ColoPlus, a new product based on bovine colostrum, alleviates HIV-associated diarrhoea

Florén, Claes‐Henrik; Chinenye, S; Elfstrand, Lidia; Hagman, C; Ihse, Ingemar

doi:10.1080/00365520500380817

Cited by 69 publications

(72 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reduction in parasite load was observed in animals given immune colostrum (Fayer et al 1989;Perryman and Bjorneby 1991). In an observational study in Nigeria, HIV-associated diarrhea was alleviated by a 4 week treatment regimen with a commercial bovine colostrum product (Floren et al 2006). Among a 30 patient group with diarrhea, 20 had cryptosporidiosis.…”

Section: Immunotherapeutic Treatment (Colostrum)mentioning

confidence: 99%

Treatment of Cryptosporidiosis

Mead

Arrowood

2013

Cryptosporidium: Parasite and Disease

View full text Add to dashboard Cite

Cryptosporidium species are protozoan parasites that infect the epithelial cells of the gastrointestinal tract. In humans, infections occur primarily in the small intestine resulting in diarrheal illness. Cryptosporidium has a worldwide distribution and is considered an emerging zoonosis. Despite intensive efforts to develop workable experimental models, and the evaluation of nearly 1,000 chemotherapeutic agents, adequate therapies to clear the host of these parasites are still lacking. The reasons for the lack of drug efficacy are probably manifold and may include the unusual location of the parasite in the host cell, distinct structural and biochemical composition of drug targets, or its ability to either block import or rapidly efflux drug molecules. Understanding the basic mechanisms by which drugs are transported to the parasite and identifying unique targets are important steps in developing effective therapeutic agents.

show abstract

Section: Immunotherapeutic Treatment (Colostrum)mentioning

confidence: 99%

Treatment of Cryptosporidiosis

Mead

Arrowood

2013

Cryptosporidium: Parasite and Disease

View full text Add to dashboard Cite

show abstract

“…It was further assumed that the proportion of patients with HIV-associated diarrhea whose diarrhea would subside after receiving colostrum-based supplement was 72% [5,9]. Assuming 20% loss to follow up of the calculated sample size (6.4≈7 patients), the minimum sample size for each arm was 39≈40.…”

Section: Sampling Proceduresmentioning

confidence: 99%

“…An earlier open-labeled observational study from Nigeria indicated clinical improvement of patients with HIV-associated diarrhea on regular supplementation with ColoPlus® [9].…”

Section: Introductionmentioning

confidence: 97%

Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial

Kaducu

Okia

Upenytho

et al. 2011

Indian J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Some authors have reported lactose intolerance, nausea, flatulence, transient diarrhoea and unspecified abdominal discomfort as possible side effects while other studies specifically reported the absence of side effects (83,128,129,165,137,143,189,190). However, further research is required in order to confirm these data, and, more importantly, to evaluate the effects of colostrum when used for a prolonged periods of time and during pregnancy.…”

Section: Side Effects and Contraindicationsmentioning

confidence: 99%