Colorectal liver metastases: disappearing lesions in the era of Eovist hepatobiliary magnetic resonance imaging

Owen, Joseph W.; Fowler, Kathryn J.; Doyle, Maria B. Majella; Saad, Nael; Linehan, David C.; Chapman, Will

doi:10.1016/j.hpb.2015.10.009

Cited by 51 publications

(40 citation statements)

References 17 publications

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“…Contrast‐enhanced intraoperative ultrasonography (CE‐IOUS) has also been shown to provide significant information in intraoperative diagnosis . Although the efficacy of addition of these new imaging modalities to detect DLMs has been reported in several studies, it remains unclear how these available imaging modalities can be used effectively to detect DLMs after chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Management of disappearing lesions after chemotherapy for colorectal liver metastases: Relation between detectability and residual tumors

Tani

Shindoh

Akamatsu

et al. 2017

Journal of Surgical Oncology

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Section: Introductionmentioning

confidence: 99%

Management of disappearing lesions after chemotherapy for colorectal liver metastases: Relation between detectability and residual tumors

Tani

Shindoh

Akamatsu

et al. 2017

Journal of Surgical Oncology

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“…Despite a complete response on imaging, many studies have shown persistent viable tumor cells at the site of the "disappearing lesions". With a lesion based analysis, the incidence of disappearing lesions ranges from 11% to 36% of initially detected CRCLM, and half of these lesions can present persistent disease, which may have great impact on patient relapse as well as on survival (25)(26)(27).…”

Section: Ricardo Jorge Teixeira Martins and José Guilherme Lopes Rodrigmentioning

confidence: 99%

Synchronous Liver Metastases from Colorectal Cancer: State of the Art

Martins¹,

Tralhão²

2019

SGO

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Colorectal cancer (CRC) is one of the most common cancers in the world and a leading cause of death. The liver is the dominant metastatic site for patients with CRC, and approximately 50% of patients develop CRC liver metastases (CRCLM) during the course of their disease. Surgical resection, when combined with chemotherapy, can achieve 5-year overall survival (OS) rates of up to 40-60% for patients with CRCLM. Despite excellent results, recurrence-free survival rates remain low as many surviving patients eventually experience recurrence. Appropriate patient selection is the key to ensure the best perioperative and long-term oncologic outcomes. Synchronous CRCLM are detected at the same time or before the diagnosis of the primary tumor. In general these patients present with a higher tumor burden, more extensive liver disease, and a more aggressive presentation. The 5-year OS rate in patients with synchronous CRCLM is around 40%, and specific approaches for the decision-making process are mandatory according to the tumor status and resectability at both organ sites. When appropriate and technically feasible, the simultaneous surgical resection approach to synchronous CRCLM should be preferred as it is safe and effective and provides for substantial financial cost savings. Neoadjuvant chemotherapy should be used with precaution, since it can result in lesions "disappearing" or becoming imaging occult. Moreover, the risk of operative morbidity increases with the number of prior chemotherapy cycles. A short period of conversion chemotherapy is recommended, and multidisciplinary discussions of the treatment strategy should be scheduled every two months. An individualized and patient-tailored multidisciplinary approach is mandatory, when trying to define the best treatment of synchronous CRCLM.

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“…Nevertheless, visual servoing raises several limitations, in particular for the needle insertion: 1) Per-operative images usually offer poor visibility of internal structures (such as a tumor or vessels), and it is very challenging to extract essential data at high frequency. This is especially true for disappearing liver metastases: due to chemotherapy effects, the shape of tumors may change or they may become invisible in intraoperative images, even if the lesions still contain active tumors [4]. 2) When large deformations occur the control law of the robot can be significantly modified which is extremely difficult to relate with image-based displacements.…”

Section: Introductionmentioning

confidence: 99%

Robotic Insertion of Flexible Needle in Deformable Structures Using Inverse Finite-Element Simulation

et al. 2019

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Colorectal liver metastases: disappearing lesions in the era of Eovist hepatobiliary magnetic resonance imaging

Abstract: Despite disappearance on Eovist MR imaging (the most sensitive available imaging modality), 38.5% of all colorectal metastases disappeared and of those, 55% were viable.

Cited by 51 publications

References 17 publications

Management of disappearing lesions after chemotherapy for colorectal liver metastases: Relation between detectability and residual tumors

Management of disappearing lesions after chemotherapy for colorectal liver metastases: Relation between detectability and residual tumors

Synchronous Liver Metastases from Colorectal Cancer: State of the Art

Robotic Insertion of Flexible Needle in Deformable Structures Using Inverse Finite-Element Simulation

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