Colorectal cancer in the young: a 12‐year review of patients 30 years or less

Kam, Ming Hian; Eu, Kong‐Weng; Barben, Christopher; Seow‐Choen, Francis

doi:10.1111/j.1463-1318.2004.00596.x

Cited by 61 publications

(51 citation statements)

References 10 publications

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“…Another unexplained characteristic of early onset CRC is aggressive biological behavior. Advanced stage at presentation, high grade histology, and poor prognosis are features of early onset CRC that have been reported in case series from around the world [8][9][10][11][12][13][14]. Taken together, these data strongly suggest that among these patients are one or more undiscovered genetic syndromes.…”

Section: Introductionmentioning

confidence: 65%

Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer

Khan

Idrees

Forslund

et al. 2008

Journal of Surgical Oncology

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Section: Introductionmentioning

confidence: 65%

Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer

Khan

Idrees

Forslund

et al. 2008

Journal of Surgical Oncology

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“…Le sexratio était de 1,35 dans notre série. Cette prédominance masculine a été rapportée par plusieurs séries [3,[6][7][8]. Le risque de cancer colorectal augmente en cas de présence d'antécédents familiaux de cancer colorectal, de polypose familiale ou de RCH.…”

Section: Discussionunclassified

Colorectal carcinoma in patients younger than 40 years of age: about 40 cases

et al. 2010

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Le cancer colorectal chez le sujet jeune est une affection rare et de mauvais pronostic. Plusieurs études ont objectivé l'augmentation de son incidence et l'agressivité de la tumeur. Le but de ce travail est d'étudier les caractéristi-ques épidémiologiques, anatomocliniques, thérapeutiques et évolutives afin d'évaluer les facteurs de mauvais pronostic chez cette jeune population. Dans une étude rétrospective, portant sur 144 cas de cancers colorectaux, 40 patients, porteurs de cancer colorectal, étaient âgés de moins de 40 ans. Des antécédents prédisposant au cancer colorectal étaient présents chez 20 % des patients. La symptomatologie clinique était dominée par les rectorragies, suivies du syndrome rectal. La tumeur était rectale chez 70 % des patients et colique dans 30 % des cas. Un adénocarcinome peu différen-cié était retrouvé dans 25 % des cas, un adénocarcinome mucineux dans 2,5 % des cas et un contingent colloïde muqueux dans 7,5 % des cas. Le stade B était retrouvé dans 45 % des cas, le stade C dans 25 % des cas et le stade D dans 30 % des cas. La survie globale de nos patients était de 12,5 % à cinq ans. L'amélioration pronostique et thérapeutique du cancer colorectal, chez le sujet jeune, passe par un dépistage familial, une étude génétique par biologie moléculaire et un diagnostic précoce en présence d'antécédents prédisposant.Abstract Colorectal carcinoma in patients younger than 40 years is a rare affection which has a bad prognosis. Several studies have shown the increase in its impact and the aggressiveness of the tumour. The object of this work is to study the epidemiologic, anatomoclinic, therapeutic and evolutionary characteristics and to evaluate the factors of bad prognosis in this young population. In a retrospective review of 144 patients with colorectal cancer, 40 patients were under the age of 40. The predisposing antecedents of colorectal carcinoma were noted among 20 % of the cases. The clinical symptomatology was dominated by rectal bleeding and rectal pain. The tumour was rectal in 70 % and colic in 30 %. The cancers were poorly differentiated in 25 % of the cases, 2.5 % had mucinous adenocarcinoma and 7.5 % had mucosal colloid carcinoma. Stage B was found in 45 %, Stage C in 25 % and Stage D in 30 % of the cases. The overall survival rate was 12.5 % at 5 years. The prognostic and therapeutic improvement requires a family screening, a genetic analysis and an early diagnosis, when predisposing antecedents exist.

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“…This distinct feature has already been documented in the old literature (Scholefield 1946;Hoerner 1958). Several cases of liver metastases in pediatric colorectal carcinoma have been reported (Ko et al 1995;Karnak et al 1999;Ameh and Nmadu 2000;Kam et al 2004;Hill et al 2007;Pandey et al 2008). Due to the small number of cases observed in children, it is currently not known whether the propensity to metastasize to the liver is similar to or different from CRCs of the adult age group, but CRC in young individuals is rapidly progressive, with a high rate of recurrence, both local and remote.…”

Section: Liver Metastases In Pediatric Colorectal Carcinomamentioning

confidence: 95%