Colorimetric determination of p-aminophenol in the presence of paracetamol with 3-cyano-N-methoxypyridinium perchlorate

Korany, Mohamed A.; Heber, Dieter; Schnekenburger, J.

doi:10.1016/0039-9140(82)80121-5

Cited by 19 publications

(5 citation statements)

References 6 publications

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“…Showing the best prediction power among the three methods (Table 2 ), the proposed GA–ANN models were used to determine CAF, COD and PAR in Solpadeine® tablets and results are shown in Table 6 . Statistics were used to compare the results obtained from application of the models on analysis of the compounds in pure powder with those produced by using the pharmacopeial methods 1 , 3 for the analysis of COD, CAF and PAR and the reported method 51 for the analysis of PAP in pure powder. As shown in Table 7 , no significant difference was found, which confirm the predictive ability of GA–ANN models.…”

Section: Resultsmentioning

confidence: 99%

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Advanced chemometric methods for simultaneous quantitation of caffeine, codeine, paracetamol, and p-aminophenol in their quaternary mixture

Kelani,

Fekry,

Fayez

et al. 2024

Sci Rep

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Two different multivariate techniques have been applied for the quantitative analysis of caffeine, codeine, paracetamol and p-aminophenol (PAP) in quaternary mixture, namely, Partial Least Squares (PLS-1) and Artificial Neural Networks (ANN). For suitable analysis, a calibration set of 25 mixtures with various ratios of the drugs and PAP impurity were established using a 4-factor 5-level experimental design. The most meaningful wavelengths for the chemometric models were chosen using Genetic Algorithm (GA) as a variable selection technique. By using an independent validation set, the validity of the proposed methods was evaluated. A comparative study was established between the three multivariate models (PLS-1, GA–PLS and GA–ANN). The comparison between the various models revealed that the GA–ANN model was superior at resolving the highly overlapped spectra of this quaternary combination. The drugs were successfully quantified in their pharmaceutical dosage form utilizing the GA–ANN models.

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Section: Resultsmentioning

confidence: 99%

“…PAP was supplied from Adwic, Egypt. Its purity was examined and found to be 99.45% according to reported method 51 . Solpadeine® tablets were purchased from local market and labelled to contain 500, 30 and 8 mg of PAR, CAF and COD, respectively.…”

Section: Methodsmentioning

confidence: 99%

Advanced chemometric methods for simultaneous quantitation of caffeine, codeine, paracetamol, and p-aminophenol in their quaternary mixture

Kelani,

Fekry,

Fayez

et al. 2024

Sci Rep

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“…While spectrophotometric detection with chromatographic separation has been frequently used for the quantification of PAP in paracetamol, only a few colorimetric methods are available as stand-alone procedures in the literature. These include those based on the oxidation of PAP with 3-cyano-Nmethoxypyridinium perchlorate (Korany et al, 1982) and either of Ce 4þ or Fe 3þ (Mohamed, AbdAllah, & Shammat, 1997) which were determined at 10-60 and 1-10 mg/mL, respectively. Our method, however, offers a number of advantages: the improved sensitivity and lower Beer's concentration range permit the micro analysis of PAP at levels not possible with these two methods as well as better recoveries.…”

Section: Validation Studiesmentioning

confidence: 99%

“…Different analytical methods for the detection and quantification of PAP in paracetamol formulations are described in the literature. These methods range from spectroscopic techniques including second derivative ultraviolet spectroscopy (Yesilada, Erdogan, & Ertan, 1991), colorimetry (Korany, Heber, & Schnekenburger, 1982;Mohamed, AbdAllah, & Shammat, 1997), fluorimetry (Dejaegher, Bloomfield, Smeyers-Verbeke, & Vander Heyden, 2008) to chromatographic techniques such as micellar electrokinetic chromatography (N emeth, Jankovics, N emeth-Palot as, & K} oszegi-Szalai, 2008) and several liquid chromatography techniques. The latter technique has also been variously adapted with regard to detection which includes amperometric (Wyszecka-Kaszuba, Waronwna-Grzeskiewicz, & Fijalek, 2001), voltametric (Liu, Li, Dong, & Wang, 1996), and spectrophotometric (Nageswara and Narasaraju, 2006).…”

