Colorimetric aptasensor targeting zearalenone developed based on the hyaluronic Acid-DNA hydrogel and bimetallic MOFzyme

Sun, Yuhan; Qi, Shuo; Qin, Mingwei; Zhang, Yin; Wang, Zhouping

doi:10.1016/j.bios.2022.114366

Cited by 31 publications

(10 citation statements)

References 28 publications

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“…Wang et al constructed a sensitive colorimetric aptasensor according to a hyaluronic acid (HA)–DNA hydrogel and MOF-based nanozyme (MOFzyme) for sensitive and precise quantification of zearalenone (ZEN). 346 The bimetallic MOFzyme was successfully prepared via partial oxidation of a Ce–Zr MOF. Simultaneously, the two metal nodes (IV) also exhibited a significant impact on the MOFzyme stability due to the adjustable crystal structure of MOFs.…”

Section: The Applications Of Mof-based Hydrogelsmentioning

confidence: 99%

Advances in metal–organic framework-based hydrogel materials: preparation, properties and applications

et al. 2023

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Section: The Applications Of Mof-based Hydrogelsmentioning

confidence: 99%

Advances in metal–organic framework-based hydrogel materials: preparation, properties and applications

et al. 2023

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“…Because of its significant pathogenicity and widespread distribution in animal feed ingredients and agricultural food, ZEN has emerged as a global public health concern. A colorimetric sensor combining hydrogel collapse and MOFzyme catalysis has successfully achieved high specificity and sensitivity for the detection of ZEN [ 165 ]. As MOFzyme has good oxidase activity, the presence of ZEN will lead to its exposure and catalyze the oxidation of TMB.…”

Section: Stimulus-responsive Dna Hydrogel Biosensors For Food Safety ...mentioning

confidence: 99%

Stimulus-Responsive DNA Hydrogel Biosensors for Food Safety Detection

Wang

Lai

et al. 2023

Biosensors

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Food safety has always been a major global challenge to human health and the effective detection of harmful substances in food can reduce the risk to human health. However, the food industry has been plagued by a lack of effective and sensitive safety monitoring methods due to the tension between the cost and effectiveness of monitoring. DNA-based hydrogels combine the advantages of biocompatibility, programmability, the molecular recognition of DNA molecules, and the hydrophilicity of hydrogels, making them a hotspot in the research field of new nanomaterials. The stimulus response property greatly broadens the function and application range of DNA hydrogel. In recent years, DNA hydrogels based on stimulus-responsive mechanisms have been widely applied in the field of biosensing for the detection of a variety of target substances, including various food contaminants. In this review, we describe the recent advances in the preparation of stimuli-responsive DNA hydrogels, highlighting the progress of its application in food safety detection. Finally, we also discuss the challenges and future application of stimulus-responsive DNA hydrogels.

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“…When the gel dissolves, the coated AuNPs are released, turning the whole solution system red. Therefore, AuNPs can be used to visually analyze the state changes of DNA-based hydrogels. − …”

Section: Bioanalysis and Therapeutics Applicationsmentioning

confidence: 99%

Intelligent DNA-Based Hydrogels for Bioanalysis and Therapeutics

Zhu,

Shen,

Chen

et al. 2023

ACS Appl. Polym. Mater.

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DNA is a type of biomacromolecule that can be modified and designed through enzymatic or chemical techniques, and it serves as both a biological reactive entity and a polymer. In recent years, with the rapid development of chemistry, material science, and nanotechnology, researchers began to look at the DNA molecule from another perspective. The exceptional ability of DNA-based materials for selective recognition and structural design has attracted much attention. With the development of nanotechnology, there is an urgent need for smart hydrogel materials with excellent biocompatibility. Among many nanomaterials, DNA is considered to be an excellent smart material, which can spontaneously self-assemble into a precise and ordered structure under optimal conditions. Chemical bonding between DNA molecules or physical entanglement between DNA strands can be prepared from DNA-based smart hydrogels. Compared with traditional hydrogels, DNA-based hydrogels have the characteristics of functional DNA molecular programming and high-precision assembly, multifunctionality, and excellent biocompatibility and retain the excellent mechanical properties and physical properties of hydrogels. It has attracted increasing research interest in various fields, especially in biosensing and biomedical applications. In this review, we highlight the advances in DNA-based hydrogels for bioanalysis and therapeutics. We first summarize the construction methods and basic properties of DNA-based pure and hybrid hydrogels and discuss their research progress and biological applications. Subsequently, the practical applications of various types of DNA-based hydrogels in the fields of bioanalysis and drug delivery are described through some selected examples. Finally, the remaining challenges and prospects of DNA-based hydrogels are discussed in depth.

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Colorimetric aptasensor targeting zearalenone developed based on the hyaluronic Acid-DNA hydrogel and bimetallic MOFzyme

Cited by 31 publications

References 28 publications

Advances in metal–organic framework-based hydrogel materials: preparation, properties and applications

Advances in metal–organic framework-based hydrogel materials: preparation, properties and applications

Stimulus-Responsive DNA Hydrogel Biosensors for Food Safety Detection

Intelligent DNA-Based Hydrogels for Bioanalysis and Therapeutics

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