Colorimetric logic gates for small molecules using split/integrated aptamers and unmodified gold nanoparticles

Xu, Xiaowen; Zhang, Jia; Yang, Fan; Yang, Xiurong

doi:10.1039/c1cc13459k

Cited by 70 publications

(51 citation statements)

References 55 publications

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“…For example, one AND gate nanoplatform designed for small molecule sensing used aptamer-modified gold nanoparticles to detect both adenosine and cocaine, inducing nanoparticle aggregation that resulted in a solution color change as the output [13]. Overall, DNA-based aggregation systems utilize the temperature stability and well-characterized hybridization behavior of nucleic acids to create precise logic gate-based nanodevices.…”

Section: System Assembly As Means Of Integrating Inputsmentioning

confidence: 99%

Biocomputing nanoplatforms as therapeutics and diagnostics

Evans

Thadani

Suh

2016

Journal of Controlled Release

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Biocomputing nanoplatforms are designed to detect and integrate single or multiple inputs under defined algorithms, such as Boolean logic gates, and generate functionally useful outputs, such as delivery of therapeutics or release of optically detectable signals. Using sensing modules composed of small molecules, polymers, nucleic acids, or proteins/peptides, nanoplatforms have been programmed to detect and process extrinsic stimuli, such as magnetic fields or light, or intrinsic stimuli, such as nucleic acids, enzymes, or pH. Stimulus detection can be transduced by the nanomaterial via three different mechanisms: system assembly, system disassembly, or system transformation. The increasingly sophisticated suite of biocomputing nanoplatforms may be invaluable for a multitude of applications, including medical diagnostics, biomedical imaging, environmental monitoring, and delivery of therapeutics to target cell populations.

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Section: System Assembly As Means Of Integrating Inputsmentioning

confidence: 99%

Biocomputing nanoplatforms as therapeutics and diagnostics

Evans

Thadani

Suh

2016

Journal of Controlled Release

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“…The change of SPR peak can be applied as output signals of molecular computing. Various AuNPs-based colorimetric logic gates have been reported by using metal ions and small molecules as inputs [18][19][20][21]. However, it is very difficult to develop a molecular demultiplexer by using the reported AuNP-based logic gate systems because they have only a single optical output (the UV/Vis absorbance of AuNPs).…”

Section: Introductionmentioning

confidence: 98%

Multifunctional gold nanoparticles as signal transducers for fabrication of 1:2 molecular demultiplexer

2015

Anal Bioanal Chem

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A label-free and enzyme-free demultiplexer system for the fabrication of 1:2 molecular demultiplexer with luminol functionalized gold nanoparticles (Lum-AuNPs) as signal transducers was developed for the first time. The Lum-AuNPs had both chemiluminescence (CL) activity and surface plasmon resonance property. It was found that organothiols (RSH) could easily induce the aggregation of AuNPs via strong Au-S covalent interactions in the absence of hydrogen peroxide (H2O2), generating a red shift in the absorption band of AuNPs. However, the presence of H2O2 would readily oxidize RSH to disulfide (RS-SR), and the aggregation of Lum-AuNPs did not occur due to lack of the sulfhydryl group. Meanwhile, H2O2 could react with Lum-AuNPs, producing a strong CL emission owing to the enhancement effect of RSH on AuNPs-luminol-H2O2 CL system. Thus, RSH, H2O2, absorbance ratio, and CL intensity served as the signal input, address input, and two different signal outputs of the 1:2 molecular demultiplexer, respectively.

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“…Depending on the number and the relationship of the inputs in the system, a wide range of logic functions which include YES, NOT, AND, OR, NOR, NAND, INH, and XOR could be obtained. 35 To date, colorimetric logic gates based on the aggregation or anti-aggregation of Au NPs are mostly formulated by two inputs due to the lack of highly specic interactions between multiple target species, 24,[36][37][38][39][40] which thereby hampers the construction of a logically interconnected sensing system with more than two inputs. Therefore, different types of molecular sensors based on logic gate operations have been developed for the sensing of various targets such as metal ions, 31,32 neurotransmitter release, 33 DNA and aptamer, 34 and iodide.…”

Section: Introductionmentioning

confidence: 99%

A coordination and ligand replacement based three-input colorimetric logic gate sensing platform for melamine, mercury ions, and cysteine

et al. 2015

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Discrimination of different species in various target scopes within a single sensing platform can provide many advantages such as simplicity, rapidness, and cost effectiveness. Here we design a threeinput colorimetric logic gate, based on the aggregation and antiaggregation of gold nanoparticles (Au NPs), for the sensing of melamine, cysteine, and Hg 2+ . The concept makes use of the advantages of the highly specific coordination and ligand replacement reactions between melamine, cysteine, Hg 2+ , and Au NPs. Different outputs are obtained with the combinational inputs in the logic gates, which can serve as a reference to discriminate different analytes within a single sensing platform. Furthermore, besides the intrinsic sensitivity and selectivity of Au NPs to melamine-like compounds, the "INH" gates of melamine/cysteine and melamine/Hg 2+ in this logic system can be employed for sensitive and selective detections of cysteine and Hg 2+ , respectively.

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Colorimetric logic gates for small molecules using split/integrated aptamers and unmodified gold nanoparticles

Abstract: Herein we report the "OR" and "AND" colorimetric logic gates for small molecules using split/integrated aptamers and unmodified gold nanoparticles, which generate visually observed outputs according to Boolean operations.

Cited by 70 publications

References 55 publications

Biocomputing nanoplatforms as therapeutics and diagnostics

Biocomputing nanoplatforms as therapeutics and diagnostics

Multifunctional gold nanoparticles as signal transducers for fabrication of 1:2 molecular demultiplexer

A coordination and ligand replacement based three-input colorimetric logic gate sensing platform for melamine, mercury ions, and cysteine

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