Section: Introductionmentioning

confidence: 99%

A new method for the microdetermination of Para-aminophenol in generic brands of paracetamol tablets

Adegoke

Thomas

Amao

et al. 2019

Arab Journal of Basic and Applied Sciences

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In Nigeria, paracetamol is readily available in several retail outlets where the conditions of storage can be poor leading to elevated levels of para-aminophenol (PAP), which is known to be nephrotoxic and hepatotoxic. However, the routine analysis of PAP is mostly by chromatographic separation which requires expensive instrumentation not often available in developing countries. The objective of this research was to develop a sensitive colorimetric method for the quantification of PAP in paracetamol. The method was based on the diazo coupling reaction between diazotised PAP and chromotropic acid. Various reaction parameters critical for optimal detector response were optimized. The validation of the new method was done following the determination of parameters including repeatability, reproducibility and selectivity using current ICH guidelines. The new method was also applied to the assay of PAP in 14 paracetamol tablet samples. The calibration was linear between 0.0297 and 0.2229 mg/mL at 470 nm with limits of detection and quantification of 0.0061 and 0.0185 mg/mL, respectively. The recovery was in the range of 95.96 and 102.21 while intra-and inter-day precisions at three different concentrations did not exceed 4.03%. The new method was successfully applied to quantify PAP in paracetamol with percent content varying from 0.14 to 0.21%w/w. A simple and reliable method for the quantification of PAP has been developed and successfully employed to report, for the first time, the presence of the degradation product at levels beyond the allowable limits in paracetamol dosage forms in Nigeria.

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“…In some cases, [5][6][7] sample preparation is also needed. Electrochemical, 9,10 colorimetric 4,11,12 and spectrophotometric [13][14][15] methods have also previously been reported. The electrochemical methods for the detection of 4-AP suffer from interference from other active ingredients or additives especially those carrying phenolic or amine functional groups and, therefore, chromatographic separation is usually required.…”

Section: Introductionmentioning

confidence: 98%

Determination of 4-aminophenol using the quartz crystal microbalance sensor

Karousos

Reddy

2002

Analyst

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In this paper we report a method for the determination of 4-aminophenol (4-AP) in solution using a quartz crystal microbalance (QCM) sensor. 4-AP reacts with (para-unsubstituted) phenols to form hydrophobic indophenol dye species that precipitate out and adsorb to the surface of the crystal to produce a shift in the crystal resonant frequency. This frequency change, due to in-situ indophenol mass adsorption, can be related to the initial 4-AP concentration. A range of phenols (namely o-cresol, 1-naphthol, resorcinol, catechol and 8-hydroxyquinoline) and their reaction with 4-AP were tested. Ammonium persulfate (APS) and potassium periodate were used as initiators to improve the speed of the reaction and the rate of formation of the precipitate. APS elicited improved signal in terms of response times and frequency shifts compared with KIO4. Of the phenols studied, resorcinol gave the best response time of 6 min for 4-AP determination. The reaction of resorcinol with 4-AP gave extended response times and signal size with decreasing concentration of 4-AP (in the range 2-5 mM).

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Colorimetric determination of p-aminophenol in the presence of paracetamol with 3-cyano-N-methoxypyridinium perchlorate

Cited by 19 publications

References 6 publications

Advanced chemometric methods for simultaneous quantitation of caffeine, codeine, paracetamol, and p-aminophenol in their quaternary mixture

Advanced chemometric methods for simultaneous quantitation of caffeine, codeine, paracetamol, and p-aminophenol in their quaternary mixture

A new method for the microdetermination of Para-aminophenol in generic brands of paracetamol tablets

Determination of 4-aminophenol using the quartz crystal microbalance sensor

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