Gastrointestinal Mucosal Involvement Without Amyloidosis in Children With Familial Mediterranean Fever

Abstract

In this report, we described 11 patients who presented with gastrointestinal symptoms and eventually diagnosed as having FMF. Gastrointestinal mucosal involvement without amyloidosis is documented by endoscopic and histopathologic investigations in these patients. We concluded that mucosal involvement of the gastrointestinal tract may be attack-related manifestations in these patients.

Recurrent Abdominal Pain Accompanied by Small Intestinal Lesions

“…2 Although only a few endoscopic findings have been reported, colonoscopy revealed hyperemia, fragility, and patchy ulcerations with white exudate in the large intestinal mucosa. 3 To our knowledge, this case report is the first study to describe observations for the small intestine, which, because they are similar to the findings for the large intestine described previously, indicate that CE and DBE are useful in the diagnosis of FMF.…”

Small bowel mucosal damage in familial Mediterranean fever: results of capsule endoscopy screening

“…The only endoscopic investigation aiming to detect FMF-related gastrointestinal lesions was reported in a small pediatric cohort by Gurkan et al [9]. They showed colonic inflammation and multiple gastric aphthous ulcerations without amyloid infiltration by gastroscopy and colonoscopy in 11 out of 36 pediatric FMF patients with gastrointestinal symptoms, and they concluded that mucosal involvement of the gastrointestinal tract may be attack-related manifestations in these patients.…”

MEFV gene testing may guide physicians for early diagnosis of familial Mediterranean fever

“…But these procedures may only help clinical assessments during diagnosis of FMF . Furthermore, FMF patients had nonspecific findings in screening tests . However, up to now, these have not been given as much weight as clinical features.…”