Colostral transfer of gamma glutamyl transferase in lambs

Pauli, J. V.

doi:10.1080/00480169.1983.35004

Cited by 20 publications

(21 citation statements)

References 4 publications

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“…To the best of our knowledge, there are no other studies in which STPC is determined prior to colostrum intake. The mean STPC on different days of the first week of life (70-73 g/L) in our study was similar to figures reported by Brujeni et al [16] , but comparatively higher than that reported by Loste et al [28] , Massimini et al [5] , Pauli [30] and lower than that of Bekele et al [2] and Oztabak and Ozpinar [29] . In our study, the mean STPC on day 14 (63 g/L) was lower than that reported by Brujeni et al [16] , Oztabak and Ozpinar [29] , but comparatively higher than that of Loste et al [28] .…”

Section: Gökçe Ataki̇şi̇supporting

confidence: 89%

“…Our study found that STPC (40±6 g/L) prior to colostrum intake (hour 0), similar to levels expected in severe passive immune deficiency, were lower than the levels (58-69 g/L) reported by Oztabak and Ozpinar [29] , but similar to data from Pauli [30] , 40.7 g/L. To the best of our knowledge, there are no other studies in which STPC is determined prior to colostrum intake.…”

Section: Gökçe Ataki̇şi̇supporting

confidence: 81%

See 1 more Smart Citation

Kuzularda Serum ve Kolostral IgG (Pasif İmmünite) Konsantrasyonlarının Total Protein ve Sağlık İle İlişkisi

Atakisi¹

2018

Kafkas Univ Vet Fak Derg

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This study was designed to determine relationship between sheep serum before lambing, colostrum and 1-day-old lamb serum total protein (TP) and immunoglobulin-G (IgG) concentration and their effect on neonatal diseases and also the linear relationship between serum TP and IgG concentration (STPC and SIgGC, respectively) in different days of the neonatal period thereby determining the feasibility of TP concentration in the prediction of colostrum quality and passive immunity and to define a cutoff point for STPC and SIgGCat 24 h after birth (STPC-24 and SIgGC-24, respectively) associated with increased risk of illness or death in lambs. For this purpose, blood was obtained from the lambs and ewes at day 1 (n=325), at day 0 (before colostrum intake) and on different days in neonatal periods (n=50) and blood (10-15 days before lambing) and colostrum were obtained from the respective ewes related to the lambs. Mean serum TP and IgG concentrations on days 1, 2, 4, 7, 14 and 28 were significantly higher than values on day 0 (before colostrum intake) from the lambs remained healthy in neonatal period. The STPC-24 was significantly lower in diseased and dead lambs when compared to healthy lambs in the neonatal period (P<0.001 and P<0.001 respectively). The STPC-24 in lambs that died or became ill was 62% to 67% in SIgGC-24, respectively. Mean colostral TPC was significantly (P<0.05) higher in dams (n=254) of healthy lambs when compared to those of sick lambs in neonatal period. There was a significant correlation between the dams' STPC and both the SIgGC in dams and SIgGC-24 in their lambs (R=0.454, R=0.342, respectively). The study revealed that STPC-24 >55 g/L and SIgGC-24>600 mg/ dL is probably consistent with adequate level of passive transfer. It was also noted that in addition to determining colostrum quality, STPC plays an essential role in the prediction and prevention of neonatal diseases in lambs. In conclusion, immediate and inexpensive determination of TP concentrations is beneficial in making timely management and treatment decisions related to failure of passive transfer (FPT).

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Section: Gökçe Ataki̇şi̇supporting

confidence: 89%

Section: Gökçe Ataki̇şi̇supporting

confidence: 81%

Kuzularda Serum ve Kolostral IgG (Pasif İmmünite) Konsantrasyonlarının Total Protein ve Sağlık İle İlişkisi

Atakisi¹

2018

Kafkas Univ Vet Fak Derg

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“…The determination of passive transfer status may assist differentiation of lambs suffering from failure of passive transfer with overwhelming septicaemia from lambs suffering from hypoglycaemia or hypothermia. This information is valuable when selecting treatment regimens and predicting outcomes (Halliday, 1978;Pauli, 1983;.In this study, serum c-GT activity as well as IgG concentration significantly increased on the 1st and 3rd days of the experiment (Table 1) with significant correlation (Table 2). Colostrum/milk c-GT activity significantly increased during the experiment (Table 1) and significant correlation was found between colostrum/milk c-GT activity and IgG concentration on the (0), 1st and 3rd days of the experiment.…”

Section: Discussionmentioning

confidence: 50%

Blood and Colostrum/Milk Serum γ‐Glutamyltransferase Activity as a Predictor of Passive Transfer Status in Lambs

