Colorectal Cancer: A Collaborative Approach to Improve Education and Screening in a Rural Population

Woodall, M. Neil; DeLetter, Mary

doi:10.1188/18.cjon.69-75

Cited by 8 publications

(14 citation statements)

References 12 publications

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“…Mature lncRNA may be located in the mRNA noncoding regions (3′-UTR or introns area) of their target gene, and may result in complete or incomplete complementary pairing, degradation or inhibition of mRNA translation and post-transcriptional alterations in gene expression. They may also participate in the regulation of cell differentiation, proliferation, apoptosis, and tissue and organ development (5,7,17).…”

Section: Discussionmentioning

confidence: 99%

“…Colorectal cancer is a malignant tumor caused by multiple factors, including individual genetics and environmental effects. For example, large-scale genetic studies have identified that the occurrence of colorectal cancer is associated with multiple genes abnormal expression and multiple molecular interactions (5–7), but the studies investigating the molecular mechanism of colorectal cancer incidence are not exhaustive. Therefore, additional studies exploring the pathogenesis of colorectal cancer may provide the theoretical basis for novel clinical anti-tumor drugs (8).…”

Section: Introductionmentioning

confidence: 99%

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LncRNA SNHG6 inhibits cell proliferation and metastasis by targeting ETS1 via the PI3K/AKT/mTOR pathway in colorectal cancer

et al. 2019

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The term 'long non-coding rnas' (lncrnas) refers to all non-protein coding transcripts >200 nucleotides in length. Dysregulation of lncRNAs has been identified in colorectal cancer, which is one of the more serious types of cancer worldwide, third place in the mortality rates, and is associated with poor prognoses. novel evidence suggests that lncrnas serve an important role in regulating the development and progression of colorectal cancer. in the present study, it was demonstrated that SnHG6 expression was downregulated in colorectal cancer tissues by reverse transcription quantitative polymerase chain reaction assays; however, eTS1 expression levels were upregulated. overexpression of SnHG6 not only inhibited the proliferation of colon cancer cells in vitro by inducing apoptosis, but also inhibited cell proliferation, invasion and migration. The overexpression of SnHG6 inhibited colon cell viability and proliferation by targeting eTS1 through the phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin signaling pathway. These results suggested that SnHG6 may directly suppress eTS1, which may be one of potential mechanisms through which it inhibits the viability and proliferation of colorectal cancer cells, and it provides novel insight into the carcinogenesis of colorectal cancer. in addition, it may assist in the development of a treatment approach for eTS1-activated colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

LncRNA SNHG6 inhibits cell proliferation and metastasis by targeting ETS1 via the PI3K/AKT/mTOR pathway in colorectal cancer

et al. 2019

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“…Some programs focused recruitment on participants with certain characteristics, such as a specific race or ethnicity [ 20 , 21 , 24 , 33 ] or low income [ 22 , 23 , 27 ]. Studies examined mammography for breast cancer [ 20 , 22 – 24 , 26 , 33 ], Pap smear for cervical cancer [ 21 , 22 ], low-dose computed tomography (CT) for lung cancer [ 28 , 29 ], colorectal cancer screening tests (fecal immunochemical test (FIT) and colonoscopy) [ 30 – 32 ], or skin cancer checks [ 22 ]. On average, studies described 17 CFIR constructs (range: 10–26) (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…A majority of studies described the adaptability of a program by summarizing refinements to the program’s core components to ensure it would resonate with the target population, including cultural relevance [ 21 , 28 , 32 , 33 ] and local knowledge [ 25 , 26 , 30 ]. Some studies discussed adaptability in relation to the ‘adaptable periphery,’ [ 16 ] such as program elements [ 22 , 23 , 27 ] and systems related to the program [ 20 , 24 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

Assessing the use of constructs from the consolidated framework for implementation research in U.S. rural cancer screening promotion programs: a systematic search and scoping review

