Colorectal lymphoma in Mexico: clinico-pathological and survival analysis

Jaime-Andrade, Everardo; Lino-Silva, Leonardo S.; Salcedo‐Hernández, Rosa A.; Zepeda-Najar, César

doi:10.21037/jgo.2017.10.08

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…Our study showed a male predominance, which correlates well with the results of most of the previous studies. As observed in other studies, histologically, the most common subtype of lymphoma in the colon is NHL 2 ; the most common subtype of lymphoma found in our study was DLBCL, which is similar to that reported in previous studies (43–63%) 8,13,28,32,33 . According to the WHO Classification of Tumors of the Digestive System Tumors , Fifth edition, the majority of colorectal lymphomas (>50%) are DLBCLs, which includes immunodeficiency‐associated cases, followed by MALT, FL, MCL, and Burkitt lymphomas 23,34 .…”

Section: Discussionsupporting

confidence: 90%

“…As observed in other studies, histologically, the most common subtype of lymphoma in the colon is NHL 2 ; the most common subtype of lymphoma found in our study was DLBCL, which is similar to that reported in previous studies (43–63%). 8 , 13 , 28 , 32 , 33 According to the WHO Classification of Tumors of the Digestive System Tumors , Fifth edition, the majority of colorectal lymphomas (>50%) are DLBCLs, which includes immunodeficiency‐associated cases, followed by MALT, FL, MCL, and Burkitt lymphomas. 23 , 34 The frequency of DLBCL, MCL, and FL was high in the present study; however, the frequency of MALT lymphoma was lower than the frequency reported by the WHO.…”

Section: Discussionmentioning

confidence: 99%

“…23 The difference between previous reports and our study may be attributed to the fact that our hospital, being a cancer center, consults patients with many different types of malignant lymphoma; also, our study included only Japanese patients. The most common location of colorectal lymphoma is the cecum, occurring in 30–60% of patients, 5 , 8 , 9 , 10 , 11 , 14 , 29 , 32 , 35 , 36 followed by that of the sigmoid and rectum, which accounts for 10–25% of the colorectal lymphomas. In this study, the most common sites observed were the cecum and rectum.…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic features of colorectal lymphoma according to histological type

et al. 2022

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Background and Aim This study aimed to investigate the relationship between the histological type of colorectal lymphoma and its endoscopic features. Methods We retrospectively analyzed patients with primary colorectal lymphoma who were diagnosed using colonoscopy and biopsy specimens at the National Cancer Center Hospital, Tokyo, Japan. The lesions were macroscopically classified into the following types via colonoscopy: polypoid, ulcerative, multiple lymphomatous polyposis, diffuse, and mixed. Results A total of 117 lesions were identified in 90 patients enrolled in this study. Of these, 59 (50%) were located in the ileocecal region, 23 (20%) in the rectum, 9 (8%) in the transverse colon, 8 (7%) in the sigmoid colon, 7 (6%) in the descending colon, and 4 (3%) in the ascending colon. Moreover, the most common histological subtypes were diffuse large B‐cell lymphoma (DLBCL) in 39 patients (43%) and mantle cell lymphoma (MCL) in 23 patients (26%), followed by follicular lymphoma (FL; 17%), mucosa‐associated lymphoid tissue (MALT) lymphoma (9%), peripheral T‐cell lymphoma‐NOS (2%), monomorphic epitheliotropic intestinal T‐cell lymphoma (MEITL; 2%), and Burkitt lymphoma (1%). More than half of the DLBCL (52%), MCL (52%), and MALT (56%) lymphomas were macroscopically classified as polypoid types. In contrast, FL lesions showed various macroscopic types. The majority of DLBCL (62%) and FL (78%) lesions were distributed in the ileocecal region. MCL lesions tended to be widely spread in various sites of the large intestine. Conclusions Colorectal lymphomas showed macroscopically distinctive features depending on the histological type. Understanding the macroscopic classification of the lesions by colonoscopy and its distribution may be helpful in diagnosing the type of lymphoma and determining the malignant grade based on the histological types.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Endoscopic features of colorectal lymphoma according to histological type

et al. 2022

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“…In contrast, in advanced disseminated disease (Stage IV), there was no significant difference in progression-free survival (PFS) or OS between the two strategies [P-value >0.05]. Comparable results were reported by Jaime-Andrade et al (18) as their study showed improved survival in cases that underwent surgery followed by chemotherapy. These results are consistent with those of the current study, as the 5-years OS improved in cases that underwent surgery compared to those that did not [(90.6% vs. 64.7%, respectively) P-value= 0.013].…”

Section: Resultsmentioning

confidence: 96%

Exploring The Prognostic Significance of Lymphoma in Colon and Rectum, National Cancer Institute Experience, Egypt

ElKordy¹,

ElMesseh²,

ElGammal³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Colorectal cancer is one of the commonest types of malignancies. Lymphoma is a rare occurrence in this population, with adenocarcinoma constituting the majority of cases. Few publications have analysed the clinicopathological behaviour of colorectal lymphoma (CL). Both the effect of systemic therapy in these cases and the significance of surgical resection of these tumours remain unclear. Objective: The aim of the current study is to address CL from the perspectives of demographic, clinical characteristics, diagnosis and treatment, as well as studying prognosis. Patients and methods: The current retrospective cohort study included all cases diagnosed with CL and managed at the National Cancer Institute, Cairo University, during the period from 2010 to 2021. The data included demographic, clinical presentation, investigation used and their results, treatment modalities used, and prognosis. Results: Throughout the duration of the study, 49 patients were diagnosed with CL and treated in the National Cancer Institute. Patients' ages ranged between 2 and 70 years, with a median of 5 years. Burkitt lymphoma was the most common type (71%). Most of the cases (63.3%) were aroused in ascending colon. Early stages (Stages I and II) accounted for 81.6% of the cases. Before chemotherapy, 32 cases (65.3%) underwent surgical resection. The absence of B symptoms, Hg ≥10 gm/dl, and surgically treated cases were associated with a favourable prognosis. Conclusion:The incidence of lymphoma affecting the colon and rectum is uncommon. Patients' ages upon presentation vary, and it typically originates in the right colon. In combination with systemic therapy, surgical excision of the tumour appears to improve survival in the early stages.

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