Maden¹,

Altunok²,

Bi̇rdane³

et al. 2003

Journal of Veterinary Medicine, Series B

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The importance of blood and colostrum/milk serum gamma-glutamyl transferase (gamma-GT) enzyme activity was evaluated to assess passive transfer status in healthy lambs. Thirty Akkaraman sheep (3-6 years old) were used which had normal pregnancy period and the same conditions, and the age of the lambs ranged between 0 and 15 days. Blood and colostrum/milk samples were collected from sheep and lambs after birth, before suckling (0) and after on 1st, 3rd, 7th and 15th days. Serum immunoglobulin G (IgG) concentration was determined by the use of Single Radial Immunodiffusion method. Serum gamma-GT activity was measured, using a commercially available kit in blood and colostrum/milk samples. Correlations were carried out between immunoglobulin and gamma-GT levels. Regression models (simple and multiple) were calculated with significant data. Linear correlation was determined between colostrum/milk gamma-GT activity and IgG concentrations and between serum gamma-GT activity and IgG concentrations in lambs on the 0 day. (r: 0.607, P: 0.001), 1st (r: 0.768, P: 0.001) and the 3rd (r: 0.603, P: 0.001) days and on the 1st (r: 0.637, P: 0.001) and 3rd (r: 0.478, P: 0.012) days in the experiment, respectively. Multivariate regression models were developed to estimate sample IgG concentration. Serum and colostrum/milk IgG concentration could be predicted using the formula: lamb serum IgG = 825 + 0.688 (lamb gamma-GT) + 52 (days); colostrum/milk IgG = 832 + 0.505 (colostrum/milk gamma-GT) - 167 (days). The regression models were moderately accurate in predicting serum IgG concentration (R2 = 0.51) and colostrum/milk IgG concentration (R2 = 0.55). Test sensitivity and positive predictive values for serum gamma-GT enzyme activity were found to be 96 and 100% and for colostrum/milk gamma-GT enzyme activity were found to be 100 and 68% to prediction IgG concentration. Serum and colostrum/milk gamma-GT activity can be used to assess passive transfer status of lambs. Along with this, regression models used to calculate serum and colostrum/milk gamma-GT activities found to be useful to estimate sample IgG concentration. The use of serum and colostrum/milk gamma-GT enzyme activity was found useful especially after birth on the 0, 1st and 3rd days.

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“…Compared with γ‐GT and AP, consistent associations of AST activities with the time of first colostrum intake were, however, not obvious. Pauli (1983) reported a post‐suckling increase of plasma AST activity in lambs and suggested, that serum AST was derived from the intestinal brush border because of the low AST activity in colostrum. In accordance, Frerking et al.…”

Section: Discussionmentioning

confidence: 99%

Activities of γ‐Glutamyltransferase, Alkaline Phosphatase and Aspartate‐Aminotransferase in Colostrum, Milk and Blood Plasma of Calves Fed First Colostrum at 0–2, 6–7, 12–13 and 24–25 h after Birth

Zanker

Hammon

Blum

2001

Journal of Veterinary Medicine Series A

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Enzyme activities of gamma-glutamyltransferase (gamma-GT), alkaline phosphatase (AP) and aspartate-aminotransferase (AST) were measured from birth to the age of 28 days in calves which were fed colostrum at 0-2, 6-7, 12-13, or 24-25 h after birth. Enzyme activities were also measured in colostrum (first to fifth milking) and in mature milk. Activities were highest in the first colostrum milking and decreased to the lowest activities in mature milk. Plasma gamma-GT activity transiently increased after first colostrum intake and was greater in calves fed first colostrum within less than 6-7 h than in those fed first colostrum later than 12 h after birth. Activity of gamma-GT reflected the absorption of colostral gamma-GT, which decreased with time after birth. The AP activity transiently increased after colostrum intake and was higher in calves fed colostrum within the first 12 h of life than in those fed later after birth. The transient rise of plasma AP activity also indicated absorption of colostral AP, although endogenous sources of AP could not be excluded. The activity of AST also transiently increased after colostrum intake but there was no association with time of first colostrum feeding, indicating that the rise of plasma AST activity was the consequence of enhanced endogenous production and was independent of colostrum intake. In conclusion, there are different causes leading to postnatal changes in enzyme activities.

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Colostral transfer of gamma glutamyl transferase in lambs

Cited by 20 publications

References 4 publications

Kuzularda Serum ve Kolostral IgG (Pasif İmmünite) Konsantrasyonlarının Total Protein ve Sağlık İle İlişkisi

Kuzularda Serum ve Kolostral IgG (Pasif İmmünite) Konsantrasyonlarının Total Protein ve Sağlık İle İlişkisi

Blood and Colostrum/Milk Serum γ‐Glutamyltransferase Activity as a Predictor of Passive Transfer Status in Lambs

Activities of γ‐Glutamyltransferase, Alkaline Phosphatase and Aspartate‐Aminotransferase in Colostrum, Milk and Blood Plasma of Calves Fed First Colostrum at 0–2, 6–7, 12–13 and 24–25 h after Birth

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