Moss

Stoltzfus

Popalis

et al. 2023

BMC Health Serv Res

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Background Cancer screening is suboptimal in rural areas, and interventions are needed to improve uptake. The Consolidated Framework for Implementation Research (CFIR) is a widely-used implementation science framework to optimize planning and delivery of evidence-based interventions, which may be particularly useful for screening promotion in rural areas. We examined the discussion of CFIR-defined domains and constructs in programs to improve cancer screening in rural areas. Methods We conducted a systematic search of research databases (e.g., Medline, CINAHL) to identify studies (published through November 2022) of cancer screening promotion programs delivered in rural areas in the United States. We identified 166 records, and 15 studies were included. Next, two reviewers used a standardized abstraction tool to conduct a critical scoping review of CFIR constructs in rural cancer screening promotion programs. Results Each study reported at least some CFIR domains and constructs, but studies varied in how they were reported. Broadly, constructs from the domains of Process, Intervention, and Outer setting were commonly reported, but constructs from the domains of Inner setting and Individuals were less commonly reported. The most common constructs were planning (100% of studies reporting), followed by adaptability, cosmopolitanism, and reflecting and evaluating (86.7% for each). No studies reported tension for change, self-efficacy, or opinion leader. Conclusions Leveraging CFIR in the planning and delivery of cancer screening promotion programs in rural areas can improve program implementation. Additional studies are needed to evaluate the impact of underutilized CFIR domains, i.e., Inner setting and Individuals, on cancer screening programs.

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“…For cancer screening, some advocate imaging or laboratory-based screening over procedure-based screening, when possible, for example in colorectal cancer screening. 23 …”

Section: Discussionmentioning

confidence: 99%

Rural-Urban Differences in Esophagectomy for Cancer

Brungardt

Almoghrabi²,

Bolton‐Moore³

et al. 2021

kjm

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Background: Patients who are socioeconomically disadvantaged or in rural areas may not pursue surgery at high-volume centers, where outcomes are better for some complex procedures. The objective of this study was to determine and compare rural and urban patient differences and outcomes after undergoing esophagectomy for cancer. Study Design: An analysis of the Healthcare Cost and Utilization Project National Inpatient Sample (HCUP NIS) database was performed, capturing adult patients with esophageal cancer who underwent esophagectomy. Patients were stratified into rural or urban groups by the National Center for Health Statistics Urban-Rural Classification Scheme. Demographics, hospital variables, and outcomes were compared. Results: A total of 2,877 patients undergoing esophagectomy for esophageal cancer were captured by the database, with 228 (7.92%) rural and 2,575 (89.50%) urban patients. The rural and urban groups had no difference in age, race, insurance status, and many common comorbidities. Major outcomes of mortality and length of stay were similar for both rural and urban patients (3.95% versus 4.27%, p=0.815) and (15.75±13.22 versus 15.55±14.91 days, p=0.828), respectively. There was a trend for rural patients to be more likely to discharge home (35.96% versus 29.79%, OR 0.667 [95%CI 0.479-0.929]; p=0.0167). Conclusions: This retrospective administrative database study indicates that rural and urban patients receive equivalent postoperative care after undergoing esophagectomy. The findings are reassuring as there does not appear to be a disparity in major outcomes depending on the location of residence, but further studies are necessary to assure equitable treatment for rural patients.

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Colorectal Cancer: A Collaborative Approach to Improve Education and Screening in a Rural Population

Cited by 8 publications

References 12 publications

LncRNA SNHG6 inhibits cell proliferation and metastasis by targeting ETS1 via the PI3K/AKT/mTOR pathway in colorectal cancer

LncRNA SNHG6 inhibits cell proliferation and metastasis by targeting ETS1 via the PI3K/AKT/mTOR pathway in colorectal cancer

Assessing the use of constructs from the consolidated framework for implementation research in U.S. rural cancer screening promotion programs: a systematic search and scoping review

Rural-Urban Differences in Esophagectomy for Cancer

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