Colonic Ewing Sarcoma/PNET associated with liver metastases: A systematic review and case report

Parcesepe, Pietro; Giordano, Guido; Zanella, Caterina; Giuliani, Jacopo; Greco, Filippo; Bonetti, Andrea; Pancione, Massimo; Manfrin, Erminia; Molinari, Enrico; Latiano, Tiziana Pia; D’Andrea, Mario; Fassan, Matteo; Olivieri, Nunzio; Remo, Andrea

doi:10.1016/j.prp.2018.11.021

Cited by 10 publications

(15 citation statements)

References 21 publications

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“…Merely 30% of ES patients with metastasis survive [13]. e lung is one of the most common sites suffering from Ewing sarcoma metastasis while the previous study also showed that colonic Ewing sarcoma could cause liver metastasis [14].…”

Section: Discussionmentioning

confidence: 95%

“…Merely 30% of ES patients with metastasis survive [ 13 ]. The lung is one of the most common sites suffering from Ewing sarcoma metastasis while the previous study also showed that colonic Ewing sarcoma could cause liver metastasis [ 14 ]. Early diagnosis and treatment can remarkably improve the clinical prognosis of ES, which justifies the need to seek effective biomarkers for the early diagnosis and treatment of ES.…”

Section: Discussionmentioning

confidence: 99%

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Prognosis Implication of a Novel Metabolism-Related Gene Signature in Ewing Sarcoma

Chen

Yang

et al. 2021

Journal of Oncology

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Ewing sarcoma (ES) is one of the most common bone cancers in adolescents and children. Growing evidence supports the view that metabolism pathways play critical roles in numerous cancers (He et al. (2020)). However, the correlation between metabolism-associated genes (MTGs) and Ewing sarcoma has not been investigated systematically. Here, based on the univariate Cox regression analysis, we get survival genes from differentially expressed genes (DEGs) from Gene Expression Omnibus (GEO) cohort. Multivariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) regression analysis were employed to establish the MTG signature. Comprehensive survival analyses including receiver operating characteristic (ROC) curves and Kaplan–Meier analysis were applied to estimate the independent prognostic value of the signature. The ICGC cohort served as the validation cohort. A nomogram was constructed based on the risk score of the MTG signature and other independent clinical variables. The CIBERSORT algorithm was applied to estimate immune infiltration. In addition, we explored the correlation between MTG signature and immune checkpoints. Collectively, this work presents a novel MTG signature for prognostic prediction of Ewing sarcoma. It also suggests six genes that are potential prognostic indicators and therapeutic targets for ES.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Prognosis Implication of a Novel Metabolism-Related Gene Signature in Ewing Sarcoma

Chen

Yang

et al. 2021

Journal of Oncology

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“…Before the diagnostic examination, the patient signed her informal consent for the 18 F -FDG PET/CT study.…”

Section: Case Reportmentioning

confidence: 99%

“…These observations can be the platform for further investigation of new therapeutic regimens. Keywords: Ewing sarcoma of the lung; 18…”

Section: Summary Introductionmentioning

confidence: 99%

18F-fluorodeoxyglucose positron emission tomography / computed tomography in primary Ewing sarcoma of the lung

Zivgarevic¹,

Zunic²

2022

Srp Arh Celok Lek

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Introduction. Ewing sarcoma is rare in medical practice, and evaluating positron emission tomography/computed tomography imaging of soft tissue Ewing sarcoma is a challenge. Primary Ewing sarcoma of the lung is an infrequent diagnosis. Case outline. A 22-year-old female patient was sent for PET/CT examination to the Center for Nuclear Medicine with Positron Emission Tomography, of the University Medical Center of Serbia, with a referral diagnosis of primary Ewing sarcoma of the right lung. In parallel to tumor visualization, the positron emission tomography/computed tomography imaging showed a radiological entity named ?Kissing sign,? due to an enlarged beaver tail liver. Conclusion. According to the concept of functional mimicry and tissue specificity of molecular markers, a better understanding of the molecular mechanisms of soft tissue Ewing sarcoma is the challenge. These observations can be the platform for further investigation of new therapeutic regimens.

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“…A primary primitive neuroectodermal tumor (PNET) is a rare and malignant neoplasm that belongs to the Ewing family of tumors. These tumors have a predilection for the central nervous system [ 1 ] of children and young adults; however, they may occasionally be observed in other sites such as the chest wall, [ 2 ] head and neck, [ 3 ] kidneys, [ 4 ] adrenal glands, [ 5 ] female genital tract, [ 6 ] extremities, and scrotal sac. [ 7 ] A PNET occurring in the bladder is very rare; it develops more commonly in children and adolescents than in adults.…”

Section: Introductionmentioning

confidence: 99%

Primary adult primitive neuroectodermal tumor of the bladder

Liu¹,

Zhang

2020

Medicine

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Rationale: A primary primitive neuroectodermal tumor (PNET) is a rare and highly malignant tumor that often occurs in the central nervous system of children and young adults. This tumor is rarely observed in the bladder. Patient concerns: In this paper, we describe the case of a 64-year-old man with a PNET of the bladder. He experienced dull pain in the lower left abdomen for 5 months (without any obvious inducement), which gradually became aggravated and intolerable. Diagnoses: Partial cystectomy was performed, and a PNET of the bladder, which is extremely rare, was confirmed. Interventions: Following cystectomy, the patient's general postoperative state was poor and he could not tolerate chemotherapy. Thus, he was subjected to pelvic radiotherapy for 2 weeks. Outcomes: His physical condition did not improve significantly after radiotherapy; however, we still plan to continue it. If the patient's physical condition improves, chemotherapy will be considered. Lessons: Most cases of PNETs are intravesical or at least mainly endophytic. However, in this case, the mucosal layer was barely involved, and the tumor mainly grew out of the bladder, which is very rare. The present case provides reference for the diagnosis of PNET.

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Colonic Ewing Sarcoma/PNET associated with liver metastases: A systematic review and case report

Cited by 10 publications

References 21 publications

Prognosis Implication of a Novel Metabolism-Related Gene Signature in Ewing Sarcoma

Prognosis Implication of a Novel Metabolism-Related Gene Signature in Ewing Sarcoma

18F-fluorodeoxyglucose positron emission tomography / computed tomography in primary Ewing sarcoma of the lung

Primary adult primitive neuroectodermal tumor of the bladder

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