Colonic Involvement in Celiac Disease and Possible Implications of the Sigmoid Mucosa Organ Culture in its Diagnosis

Picarelli, Antonio; Tola, Marco Di; Borghini, Raffaele; Isonne, Claudia; Saponara, Annarita; Marino, Mariacatia; Casale, Rossella; Tiberti, Antonio; Pica, Roberta; Donato, Giuseppe; Frieri, Giuseppe; Corazziari, Enrico

doi:10.1007/s10875-013-9920-3

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…CD diagnosis frequently occurs in individuals with a familial history of the condition or other autoimmune disorders. Typically, the diagnostic process involves a combination of serological testing, genetic testing, and small intestine biopsy [ 4 ]. Genetically, most patients with CD express HLA-DQ2 or HLA-DQ8 haplotypes, although these are also found in approximately 30–40% of the general population [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease

Lucchese

Stasio

Stefano

et al. 2023

JCM

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Background: Celiac disease (CD) is a chronic immune-mediated gluten-sensitive enteropathy, affecting about 1% of the population. The most common symptoms include diarrhea, abdominal pain, weight loss, and malabsorption. Extra-intestinal symptoms include oral manifestations. This systematic review aims to catalog and characterize oral manifestations in patients with CD. Methods: a systematic literature review among different search engines using PICOS criteria has been performed. The studies included used the following criteria: tissues and anatomical structures of the oral cavity in humans, published in English and available in full text. Review articles and papers published before 1990 were excluded. Results: 209 articles were identified in the initial search. In the end, 33 articles met the selection criteria. The information extracted from the articles was classified based on the type of oral manifestation. Recurrent aphthous stomatitis (34.6%), atrophic glossitis and geographic tongue (15.26%), enamel defects (42.47%), delayed dental eruption (47.34%), xerostomia (38.05%), glossodynia (14.38%), and other manifestations including cheilitis, fissured tongue, periodontal diseases, and oral lichen planus were found in the celiac subjects of the studies analyzed. The quality of articles on the topic should be improved; however, oral manifestations in CD patients are widely described in the literature and could help diagnose celiac disease.

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Section: Introductionmentioning

confidence: 99%

Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease

Lucchese

Stasio

Stefano

et al. 2023

JCM

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“…Positive serological IgA and IgG anti-endomysium (EMA), anti-transglutaminase (anti-Ttg), and anti-deamidated gliadin peptide (AGA DGP) antibody results can support the diagnosis of CD (2). Recent literature has also shown the precious role of duodenal biopsy organ culture system when villous height/crypt depth ratio, intraepithelial lymphocyte count, or serum antibody tests are not clearly diagnostic: EMA-and anti-tTGpositive results in culture biopsy supernatants of the second part of the duodenum may be helpful in making a CD diagnosis (3)(4)(5). CD recedes after a gluten-free diet is started.…”

Section: Introductionmentioning

confidence: 99%

Mutatis mutandis: Are we diagnosing too many people with non-celiac gluten sensitivity? Multiple case report

Borghini

Donato²,

Tola³

et al. 2014

Turk J Gastroenterol

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We report three patients presenting with gluten-related signs and symptoms. Since villous height/crypt depth ratio, intraepithelial lymphocyte count, and serum antibody tests were not diagnostic for celiac disease (CD), a diagnosis of non-celiac gluten sensitivity (NCGS) was suggested. On the other hand, antibodies suggestive for CD surprisingly showed positive results in the duodenal biopsy organ culture of all three cases. The reported cases suggest the precious potential role that organ culture systems may play in differentiating CD from NCGS. This method should be recommended when gluten-related disorders are suspected in order to reduce the inappropriate diagnosis of NCGS.

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Culture of gastric biopsies in celiac disease and its relationship with gastritis and Helicobacter pylori infection

Borghini

Donato

Marino

et al. 2018

Digestive and Liver Disease

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Colonic Involvement in Celiac Disease and Possible Implications of the Sigmoid Mucosa Organ Culture in its Diagnosis

Abstract: Data confirm that the gluten-dependent immunological activation affects more intestinal tracts with different degrees of involvement, suggesting that the organ culture of colonic biopsies could represent a new tool to opportunistically detect CD.

Cited by 8 publications

References 29 publications

Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease

Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease

Mutatis mutandis: Are we diagnosing too many people with non-celiac gluten sensitivity? Multiple case report

Culture of gastric biopsies in celiac disease and its relationship with gastritis and Helicobacter pylori infection

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