Colorectal carcinoma associated with schistosomiasis: a possible causal relationship

Abstract

The association between schistosomiasis and colorectal malignancy has long been suggested in the literature, but it is not uniformly accepted. In the Far East, considerable evidence supports an etiological link between Schistosoma japonicum and colorectal cancer. However, the available data regarding the role of Schistosoma mansoni in colorectal carcinogenesis are conflicting and most often do not show causality. We report on a patient with sigmoid colonic cancer coexisting with schistosomiasis, and we provide a comprehensive review of the literature regarding the epidemiology and pathobiology of this association.

Schistosomiasis Combined with Colorectal Carcinoma Diagnosed Based on Endoscopic Findings and Clinicopathological Characteristics: A Report on 32 Cases

“…Additionally, men are more prone to schistosomal infection through contact with cercariae-infested waters during agricultural activities (Salim et al, 2010). In this study, schistosomiasis combined with CRC was more common in males than in females (M:F ratio, 3:1), which was in keeping with previous observations reported in studies performed elsewhere (Madbouly et al, 2007).…”

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

“…From another point of view, the problem of bilharziasis and its various aspects needs careful clinical studies to clarify its effect on the biochemical features of tumour development (Salim et al 2010). In the present study, LDH showed a significant elevation by 93.90%, 169.29% and 36.95 % in colon cancer, bilharzial-related colon cancer and intestinal schistosomiasis colon tissue, respectively.…”

“…In other African countries, where S. haematobium are endemic, severe intestinal involvement is not frequent. In China, a high incidence of colorectal cancer in regions with endemic S. japonicum was recorded, where patients with chronic Schistosomiasis japonica have a more than three times greater risk of developing colon cancer than those with no previous exposure to schistosomal infection (Salim et al 2010). Therefore, the difference in parasite strains, intensity of infection, concomitant infections (including S. haematobium) and environmental conditions may be important in determining the varying patterns of the disease (Cheever & Andrade 1967).…”

“…Colonic schistosomiasis is a specific acute or chronic inflammatory reaction in response to Schistosoma ova that are deposited mainly in colorectal mucosa (Cao et al 2010, Salim et al 2010. Most of the published data refer to Schistosoma japonicum species in the induction of colonic cancer, but the evidence linking Schistosoma mansoni to colonic carcinoma occurrence is limited (Salim et al 2010).…”

“…Most of the published data refer to Schistosoma japonicum species in the induction of colonic cancer, but the evidence linking Schistosoma mansoni to colonic carcinoma occurrence is limited (Salim et al 2010). …”