Primary adult primitive neuroectodermal tumor of the bladder

Abstract

Rationale: A primary primitive neuroectodermal tumor (PNET) is a rare and highly malignant tumor that often occurs in the central nervous system of children and young adults. This tumor is rarely observed in the bladder. Patient concerns: In this paper, we describe the case of a 64-year-old man with a PNET of the bladder. He experienced dull pain in the lower left abdomen for 5 months (without any obvious inducement), which gradually became aggravated and intolerable. Diagnoses: Partial cystectomy was performed, and a PNET of the bladder, which is extremely rare, was confirmed. Interventions: Following cystectomy, the patient's general postoperative state was poor and he could not tolerate chemotherapy. Thus, he was subjected to pelvic radiotherapy for 2 weeks. Outcomes: His physical condition did not improve significantly after radiotherapy; however, we still plan to continue it. If the patient's physical condition improves, chemotherapy will be considered. Lessons: Most cases of PNETs are intravesical or at least mainly endophytic. However, in this case, the mucosal layer was barely involved, and the tumor mainly grew out of the bladder, which is very rare. The present case provides reference for the diagnosis of PNET.

A rare radiotherapy-sensitive primitive neuroectodermal tumor with APC gene amplification in an adult: a case report and literature review

“…It is a high-grade malignant tumor with early metastasis and an extremely poor prognosis. PNET can reportedly develop anywhere in the body, including the orbit, nasal cavity, mediastinum, stomach, bone, uterus, kidney, neck, chest, pancreas, gingiva, paraspinal region, ovaries, breast, testes, and thymus; 1 – 4 , 6 – 9 however, it is rarely found in the lung. Only 15 related cases were retrieved from the literature from 2012 to 2022 ( Table 1 ).…”

Ewing’s sarcoma/primitive neuroectodermal tumor (ES/PNET) of the bladder in an adolescent: a case description

“…These tumors frequently occur in the extremities and retroperitoneum (5,6), and are seldom in the internal organs. ES/PNET of the bladder is rare, with only a few reports available at present (7,8). We report a case of primary ES of the bladder that occurred in a 19-year-old female.…”

Tumor neuroectodérmico primitivo primario de ovario

“…El tumor neuroectodérmico primitivo primario (TNPP) es un sarcoma de tejido blando de células redondas pequeñas y comparte muchas características morfológicas con el sarcoma de Ewing, sobre la base de la translocación cromosómica compartida en EWSR1 (región 1 del punto de rotura del sarcoma de Ewing) (2) . Aunque suele producirse en los tejidos blandos de niños y adultos jóvenes, se ha notificado casos primarios en sitios viscerales como riñón, ovario, vagina, testículo, útero, cuello uterino, vejiga urinaria, glándula parótida, corazón, pulmón, recto, páncreas y vesícula biliar.…”