Colon volvulus in rhesus macaques (<i>Macaca mulatta</i>) at the Oregon National Primate Research Center—Retrospective analysis

Johnson, Amanda L.; Bronson, Steven M.; Prongay, Kamm; Norris, Reed; Lewis, Anne D.

doi:10.1111/jmp.12516

Cited by 2 publications

(2 citation statements)

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“…Colonic torsions are infrequently identified in juvenile and adult macaques. 155,156 Risk factors include previous abdominal surgery, abdominal adhesions, recurrent or persistent diarrhea, idiopathic megacolon, semipurified (atherogenic) diets, and sedentary existence. Animals usually present with marked abdominal distention and shock.…”

Section: Noninfectious Causes Of Gastrointestinal Tract Lesions In Ma...mentioning

confidence: 99%

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

et al. 2022

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Rhesus and cynomolgus macaques are the most frequently used nonhuman primate (NHP) species for biomedical research and toxicology studies of novel therapeutics. In recent years, there has been a shortage of laboratory macaques due to a variety of competing factors. This was most recently exacerbated by the surge in NHP research required to address the severe acute respiratory syndrome (SARS)-coronavirus 2 pandemic. Continued support of these important studies has required the use of more varied cohorts of macaques, including animals with different origins, increased exposure to naturally occurring pathogens, and a wider age range. Diarrhea and diseases of the gastrointestinal tract are the most frequently occurring spontaneous findings in macaques of all origins and ages. The purpose of this review is to alert pathologists and scientists involved in NHP research to these findings and their impact on animal health and study endpoints, which may otherwise confound the interpretation of data generated using macaques.

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Section: Noninfectious Causes Of Gastrointestinal Tract Lesions In Ma...mentioning

confidence: 99%

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

et al. 2022

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“…In rhesus, colonic volvulus may occur secondary to abdominal surgery that forms adhesions, diarrhea, megacolon, sedentary lifestyle, or atherogenic diets. 28 The clinical signs are often vague and include abdominal distension and shock, which may not be detected during routine evaluation. 28 In this case, the torsion is likely secondary to previous abdominal surgery to obtain intestinal biopsies because the small intestine was twisted around adhesions that formed at the surgical site.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal tract pathology of the owl monkey (Aotus spp.)

Hensel,

Rodrigues-Hoffmann,

Dray

et al. 2023

Vet Pathol

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Owl monkeys are small nocturnal new world primates in the genus Aotus that are most used in biomedical research for malaria. Cardiomyopathy and nephropathy are well-described common diseases contributing to their morbidity and mortality; less is known about lesions affecting the gastrointestinal tract. Records from a 14-year period (2008-2022) at the Keeling Center for Comparative Medicine and Research were queried to identify instances of spontaneous gastrointestinal disease that directly contributed to the cause of death from the 235 adult owl monkeys submitted for necropsy. Of the 235, 10.6% (25/235) had gastrointestinal disease listed as a significant factor that contributed to morbidity and mortality. Diagnoses included candidiasis (3/25), gastric bloat (4/25), and intestinal incarceration and ischemia secondary (11/25), which included intussusception (4/25), mesenteric rent (3/25), strangulating lipoma (2/25), intestinal torsion (1/25), and an inguinal hernia (1/25). Intestinal adenocarcinomas affecting the jejunum (4/25) were the most common neoplasia diagnosis. Oral squamous cell carcinoma (1/25) and intestinal lymphoma (2/25) were also diagnosed. This report provides evidence of spontaneous lesions in the species that contribute to morbidity and mortality.

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Colon volvulus in rhesus macaques (Macaca mulatta) at the Oregon National Primate Research Center—Retrospective analysis

Cited by 2 publications

References 2 publications

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

Gastrointestinal tract pathology of the owl monkey (Aotus spp.)

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