Colonic perforation by amyloidosis

Sánchez, José Antonio González; Molinero, R. Martin; Sayans, J. Domínguez; Sanchez, Fabian

doi:10.1007/bf02563700

Cited by 20 publications

(5 citation statements)

References 16 publications

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“…There is no knowledge about endoscopic and histopathologic evaluation of gastrointestinal mucosa in children with FMF in the literature. Endoscopic findings and mucosal involvement of the gastrointestinal tract without amyloidosis was established as a main characteristic of the disease in our patients by endoscopic procedures (6)(7)(8).…”

Section: Discussionmentioning

confidence: 95%

Gastrointestinal Mucosal Involvement Without Amyloidosis in Children With Familial Mediterranean Fever

Gürkan

Dalgıç²

2013

J. pediatr. gastroenterol. nutr.

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Section: Discussionmentioning

confidence: 95%

Gastrointestinal Mucosal Involvement Without Amyloidosis in Children With Familial Mediterranean Fever

Gürkan

Dalgıç²

2013

J. pediatr. gastroenterol. nutr.

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“…Survival is much worse which is about 4-6 months in cases of AL synchronously with Multiple Myeloma. [8][9][10] The average survival duration is 1 year after the histological diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Primary Amyloidosis Presenting with Massive Proteinuria and Localized Gastrointestinal Involvement

Cengiz¹,

Özden²,

Yavuzer³

et al. 2015

Turkiye Klinikleri J Case Rep

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FIGURE 3:On the left, slightly bulging and fluffy appearance of ampulla Vateri is seen with ERCP, and on the right, irregularity of the papilla is seen with EUS. FIGURE 4:Congo-Red positive amyloid deposition in the lamina propria of a small intestinal mucosal biopsy (Congo-Redx200). FIGURE 5:Negative immune reaction in lamina propria with immunohistochemical amyloid marker and non-specific moderate epithelial staining at some of the tips of intestinal villi (Amiloid Ax100).

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“…The clinical manifestations of amyloid deposit into the colon may mimic other diseases including inflammatory bowel disease, malignancy, ischemic colitis, and collagenous colitis [44][45][46][47]. Complications include colonic dilatation, pseudo-obstruction, stricture formation, rectal bleeding, submucosal hemorrhage, volvulus, infarction, and perforation [41,[48][49][50][51][52].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Clinical management of gastrointestinal amyloidosis

Isomoto¹,

Kamo²,

Chen³

et al. 2012

OJGas

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Amyloidosis is characterized by extracellular deposition of abnormal protein, consisting of primary, secondary, hemodialysis-related, hereditary, senile and localized type. Primary amyloidosis is associated with monoclonal light chains. Secondary amyloidosis is associated with inflammatory, infectious, and neoplastic diseases. Amyloid deposition in the gastrointestinal tract can manifest the symptoms including diarrhea, steatorrhea, or constipation. For diagnosis, one should obtain an immunofixation of serum or urine as well as biopsy sampling of gastrointestinal mucosa stained specifically. While most gastrointestinal complications are managed symptomatically, treatment depends upon the type of amyloidosis. Causal therapy is reserved for a select few from various subtypes of this disorder

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Colonic perforation by amyloidosis

Abstract: One patient with a colonic perforation associated with secondary amyloidosis and ankylosing rheumatoid spondylitis was treated successfully. To our knowledge, this is the first case described of colonic perforation in amyloidosis.

Cited by 20 publications

References 16 publications

Gastrointestinal Mucosal Involvement Without Amyloidosis in Children With Familial Mediterranean Fever

Gastrointestinal Mucosal Involvement Without Amyloidosis in Children With Familial Mediterranean Fever

A Case of Primary Amyloidosis Presenting with Massive Proteinuria and Localized Gastrointestinal Involvement

Clinical management of gastrointestinal amyloidosis

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