Colostrum from primiparous Holstein cows shows higher antioxidant activity than colostrum of multiparous ones

Abstract

Antioxidant components of colostrum prevent oxidative cell damage caused by free radicals that could harm the calf's development. The relationship of antioxidant potential of colostrum with parity is not well defined and could enlighten the importance of these components for the neonate and for the protection of the intestinal epithelium. The purpose of this work was to determine the antioxidant potential of colostrum from primiparous and multiparous Holstein cows in a commercial dairy farm. Samples from the first milk secretion from primiparous (first lactation, n = 8) and multiparous (second and third lactations, n = 8) Holstein cows were collected after birth of calves for determination of immune and antioxidant factors. The cows sampled in this study were vaccinated during pregnancy in order to improve colostrum quality. Colostrum from primiparous cows showed higher values of ceruloplasmin activity, oxygen radical absorbance capacity (ORAC) and transferrin saturation index (TSI) than colostrum from multiparous cows (P < 0.05). The total iron binding capacity (TIBC) and transferrin concentration in the colostrum of primiparous cows showed a non-significant numerical decrease (P = 0.06) in relation to the value in the colostrum of multiparous cows. Concentration of proteins, immunoglobulin G, and activity of lactoperoxidase, lysozyme, glutathione peroxidase and catalase, in turn, did not differ (P > 0.05). Metabolic differences between primiparous and multiparous cows may have affected the antioxidative status of colostrum, since ORAC values were twice higher in first lactation cows. Lower values of transferrin and TIBC and higher TSI in colostrum from primiparous cows suggests a relationship between lower iron stock and higher antioxidant activity. Thus, this work indicates an important role of the antioxidant potential of colostrum for neonates from first-lactation cows. Additionally, the iron stock may be directly related to the higher antioxidant potential of the colostrum from primiparous cows, and further investigations are required.

Expression Patterns of Major Genes in Fatty Acid Synthesis, Inflammation and Oxidative Stress Related Pathways and Quality Parameters During the Transition From Colostrum to Milk in Dairy Goats

“…With the beginning of lactation, antioxidant and immunological mechanisms have showed abnormal regulation in mammary gland. Antioxidant status of colostrum is important for maternal physiology and offspring health 35 . COX-2 and NRF2 are the most related genes with the oxidative status of tissues and biological liquids and have tended to be upregulation in response to immunological activity 36,37 .…”

A Neuroprotective Bovine Colostrum Attenuates Apoptosis in Dexamethasone-Treated MC3T3-E1 Osteoblastic Cells

“…Despite this constraint, the vast majority of colostrum constituents have been tested singly on numerous cell-based systems and, particularly, there is ample knowledge of their antioxidant, anti-apoptotic, and cell proliferation/differentiation-promoting activities. Antioxidant components of colostrum, such as the iron-binding protein lactoferrin, the colostral component similar to ascorbate [ 16 ], glutathione peroxidase, catalase [ 17 ], and proline-rich polypeptide (PRP) complex known as colostrinin [ 18 , 19 ], among others, have been shown to prevent oxidative cell damage both in osteoblast and neurons. Furthermore, in vitro modulation of cell proliferation/differentiation and apoptosis has been described by colostrum constituents such as ribonucleosides [ 20 ], colostrinin [ 21 ], insulin-like growth factor 1 (IGF-1) [ 22 , 23 ], growth hormone (GH), platelet-derived growth factor (PDGF) [ 24 ], insulin [ 25 ], leptin [ 26 ], unsaturated fatty acids and calcium [ 27 ] and lactoferrin [ 28 ].…”

“…Interestingly, in our lab screen for the search of neuroprotective compounds and products, bovine colostrum displayed some degree of neuroprotective activity when tested in a glucocorticoid (GC)-induced neuroblastoma cell model of damage. Based on this finding and the remarkable composition of bovine colostrum and the activities of its components reported in the literature [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ], we proceeded our study focusing on the effects of this particular colostrum on dexamethasone (DEX)-treated MC3T3-E1 osteoblastic cells for assessing a possible anti-apoptotic activity. DEX has been chosen, among the various GCs, on the basis that phenotypic changes derived from cell exposure to this GC are more consistent and prominent [ 32 , 33 ].…”

Presencia Del Virus De La Leucosis Bovina en Muestras De Calostro Y Su Potencial Para Infectar Terneros

“…Infections by pathogens such as bacteria or viruses constantly affect dairy systems, and therefore, the proper development of the immune system is essential. In this sense, colostrum is a source of nutrients and antimicrobial factors such as lysozymes or lactoferrin, which protect the calf from infections during the first week of life (Furman-Fratczak et al, 2011;Moretti et al, 2020). However, antibodies or immunoglobulins are responsible for generating passive immunity during the first days of calves (Hurley et al, 2011;Agianniotaki et al, 2018).…”