Colorimetric sensing strategy for heparin assay based on PDDA-induced aggregation of gold nanoparticles

Ma, Xiaoyi; Kou, Xinyue; Xu, Yuanyuan; Yang, Dawei

doi:10.1039/c8na00162f

Cited by 28 publications

(11 citation statements)

References 30 publications

(28 reference statements)

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“…The analyte-triggered aggregation for chemical and biological sensing applications is performed based on the affinity of analytes such as the electrostatic or hydrogen-bonding interaction toward unmodified AuNPs. For example, Ma et al devised a simple assay for the sensitive and selective colorimetric detection of heparin [76]. In the absence of heparin, the poly(diallyldimethylammonium chloride) (PDDA) with positive charges can easily adsorb onto the citrate-capped AuNP surfaces by electrostatic attraction (Figure 7).…”

Section: Aggregation-based Colorimetric Assaysmentioning

confidence: 99%

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Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

et al. 2019

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Gold nanoparticles are popularly used in biological and chemical sensors and their applications owing to their fascinating chemical, optical, and catalytic properties. Particularly, the use of gold nanoparticles is widespread in colorimetric assays because of their simple, cost-effective fabrication, and ease of use. More importantly, the gold nanoparticle sensor response is a visual change in color, which allows easy interpretation of results. Therefore, many studies of gold nanoparticle-based colorimetric methods have been reported, and some review articles published over the past years. Most reviews focus exclusively on a single gold nanoparticle-based colorimetric technique for one analyte of interest. In this review, we focus on the current developments in different colorimetric assay designs for the sensing of various chemical and biological samples. We summarize and classify the sensing strategies and mechanism analyses of gold nanoparticle-based detection. Additionally, typical examples of recently developed gold nanoparticle-based colorimetric methods and their applications in the detection of various analytes are presented and discussed comprehensively.

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Section: Aggregation-based Colorimetric Assaysmentioning

confidence: 99%

“…However, when heparin is present, the PDDA molecules will interact with the heparin, which prevents the PDDA-induced aggregation of the AuNPs. Reproduced with permission from Reference [76]. Royal Society of Chemistry, 2019.…”

Section: Figurementioning

confidence: 99%

Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

et al. 2019

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“…[6][7][8]31,32] A ratio frequently used in this type of study is calculated as LSPR maximum absorptions of the non-aggregated versus aggregated nanoparticles, Abs Non-Agg /Abs Agg . [8,31,[33][34][35][36][37][38] For instance, these types of ratios were previously used for ≈14 and ≈35 nm spherical AuNPs as Abs 525nm /Abs 585nm and Abs 542nm / Abs 700nm , respectively. [31,33] Based on UV-vis spectra from the examples in Figure S8, Supporting Information, a higher ratio is expected for the Au nanoprobe hybridized with a fully complementary DNA compared to hybridization with a mismatched DNA, corresponding to differences in their aggregation profile.…”

Section: Non-cross-linking Detection Of An Snp Associated With Lactos...mentioning

confidence: 99%

Improved Gold Nanoprobes for Detection of Single Nucleotide Polymorphisms: The Influence of Size

Enea

Almeida

Dias

et al. 2022

Part & Part Syst Charact

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Gold nanoparticles (AuNPs) are widely used in biomedical diagnostics due to their unique plasmonic properties, with larger AuNPs showing higher extinction coefficients for the plasmon band and, consequently, more intense colors than the more commonly used spherical 20 nm AuNPs. Other factors can be important in the performance of different‐sized AuNPs, including surface area, colloidal stability, and curvature effects. Here, the properties of spherical 20 nm AuNPs and 35 nm AuNPs functionalized with a specific thiol‐modified oligonucleotide–Au nanoprobes are compared when used on a colorimetric assay for the detection of a single nucleotide polymorphism related to lactose intolerance in humans. Successful functionalization of AuNPs is assessed by UV–vis spectroscopy, agarose gel electrophoresis, dynamic and electrophoretic light scattering, and nanoparticle tracking analysis. Statistical differences between Au‐nanoprobe DNA target groups are calculated using analysis of variance and a post hoc Tukey's test. These results show that both 35 and 20 nm Au nanoprobes have similar detection limits using a 0.15 nmol dm−3 nanoprobe concentration compared to 2.5 nmol dm−3. Interestingly, the use of 35 nm Au nanoprobes allows a reduction of 80% and 48% in the amount of gold and oligonucleotide used in the assay, respectively.

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“…Colorimetric sensors produce colorimetric signal induced by a coloration reaction of catalyst, chromogenic substrates and H 2 O 2 , [49] which is reliable, easy operational and less time-consuming. [120] Biocatalytic MOF-based colorimetric sensors shows emerging application in biomarker detection. For example, to screen α-Glucosidase (GAA)…”

Section: Optical Sensorsmentioning

confidence: 99%

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

Liang

2020

Adv Funct Materials

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Biocatalytic metal-organic framework (MOF) composites, synthesized by interfacing MOFs with biocatalytic components, possess the unprecedented synergetic properties that is hard to achieve by the conventional strategies, represents one of the next-generation composite materials for diverse biotechnological applications. Until now , research on the applications of biocatalytic MOFs is still in its preliminary stage, with a wide variety of studies being focusing on the bioprotection role of MOFs. However, their diversity of building units, molecular-scale tunability, modular synthetic routes, and more detailed understanding of the heterogeneous MOF-biointerface could even lead to completely new applications and potentials beyond our current imagination. The most recent rapid advanced progress in biocatalytic MOFs present ground-breaking applications in smart and tunable biocatalysis, precision nanomedicine, vaccine and gene delivery, biosensing and nano-biohybrids. Herein, the general and advanced synthesis strategies for improving the materials properties of biocatalytic MOFs, from tuning biocatalytic activity to framework stability to synergistic properties with other materials, are summarized. Then, the latest state-of-the-art applications of the biocatalytic MOF systems and recent advanced developments that are shaping this emerging field are surveyed. Finally, to define promising research directions, a critical evaluation and future prospects for the potential applications of biocatalytic MOFs are provided.

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Colorimetric sensing strategy for heparin assay based on PDDA-induced aggregation of gold nanoparticles

Abstract: We have developed a highly sensitive colorimetric sensor for the detection of heparin based on its anti-aggregation effect of the PDDA–gold nanoparticle colloidal system.

Cited by 28 publications

References 30 publications

Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

Improved Gold Nanoprobes for Detection of Single Nucleotide Polymorphisms: The Influence of Size

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

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