Colorectal cancer risk factors in patients with serrated polyposis syndrome: a large multicentre study

Carballal, Sabela; Rodríguez‐Alcalde, Daniel; Moreira, Leticia; Hernández, Luis; Rodríguez, Lorena; Rodríguez-Moranta, Francisco; Gonzalo, Victoria; Bujanda, Luís; Bessa, Xavier; Povés, Carmen; Cubiella, Joaquín; Castro, Inês; González, Mercedes E.; Moya, Eloisa; Oquiñena, Susana; Clofent, Joan; Quintero, Enrique; Esteban, Pilar; Piñol, Virgı́nia; Fernández, Francisco Javier; Jover, Rodrigo; Cid, Lucía; López-Cerón, María; Cuatrecasas, Míriam; López-Vicente, Jorge; Leoz, Maria Liz; Rivero‐Sánchez, Liseth; Castells, Antoni; Pellisé, María; Balaguer, Francesc

doi:10.1136/gutjnl-2015-309647

Cited by 99 publications

(137 citation statements)

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“…At this stage, it is unknown whether geographical differences exist within countries, potentially due to environmental and/or genetic factors, such as diet or smoking habits, justifying the conception of an international study. Second, international studies are needed to enable a proper assessment of the prevalence of individuals with serrated polyposis syndrome (SPS), a syndrome characterised by multiple SPs throughout the colon and accompanied by an increased risk of developing CRC 12 22 23. The aim of this study was to evaluate and compare the detection rate (referred to as rate) of SP subtypes as well as SPS in several European CRC screening cohorts in an attempt to better understand what is reported among Western countries and to enable guidance for detection standards.…”

Section: Introductionmentioning

confidence: 99%

Detection rate of serrated polyps and serrated polyposis syndrome in colorectal cancer screening cohorts: a European overview

IJspeert

Bevan

Senore

et al. 2016

Gut

115

102

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Section: Introductionmentioning

confidence: 99%

Detection rate of serrated polyps and serrated polyposis syndrome in colorectal cancer screening cohorts: a European overview

IJspeert

Bevan

Senore

et al. 2016

Gut

115

102

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“…A recent multicenter study described a CRC risk of 15%, lower than previously reported, with some specific polyp features associated with a higher risk [61].…”

Section: Serrated Polyposis Syndromementioning

confidence: 79%

Surveillance of patients with hereditary gastrointestinal cancer syndromes

Moreira

Castells

2016

Best Practice & Research Clinical Gastroenterology

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“…Thus, Boparai and his colleagues reported that in 35 % of such cases (27 of 77) the SPS was found, and CRC was found in 6.5 % (5 of 77) of those patients [41]. Carballal and colleagues recently reported that the presence of more than two SSA/P, which are more proximal to the splenic fl exure, and one SSA/P in proximal colon with high-grade dysplasia were independent risk factors for CRC (incremental OR=2.95 % CI=1.22-3.24, p=0.006) in patients with SPS [42].…”

Section: Serrated-polyposis Syndrome (Sps)mentioning

confidence: 99%

Serrated polyps as precursor lesions of colorectal cancer: current status and future directions. Mini-review.

Kuzo

2016

Patologìâ

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Early diagnosis of colorectal cancer (CRC) is a very urgent problem, since this disease has second place among women and the third one among men in the structure of cancer pathology. According to recent data, CRC should be considered as a heterogeneous multifactorial family of diseases with different variants.Serrated polyps of the colon are obligate precancerous condition, which can transform into cancer due to genetic aberrations. Serrated polyps are a heterogeneous group of formations with different ways of appearance and potential malignancy. They are divided into major subtypes: hyperplastic polyps, sessile serrated adenoma/polyp and traditional serrated adenoma.The purpose of the study was the analysis of current data about mechanisms of formation and malignization of serrated colonic polyps.The relationship between the localization of serrated polyps and their morphology was identifi ed. Polyps located in the proximal colon are characterized by a more expressed degree of serration in the basal segment of crypts compared with polyps located in the distal part of the colon. The difference between the proximal and distal localization was confi rmed by molecular genetic testing: the majority of proximal serrated polyps develops after BRAF mutations, and the majority of polyps with distal localization develops after a KRAS mutation.It is known that a key role in the excessive proliferation and inhibition of apoptosis in the process of malignant transformation of serrated polyps is provided by the combination of different types of genome damage, both genetic and epigenetic. Molecular changes are already present in the early stages of cell dysplasia in serrated colon polyps, and their nature determines the malignant potential.Conclusions. A thorough study of the molecular mechanisms of progression along the serrated pathway and transformation of serrated polyps in the CRC opens up prospects for the development of guidelines for patient management in order to prevent the development of serrated pathway cancers. Зубчасті поліпи як прекурсор розвитку раку товстої кишки: сучасний погляд і перспективи. Міні-огляд І. О. КузьоСвоєчасна діагностика раннього раку товстої кишки є вкрай актуальним питанням сучасності, оскільки це захворювання посідає друге місце серед жінок і третє серед чоловіків у структурі онкологічної патології. Згідно з результатами останніх досліджень, рак товстої кишки слід розглядати як гетерогенну, мультифактор-зумовлену групу захворювань із різними варіан-тами перебігу.Зубчасті поліпи товстої кишки є облігатним передраковим станом. У зв'язку з цим у світі активно вивчаються молекуляр-но-генетичні та імуноморфологічні аспекти їхнього злоякісного потенціалу. Сьогодні дослідники визнають: зубчасті поліпи товстої кишки можуть малігнізуватися шляхом послідовної трансформації, що зумовлена генетичними абераціями.Мета роботи -аналіз сучасних даних щодо механізмів формування та малігнізації зубчастих поліпів товстої кишки. Зубчасті поліпи є гетерогенною групою утворень, що мають різні шляхи розвитку та з...

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Colorectal cancer risk factors in patients with serrated polyposis syndrome: a large multicentre study

Cited by 99 publications

References 46 publications

Detection rate of serrated polyps and serrated polyposis syndrome in colorectal cancer screening cohorts: a European overview

Detection rate of serrated polyps and serrated polyposis syndrome in colorectal cancer screening cohorts: a European overview

Surveillance of patients with hereditary gastrointestinal cancer syndromes

Serrated polyps as precursor lesions of colorectal cancer: current status and future directions. Mini-review.

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