Background: Colorectal cancer is one of the commonest types of malignancies. Lymphoma is a rare occurrence in this population, with adenocarcinoma constituting the majority of cases. Few publications have analysed the clinicopathological behaviour of colorectal lymphoma (CL). Both the effect of systemic therapy in these cases and the significance of surgical resection of these tumours remain unclear. Objective: The aim of the current study is to address CL from the perspectives of demographic, clinical characteristics, diagnosis and treatment, as well as studying prognosis. Patients and methods: The current retrospective cohort study included all cases diagnosed with CL and managed at the National Cancer Institute, Cairo University, during the period from 2010 to 2021. The data included demographic, clinical presentation, investigation used and their results, treatment modalities used, and prognosis. Results: Throughout the duration of the study, 49 patients were diagnosed with CL and treated in the National Cancer Institute. Patients' ages ranged between 2 and 70 years, with a median of 5 years. Burkitt lymphoma was the most common type (71%). Most of the cases (63.3%) were aroused in ascending colon. Early stages (Stages I and II) accounted for 81.6% of the cases. Before chemotherapy, 32 cases (65.3%) underwent surgical resection. The absence of B symptoms, Hg ≥10 gm/dl, and surgically treated cases were associated with a favourable prognosis. Conclusion:The incidence of lymphoma affecting the colon and rectum is uncommon. Patients' ages upon presentation vary, and it typically originates in the right colon. In combination with systemic therapy, surgical excision of the tumour appears to improve survival in the early stages.
Background: Pancreaticoduodenectomy (PD), a complex operation with a high morbidity rate, especially pancreatic fistula, is still the standard treatment for resectable pancreatic head, ampullary, distal bile duct, and duodenal tumours. Despite improvements in pancreatic fistula detection and treatment, it still has a significant death rate. As a result, it is critical to address the causes of pancreatic fistula for which this study was created.Objective: This study aimed to address the different risk factors affecting the incidence of pancreatic leakage post pancreaticoduodenectomy. Subjects and Methods: This is a retrospective case-control study that included all cases that experienced pancreaticoduodenectomy during the period from January 2014 to December 2021 at the National Cancer Institute (NCI), Cairo University. The cases have been categorized into two groups (cases who developed pancreatic leakage and those who did not develop it). Both groups were compared for the possible risk factors: age, gender, tumour size, LNs positivity, laboratory findings (HB, Albumin), neoadjuvants received, surgical techniques (anastomosis technique, vein resection, texture of pancreatic remnant), and postoperative nutrition plan used. Results: Ninety-five cases of pancreaticoduodenectomy were done during the study period. Among them, 35 cases had developed postoperative pancreatic fistula (POPF). A significantly higher pancreatic fistula incidence was associated with the female gender, preoperative haemoglobin levels of < 12 gm/dl and albumin levels of < 3.6 gm/dl, along with soft pancreatic texture. Conclusion:Pancreaticoduodenectomy is an operation with a high morbidity rate. Female gender, low HB and albumin levels, and soft pancreatic texture are risk factors for developing pancreatic fistula.
Background: Gastric cancer has long been assumed to be more advanced and has a worse prognosis in younger people than in older ones. This assumption, however, has never been validated, most likely attributable to the lack of patient numbers for a stage-by-stage survival comparison. Objectives: To present NCI, Cairo University experience in managing young patients (≤ 40 years) with gastric adenocarcinoma Patients and methods: Retrospective cohort study included all cases diagnosed in NCI with gastric adenocarcinoma at or below the age of 40 years in the period from 2010 to 2021. The data included demographic attributes, clinical presentation, investigations and results, adopted treatment modalities, and prognosis of these cases. Results: During the period of the study, 30 cases of gastric adenocarcinoma with ages of around 40 years or less have been diagnosed and managed in NCI. Most cases presented in an advanced stage as stage 4 represented 46.7% (14 cases). Seventeen cases (56.7%) underwent surgical exploration, where chemotherapy was taken for twenty-six cases (86.7%). The overall survival showed that patients presented with advanced stage, had omental deposits or ascites had a worse prognosis (P-value = 0.001, <0.001, <0.001 respectively). Additionally, cases who underwent surgery or received chemotherapy had better overall survival than those who did not have (P-value = 0.001, <0.001, respectively). Conclusion: Gastric Cancer is aggressive in young age and presents mainly in advanced stage. In terms of overall survival, patients benefit significantly from combined treatment modalities (chemotherapy and surgical resection) compared to receiving only one treatment option.
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