Potential benefits of colostrum in gastrointestinal diseases

Menchetti, Laura; Traina, Giovanna; Tomasello, Giovanni; Casagrande-Proietti, P.; Leonardi, Leonardo; Barbato, Olimpia; Brecchia, Gabriele

doi:10.2741/s467

Cited by 57 publications

(20 citation statements)

References 168 publications

(91 reference statements)

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“…Overall, the current results strongly suggest that the dietary incorporation of bovine colostrum increased potentially beneficial bacteria in both ileum and colon of piglets. Similarly, other studies have shown that the administration of bovine colostrum, because of its antimicrobial and prebiotic properties, may increase the presence of beneficial microbial populations such as LAB genera and reduce bacteria, such as E. coli , Clostridium , and other potential pathogenic species ( Menchetti et al, 2016 ; Poulsen et al, 2017 ). On the other hand, the effects of the CKTL supplementation on the microbial populations of the large intestine are likely due to the prebiotic and antimicrobial properties of its components.…”

Section: Discussionmentioning

confidence: 90%

The combination of nutraceuticals and functional feeds as additives modulates gut microbiota and blood markers associated with immune response and health in weanling piglets

Verso

Talbot

Morissette

et al. 2020

Journal of Animal Science

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This study aimed to evaluate the effects of a combination of feed additives with complementary functional properties on the intestinal microbiota, homocysteine, and vitamins E and B status as well as systemic immune response of weanling piglets. At weaning, 32 litters were assigned to one of the following dietary treatments (DT): 1) conventional diet (CTRL); 2) CTRL diet supplemented with antibiotics (ATB); 3) a cocktail of feed additives containing cranberry extract, encapsulated carvacrol, yeast-derived products, and extra vitamins A, D, E, and B complex (CKTL); or 4) CKTL diet with bovine colostrum in replacement of plasma proteins (CKTL + COL). Within each litter, the piglets with lowest and highest birth weights (LBW and HBW, respectively) and two piglets of medium birth weight (MBW) were identified. The MBW piglets were euthanized at 42 d of age in order to characterize the ileal and colonic microbiota. Blood samples were also collected at weaning and at 42 d of age from LBW and HBW piglets to measure insulin-like growth factor-1 (IGF-1), cysteine, homocysteine, and vitamins E, B6, and B12, and to characterize the leukocyte populations. At 42 d of age, cytokine production by stimulated peripheral blood mononuclear cells was also measured. In a second experiment, piglets were reared under commercial conditions to evaluate the effects of the DT on the growth performance. At the indicator species analysis, the highest indicator value (IV) for Succinivibrio dextrinosolvens was found in the CKTL group, whereas the highest IV for Lactobacillus reuteri and Faecalibacterium prausnitzii was evidenced in the CKTL + COL group (P < 0.05). Compared with the other DT, CTRL piglets had higher concentrations of homocysteine, whereas the CKTL and CKTL + COL supplementations increased the concentrations of vitamins E and B12 (P < 0.05). DT had no effect on IGF-1 concentration and on blood leukocytes populations; however, compared with HBW piglets, LBW animals had lower values of IGF-1, whereas the percentages of γδ T lymphocytes and T helper were decreased and increased, respectively (P < 0.05). CKTL + COL also improved the growth performance of piglets reared under commercial conditions (P < 0.05). This study highlights the impact of birth weight on piglet systemic immune defenses and the potential of weaning diet supplemented with feed additives and bovine colostrum to modulate the homocysteine metabolism and the intestinal microbiota.

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Section: Discussionmentioning

confidence: 90%

The combination of nutraceuticals and functional feeds as additives modulates gut microbiota and blood markers associated with immune response and health in weanling piglets

Verso

Talbot

Morissette

et al. 2020

Journal of Animal Science

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“…BC is composed of >250 functional constituents, including immune-stimulating peptides and antimicrobial agents ( 18 , 19 ). Among BC compounds, major ingredients include macronutrients, immunoglobulins, leukocytes, cytokines, growth factors, lactoferrin (LF), lysozyme (LZ), casein, proline-rich polypeptide, glycomacropeptide (GMP), lactalbumin (LA), and enzymes such as lactoperoxidase (LPO) ( Table 1 ).…”

Section: Constituents Of Bovine Colostrummentioning

confidence: 99%

“…Colostrum thus contributes to the development of the immune system in infants as well as facilitates growth, maturation, and repair processes in distinct tissues. Consequently, BC has significantly higher amounts of growth-promoting factors compared with mature milk ( 16 , 18 , 20 ).…”

Section: Constituents Of Bovine Colostrummentioning

confidence: 99%

Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications

Sienkiewicz

Szymańska

Fichna

2021

Advances in Nutrition

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Inflammatory bowel disease (IBD) is a group of chronic relapsing disorders whose etiology has not been fully explained. Therefore, available therapeutic approaches for IBD patients are still insufficient. Current treatment strategies are targeted to immune system dysfunctions, often associated with alternations in the microbiota, which contribute to the development of chronic intestinal inflammation. Therapeutics include anti-inflammatory drugs such as aminosalicylates and corticosteroids, immunosuppressive agents, antibiotics, and biological agents such as infliximab and vedolizumab. Auxiliary therapies involve a balanced and personalized diet, healthy lifestyle, avoiding stress, as well as dietary supplements. In this review, we discuss the use of bovine colostrum (BC) as a therapeutic agent, including its advantages and contraindications. We summarize our knowledge on well-researched BC constituents and their effects on the gastrointestinal tract as evidenced in in vitro and in vivo studies.

