Colonization by Faecalibacterium Prausnitzii and Maintenance of Clinical Remission in Patients With Ulcerative Colitis

Varela, Encarna; Antolı́n, Maria; Manichanh, Chaysavanh; Gallart, Milagros; Casellas, Montserrat; Torrejón, Antonio; Borruel, Natalia; Casellas, Francesc; Guarner, Francisco

doi:10.1016/s0016-5085(11)60190-x

Cited by 49 publications

(68 citation statements)

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“…dysbiosis) and multiple studies, in IBD patients, have demonstrated dysbiosis. [4][5][6][7][8][9] The dysbiosis found in patients with UC can be described in terms of richness and diversity. Richness delineates the unique number of bacteria present in a microbial community and diversity extends this to account for their relative abundance.…”

Section: Introductionmentioning

confidence: 99%

“…Mouse models revealed that Faecalibacterium prausnitzii has antiinflammatory properties and, in patients with CD, reductions in ileal F. prausnitzii abundance were associated with disease recurrence. 14 In patients with UC, studies have reported either no change 4,10,15 or lower 4,9,[16][17][18] abundance of F. prausnitzii. However, select patients with UC may carry increased amounts of this bacterium in the colonic mucosa.…”

Section: Introductionmentioning

confidence: 99%

“…19 From stool samples, reductions in F. prausnitzii abundance were associated with an increased number of disease flares, a shorter time in remission, and a greater disease extent (pancolitis versus proctitis) in adult UC patients. 9 The significance of prior studies, however, may be limited by other confounding factors. The majority of prior work in UC included patients on treatment, 4,5,11 which can independently influence microbiome composition.…”

Section: Introductionmentioning

confidence: 99%

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Composition and function of the pediatric colonic mucosal microbiome in untreated patients with ulcerative colitis

et al. 2016

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Inflammatory bowel diseases (IBD) are chronic intestinal inflammatory disorders characterized by a complex disruption of the physiologic interaction between the host immune system and intestinal microbes precipitated by environmental factors. Numerous observations indicate the altered composition and function of the intestinal microbiome of patients with ulcerative colitis (UC), a subtype of IBD. The accuracy of these results may be limited by confounding factors, such as concurrent medication use. To address these limitations, we examined the colonic mucosal microbiome of pediatric patients with UC prior to initiating treatment. Based on bacterial 16S rRNA gene sequencing, we identified a significant decrease in the phylum Verrucomicrobia in patients with UC. At the genus level, we observed a significant decrease in the short chain fatty acid producer Roseburia. Despite these compositional changes, we did not identify inferred gene content differences between the UC and control groups. To determine if microbial taxa may be associated with clinical outcomes, we retrospectively assessed the clinical course of the UC patients. Despite similar metrics of OTU richness and diversity, multiple OTU differences were observed between patients who responded to therapy and those who did not. Our observations regarding the mucosal microbiome and the associations with differential clinical outcomes support the contributions of gut microbes to disease onset and modulation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Composition and function of the pediatric colonic mucosal microbiome in untreated patients with ulcerative colitis

et al. 2016

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“…There is contrasting evidence when comparing microbial alterations between IBD patients and their relatives. One study found no consistency between microbial changes in UC patients when compared to their unaffected twin, whereas another reported decreases in Faecalibacterium prausnitzii in both UC patients and their first degree relatives [56,57]. Since inter-individual difference are much greater than inter-disease differences, it is difficult to establish common microbial alterations that may be used to characterize a particular disease [54,58].…”

Section: Genetic and Microbial Interactions In Inflammatory Bowel Dismentioning

confidence: 99%

Nature vs. Nurture: The Gut Microbiome and Genetics in the Development of Gastrointestinal Disease

Ec¹,

Da²

2016

J Hepatol Gastroint Dis

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“…E. coli is also overrepresented among active fecal bacteria of UC patients, and is suggested to have a role in the development of colitis [77]. The number of Faecalibacterium prausnitzii, associated with mucosal protection, was also reduced in fecal samples of UC patients recovering from a relapse [79]. Similarly, in an in vitro dynamic gut model called M-SHIME, butyrate producing bacteria were less abundant and butyrate production was reduced among luminal microbiota from UC patients, which may cause energy deficiency in colonocytes [80].…”

Section: Dysbiosis In Ucmentioning

confidence: 99%

Pathogenesis of Ulcerative Colitis and Crohn’s Disease: Similarities, Differences and a Lot of Things We Do Not Know Yet

Molnár¹

2014

J Clin Cell Immunol

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The pathogenesis of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD) is complex, and our knowledge on the topic is constantly growing. The two disorders are distinct, yet overlap in their clinical manifestations and underlying causes. This review aims to provide a broad overview of the numerous pathogenetic factors that can lead to the development of IBD, focusing on novel findings and on the differences between UC and CD. Recent advances in genetics have identified new components in the pathogenesis, as an example, the importance of Th17 lymphocytes and the IL-17/IL-23 pathway have been highlighted in both diseases, apart from the previously known Th1-Th2 driven processes. Genetic background of increased permeability has been explored in UC, and the role of defective autophagy was recently described in CD. Genetic alterations can lead to an exaggerated immune response to the resident microbial flora. This microflora is altered in IBD patients, probably due to their reduced ability to stabilize its bacterial components and due to different environmental factors. An exhaustive exploration of environmental factors is particularly important, as they can be influential in many cases. The impact of smoking is the most established environmental factor, having deleterious effects in CD and protective in UC. Recent opinions on other factors, such as early appendectomy, diet, reduced vitamin D levels, the use of specific medications, breastfeeding, personal hygiene and psychological factors are also discussed. Epigenetics, a new field of research, links environmental factors to genetics. Understanding these factors is of great significance as changing lifestyles and improving life circumstances have started to increase the prevalence of IBD also in developing countries.

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Colonization by Faecalibacterium Prausnitzii and Maintenance of Clinical Remission in Patients With Ulcerative Colitis

Cited by 49 publications

References 0 publications

Composition and function of the pediatric colonic mucosal microbiome in untreated patients with ulcerative colitis

Composition and function of the pediatric colonic mucosal microbiome in untreated patients with ulcerative colitis

Nature vs. Nurture: The Gut Microbiome and Genetics in the Development of Gastrointestinal Disease

Pathogenesis of Ulcerative Colitis and Crohn’s Disease: Similarities, Differences and a Lot of Things We Do Not Know Yet

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