Colorectal Carcinoma Metastases in Liver: Laser-induced Interstitial Thermotherapy—Local Tumor Control Rate and Survival Data

Vogl, Thomas J.; Straub, Roland; Eichler, Katrin; Söllner, O.; Mack, Martin G.

doi:10.1148/radiol.2302020646

Cited by 257 publications

(163 citation statements)

References 54 publications

(41 reference statements)

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“…Photothermal reactions (that is, photothermal ablation) uses heat generated through absorption of light to directly destroy tissue. Photothermal ablation as a minimally invasive treatment has been used successfully for ablation of tumors throughout the body, especially liver lesions (1,4). However, this therapy approach, like other thermal delivery methods, such as radiofrequency (5), microwave (6), and focused ultrasound ablation therapies (7,8), is limited by the same fact that the heating from these energy sources is nonspecific.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy

Melancon¹,

Lü²,

Liu³

et al. 2008

Molecular Cancer Therapeutics

380

422

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy

Melancon¹,

Lü²,

Liu³

et al. 2008

Molecular Cancer Therapeutics

380

422

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“…Recurrence appears to be mainly due to micrometastases that already exist at the time of resection [6], which may rapidly grow up to macrometastases. Thus, in-situ ablation procedures, such as laserinduced thermotherapy (LITT), are gaining in clinical importance in the primary and secondary treatment of liver tumors [7,8]. The largest series of patients worldwide with laser-ablated colorectal liver metastases (n ¼ 603) by Vogl et al [8] gives a 5-year survival rate of 37% despite relatively unfavorable prognostic factors.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, in-situ ablation procedures, such as laserinduced thermotherapy (LITT), are gaining in clinical importance in the primary and secondary treatment of liver tumors [7,8]. The largest series of patients worldwide with laser-ablated colorectal liver metastases (n ¼ 603) by Vogl et al [8] gives a 5-year survival rate of 37% despite relatively unfavorable prognostic factors. Compared to hepatic resection, LITT is deemed to be a parenchymasaving procedure shown to influence residual intrahepatic and extrahepatic tumor growth [9].…”

Section: Introductionmentioning

confidence: 99%

Laser‐induced thermotherapy (LITT) elevates mRNA expression of connective tissue growth factor (CTGF) associated with reduced tumor growth of liver metastases compared to hepatic resection

et al. 2006

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Background and Objectives: Proliferation and synthesis of hepatocellular tissue after tissue damage are promoted by specific growth factors such as hepatic tissue growth factor (HGF) and connective growth factor (CTGF). Laser-induced thermotherapy (LITT) for the treatment of liver metastases is deemed to be a parenchyma-saving procedure compared to hepatic resection. The aim of this study was to compare the impact of LITT and hepatic resection on intrahepatic residual tumor tissue and expression levels of mRNA HGF/CTGF within liver and tumor tissue. Study Design/Materials and Methods: Two independent adenocarcinomas (CC531) were implanted into 75 WAG rats, one in the right (untreated tumor) and one in the left liver lobe (treated tumor). The left lobe tumor was treated either by LITT or partial hepatectomy. The control tumor was submitted to in-situ hybridization of HGF and CTGF 24-96 hours and 14 days after intervention. Results: Volumes of the untreated tumors prior to intervention were 38 AE 8 mm 3 in group I (laser), 39 AE 7 mm 3 in group II (resection), and 42 AE 12 mm 3 in group III (control) and did not differ significantly (P > 0.05). Fourteen days after the intervention the mean tumor AE SEM volume of untreated tumor in group I (laser) [223 AE 36] was smaller than in group II (resection) [1233.28 AE 181.52; P < 0.001], and in group III (control) [978.92 AE 87.57; P < 0.003]. Forty-eight hours after the intervention intrahepatic mRNA expression level of HGF in group II (resection) was almost twofold higher than in group I (laser) [7.2 AE 1.0 c/mf vs. 3.9 AE 0.4 c/mf; P < 0.01]. Fourteen days after the intervention intrahepatic mRNA expression level of CTGF in group I (laser) was higher than in group II (resection) [13.89 AE 0.77 c/mf vs. 9.09 AE 0.78 c/mf; P < 0.003]. Conclusions: LITT leads to a decrease of residual tumor growth in comparison to hepatic resection. Accelerated tumor growth after hepatic resection is associated with higher mRNA level of HGF and reduced tumor growth after LITT with higher mRNA level of CTGF. The increased CTGF-mediated regulation of ECM may cause reduced residual tumor growth after LITT.

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“…Radiofrequency waves , cryotherapy (Sotsky and Ravikumar, 2002), lasers (Vogl et al, 2004), microwave energy (Shibata et al, 2002), ethanol injection (Livraghi et al, 1995) and high-intensity focused ultrasound (HIFU) (Kennedy, 2005) have all been used to ablate tumours; however, HIFU remains the only modality to be completely extracorporeal.…”

mentioning

confidence: 99%

The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population

et al. 2005

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High-intensity focused ultrasound (HIFU) provides a potential noninvasive alternative to conventional therapies. We report our preliminary experience from clinical trials designed to evaluate the safety and feasibility of a novel, extracorporeal HIFU device for the treatment of liver and kidney tumours in a Western population. The extracorporeal, ultrasound-guided Model-JC Tumor Therapy System (HAIFUt Technology Company, China) has been used to treat 30 patients according to four trial protocols. Patients with hepatic or renal tumours underwent a single therapeutic HIFU session under general anaesthesia. Magnetic resonance imaging 12 days after treatment provided assessment of response. The patients were subdivided into those followed up with further imaging alone or those undergoing surgical resection of their tumours, which enabled both radiological and histological assessment. HIFU exposure resulted in discrete zones of ablation in 25 of 27 evaluable patients (93%). Ablation of liver tumours was achieved more consistently than for kidney tumours (100 vs 67%, assessed radiologically). The adverse event profile was favourable when compared to more invasive techniques. HIFU treatment of liver and kidney tumours in a Western population is both safe and feasible. These findings have significant implications for future noninvasive image-guided tumour ablation.

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Colorectal Carcinoma Metastases in Liver: Laser-induced Interstitial Thermotherapy—Local Tumor Control Rate and Survival Data

Abstract: MR imaging-guided LITT yields high local tumor control and survival rates in well-selected patients with limited liver metastases of colorectal carcinoma.

Cited by 257 publications

References 54 publications

In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy

In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy

Laser‐induced thermotherapy (LITT) elevates mRNA expression of connective tissue growth factor (CTGF) associated with reduced tumor growth of liver metastases compared to hepatic resection

The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population

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