Colorimetric histology using plasmonically active microscope slides

Balaur, Eugeniu; Toole, Sandra O’; Spurling, Alex; Mann, G. Bruce; Yeo, Belinda; Harvey, Kate; Sadatnajafi, Catherine; Hanssen, Eric; Orian, Jacqueline M.; Nugent, Keith A.; Parker, Belinda S.; Abbey, Brian

doi:10.1038/s41586-021-03835-2

Cited by 47 publications

(46 citation statements)

References 50 publications

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“…In another example, Balaur et al. [ 39 ] developed a plasmonic microscope slide that allows colorimetric histology of tissues without the use of staining by transducing minute changes in the dielectric constant of various tissue types into visibly detectable color changes ( Fig. 4 D).…”

Section: Signal Read-out Methodsmentioning

confidence: 99%

Plasmonic nanosensors for point-of-care biomarker detection

Jin

Molinski

et al. 2022

Materials Today Bio

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Section: Signal Read-out Methodsmentioning

confidence: 99%

Plasmonic nanosensors for point-of-care biomarker detection

Jin

Molinski

et al. 2022

Materials Today Bio

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“…Two of the most common applications reported for devices exhibiting EOT phenomena are colour filtering and chemical sensing 4 – 7 . More recently, these types of devices have also been exploited for enhanced imaging 8 , 9 and materials characterisation 10 .…”

Section: Introductionmentioning

confidence: 99%

Optical barcoding using polarisation sensitive plasmonic biosensors for the detection of self-assembled monolayers

Balaur

Sadatnajafi

Abbey

2022

Sci Rep

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Periodic subwavelength apertures have the ability to passively detect variations in the dielectric properties of the local sample environment through modification of the plasmon resonances associated with these structures. The resulting resonance peak can effectively provide a ‘fingerprint’ indicative of the dielectric properties of the medium within the near-surface region. Here we report on the use of bimodal silver-based plasmonic colour filters for molecular sensing. Firstly, by exploring the optical output of these devices as a function of the incident polarisation for a range of different analytes of known refractive index, we were able to both maximise and quantify their sensitivity. We then apply this concept to the real-time monitoring of the formation of self-assembled monolayers based on detection of the optical output using a spectrometer. This highlights the potential for bimodal plasmonic devices to be able to dynamically monitor variations in the local environment down to the level of single molecules without the need for specific functionalisation or labelling. Advantages of using this technique include the ability for these devices to be miniaturised and to dynamically tailor their optical output permitting the analysis of very small sample volumes and maximise their dynamic range for a specific analyte.

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“…For instance, plasmonic metasurfaces in the mid-infrared (mid-IR) can monitor changes in trace drugs inside the body by extracting generic molecular vibrational fingerprints, truly enabling wearable and noninvasive detection, which is challenging with traditional surface-enhanced Raman scattering spectroscopy methods [17]. Another recent work has used plasmonic metasurfaces as nanomicroscope slides for cellular imaging of breast cancer tissue and combined with colorimetric histology techniques to achieve naked eye differentiation between cancerous and normal tissue [18]. The combination of metasurface detection elements with laboratory and even human structures is transformative in bringing metasurfacebased spectral detection devices to the market.…”

Section: Introductionmentioning

confidence: 99%

Resonant Metasurfaces for Spectroscopic Detection: Physics and Biomedical Applications

Liang

Lai

Lou

et al. 2022

Adv Devices Instrum

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Metasurfaces are ultrathin metamaterials consisting of subwavelength scatterers (e.g., meta-atoms) arranged in a specific sequence that generates low radiation losses and fantastic optical resonances. According to the electromagnetic response properties, metasurfaces can be divided into two categories: metallic nanostructures based on the response of plasmonic excitations (e.g., noble metals and graphene) and all-dielectric nanostructures based on near-field scattering (e.g., Mie scattering). Metasurfaces supporting various optical modes possess optical localization and electromagnetic field enhancement capabilities on the subwavelength scale, making them a promising platform for label-free detection in biomedical sensing. Metasurface-based optical sensors offer several outstanding advantages over conventional spectroscopic detection solutions, such as planar structures, low loss, miniaturization, and integration. Recently, novel sensing and even imaging tools based on metasurfaces have widely loomed and been proposed. Given recent advances in the field of metasurface spectroscopic detection, this review briefly summarizes the main resonance mechanisms of metasurfaces and the notable achievements, including refractive index sensing, surface-enhanced Raman scattering, surface-enhanced infrared absorption, and chiral sensing in the ultraviolet to terahertz wavelengths. Ultimately, we draw a summary of the current challenges of metasurface spectroscopic detection and look forward to future directions for improving these techniques. As the subject is broad and growing, our review will not be comprehensive. Nevertheless, we will endeavor to describe the main research in this area and assess some of the relevant literature.

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Colorimetric histology using plasmonically active microscope slides

Cited by 47 publications

References 50 publications

Plasmonic nanosensors for point-of-care biomarker detection

Plasmonic nanosensors for point-of-care biomarker detection

Optical barcoding using polarisation sensitive plasmonic biosensors for the detection of self-assembled monolayers

Resonant Metasurfaces for Spectroscopic Detection: Physics and Biomedical Applications

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