonas kerstersii in a patient with acute perforated appendicitis and localized peritonitis: case report and literature review

Zhang,

Li,

Zhan

et al. 2023

Front. Med.

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Comamonas kerstersii (C. kerstersii) is a Gram-negative bacterium that was initially thought to be non-pathogenic to humans and is abundant in the environment. In recent years, with the availability of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) that enable fast and accurate bacterial identification, there have been increasing number of reports of human infections caused by C. kerstersii, indicating that this organism has emerged as human pathogen. In fact, most clinical isolates of C. kerstersii are recovered from peritoneal liquid, and bacteremia has been infrequently reported. Here, we report a case of bacteremia caused by C. kerstersii in a 28-year-old male patient with acute perforated appendicitis and localized peritonitis and present a comprehensive review of C. kerstersii infections in pathogenic diagnosis and clinical treatment as well as prognosis, thus providing a better understanding of C. kerstersii-related infections.

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“…The newest case report involving C. kerstersii infection is from March 2022. The prescribed case is unusual since the patient neither had predisposing conditions for his bacteremia, nor abdominal symptoms, except for recent constipation[ 14 ]. Although some strains are resistant to cephalosporins, the reports that have been discussed indicate excellent treatability with antibiotics and an optimistic prognosis following infection[ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Maternal peripartum bacteremia caused by intrauterine infection with Comamonas kerstersii: A case report

Qu¹,

Zhao²,

Zhu³

et al. 2022

WJCC

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BACKGROUND Comamonas kerstersii ( C. kerstersii ) infections have considered as non-pathogenic to humans, however due to new techniques such as matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS), more cases have been identified. CASE SUMMARY This is the first report of a maternal patient with a C. kerstersii bacteremia following caesarean section. Due to the severity of the patient’s condition; high fever and rapidly progressing organ damage, the patient was transferred to the intensive care unit. C. kerstersii was detected by metagenomic next-generation sequencing testing. Based on the drug sensitivity test, appropriate antibiotic treatment was given and the patient recovered fully. CONCLUSION This case report confirms that the detection via MALDI-TOF-MS and metagenomic next-generation sequencing testing provides a reliable basis for the diagnosis of this rare bacterial infection.

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Comamonas kerstersii Bacteremia of Unknown Origin

Cited by 6 publications

References 12 publications

Extra-abdominal infections caused by Comamonas kerstersii: Case report

Extra-abdominal infections caused by Comamonas kerstersii: Case report

Bacteremia caused by Comamonas kerstersii in a patient with acute perforated appendicitis and localized peritonitis: case report and literature review

Maternal peripartum bacteremia caused by intrauterine infection with Comamonas kerstersii: A case report

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