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“…In addition, synergism of the different antimicrobials can be adapted in an attempt to prevent or delay the emergence of resistant populations of the pathogens (Mathur et al, 2017), and our results showed that after fermentation and ultrasonication, BC inhibited MRSA M87fox (established by both methods: inhibition zones and MIC). Bovine colostrum is a safe ingredient since there are no contraindications regarding high dose levels (Menchetti et al, 2016). Reducing the content of pathogenic bacteria is very important for public health because these microorganisms can cause diseases (Özogul and Hamed, 2018).…”

Section: Influence Of Fermentation Ultrasonication and Dehydration mentioning

confidence: 99%

Fermented, ultrasonicated, and dehydrated bovine colostrum: Changes in antimicrobial properties and immunoglobulin content

Bartkienė

Lėlė²,

Šakienė³

et al. 2020

Journal of Dairy Science

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This study evaluated the influence of fermentation with Lactobacillus plantarum LUHS135 and Lactobacillus paracasei LUHS244, ultrasonication, and different methods of dehydration on the content of IgG, IgA, and IgM in bovine colostrum (BC), as well as the antimicrobial activity of the treated and fresh BC samples [fresh = BC; freeze dried = BC lyoph ; vacuum dried (+45°C) = BC vacdried ; BC fermented with LUHS135 = BC LUHS135 ; BC fermented with LUHS244 = BC LUHS244 ; BC fermented with LUHS135 and freeze dried = BC LUHS135lyoph ; BC fermented with LUHS244 and freeze dried = BC LUHS244 lyoph ; BC fermented with LUHS135 and vacuum dried = BC LUHS135 vacdried ; BC fermented with LUHS244 and vacuum dried = BC LUHS244 vacdried ; BC ultrasonicated and freeze dried = BC ultr lyoph ; BC ultrasonicated and vacuum dried = BC ultr vacdried ]. The antimicrobial activity was assessed against Klebsiella pneumoniae, Salmonella enterica, Pseudomonas aeruginosa, Acinetobacter baumanni, Proteus mirabilis, methicillin-resistant Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Bacillus cereus, Streptococcus mutans, Enterobacter cloacae, Citrobacter freundii, Staphylococcus epidermis, Staphylococcus haemolyticus, and Pasteurella multocida using the agar well diffusion method, as well as in liquid medium. In liquid medium analysis showed that the fermented BC samples had the broadest antimicrobial spectrum (of 15 tested pathogenic strains, BC LUHS135 vacdried and BC LUHS135lyoph inhibited 13; BC LUHS244 vacdried inhibited 12; and BC LUHS135 , BC LUHS244 , and BC LUHS244 lyoph inhibited 11). Based on the inhibition zones, BC LUHS135lyoph samples exhibited the broadest inhibition spectrum, inhibiting the growth of 12 of the 15 tested pathogenic strains). According to the lactic acid bacteria strain selected for BC fermentation, different properties of the BC will be obtained. To ensure a broad antimicrobial spectrum and high IgG content, fermentation with LUHS135 can be recommended (IgG concentration in BC LUHS135 was retained), whereas fermentation with LUHS244 will provide a high IgM concentration (IgM concentration increased by 48.8 and 21.6% in BC LUHS244 and BC LUHS244lyoph samples, respectively). However, IgA is very sensitive for fermentation, and further studies are needed to increase IgA stability in BC. Finally, fermented BC can be recommended as a food/beverage ingredient, providing safety, as well as improved functionality through displaying a broad spectrum of antimicrobial activities.

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Potential benefits of colostrum in gastrointestinal diseases

Abstract: 331 ABSTRACTThis paper reviews the composition of colostrum and the potential preventive and therapeutic use of this "first milk" for treating various gastrointestinal disorders

Cited by 57 publications

References 168 publications

The combination of nutraceuticals and functional feeds as additives modulates gut microbiota and blood markers associated with immune response and health in weanling piglets

The combination of nutraceuticals and functional feeds as additives modulates gut microbiota and blood markers associated with immune response and health in weanling piglets

Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications

Fermented, ultrasonicated, and dehydrated bovine colostrum: Changes in antimicrobial properties and immunoglobulin content

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