Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells

Prakash, Satya; Urbanska, Aleksandra M.

doi:10.2147/btt.s2372

Cited by 9 publications

(7 citation statements)

References 228 publications

(192 reference statements)

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“…Colitis was induced by the method of [31] with slight modifications. Except the animals in normal control group, all the other animals were supplemented with 3% DSS in drinking water throughout the experimental period.…”

Section: Induction Of Colitis and Treatmentmentioning

confidence: 99%

Isolation and Characterization of Putative Probiotic Bacterial Strain, Bacillus amyloliquefaciens, from North East Himalayan Soil Based on In Vitro and In Vivo Functional Properties

Ibrahim¹,

Babu²,

Pandikumar³

et al. 2011

Probiotics & Antimicro. Prot.

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This study is aimed to isolate some novel probiotics from the soils of North East Himalayas. Eleven Gram positive isolates were obtained in MRS with Oxgall media from soil samples. Four of the isolates withstood the in vitro gastric juice pH 3.0 and 0.45% bile salt tolerance screening. Among these, PBT 3 showed high cell surface hydrophobicity and adhered to the Caco-2 cells. 16s rDNA gene sequences of this probiotic strains were identified as Bacillus amyloliquefaciens (accession no: JF836079). In in vivo bioefficacy evaluation by DSS-induced colitis animals, B. amyloliquefaciens significantly ameliorated the loss in body weight. Further, the treatment altered the levels of myeloperoxidase, lipoperoxides, and mucous content in the colon tissues compared with normal colon. It reduced the protein and mRNA levels of pro-inflammatory cytokines such as TNF-α and IL-1β. These biochemical findings were supported by histopathological evidences. Our study reports the use of B. amyloliquefaciens isolated from Himalayan soil as probiotic and its beneficial effect on IBD for the first time and suggests that this could be used as potential probiotics in functional foods or as a curative agent.

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Section: Induction Of Colitis and Treatmentmentioning

confidence: 99%

Isolation and Characterization of Putative Probiotic Bacterial Strain, Bacillus amyloliquefaciens, from North East Himalayan Soil Based on In Vitro and In Vivo Functional Properties

Ibrahim¹,

Babu²,

Pandikumar³

et al. 2011

Probiotics & Antimicro. Prot.

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“…With regard to CRC, numerous clinical trials have shown the potential of probiotics as adjuvants, reducing the side effects associated with chemotherapy and surgeries in CRC-patients [85,86]. The delivery of live biotherapeutic cells for the treatment of GI diseases is well known and the immunomodulatory and anti-inflammatory properties of probiotics on colon cancer is well understood [87]; however, few studies exist that demonstrate the potential of probiotics to eradicate CRC-associated bacteria from the gut microbiome, consequently reducing the risk of disease development.…”

Section: Potential Use Of Biotherapeutic Bacteria To Target Colorectamentioning

confidence: 99%

Potential Use of Biotherapeutic Bacteria to Target Colorectal Cancer-Associated Taxa

Lawrence

Begley

Cotter

et al. 2020

IJMS

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The role of the gut microbiome in human health and disease is the focus of much attention. It has been widely agreed upon that our gut bacteria play a role in host immunity, nutrient absorption, digestion, metabolism, and other key drivers of health. Furthermore, certain microbial signatures and specific taxa have also been associated with the development of diseases, such as obesity; inflammatory bowel disease; and, indeed, colorectal cancer (CRC), which is the focus of this review. By extension, such taxa represent potential therapeutic targets. In particular, the emerging human pathogen Fusobacterium nucleatum represents an important agent in CRC development and its control within the gastrointestinal tract is desirable. This paper reviews the principal bacterial pathogens that have been associated with CRC to date and discusses the in vitro and human studies that have shown the potential use of biotherapeutic strains as a means of targeting CRC-associated bacteria.

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“…The enzymes they produce areglucuronidase, -galactosidase, nitroreductase, azoreductase, etc. Number of mucosal bacteria increases progressively in the state of inflammation, with concentrations relatively higher in patients with active disease (Prakash & Urbanska, 2008).…”

Section: Colon As a Target For Drug And Probiotic Cell Delivery In Comentioning

confidence: 99%

Drug and Cell Delivery Systems in the Treatment of Colitis

Mladenovska¹

2012

Colitis

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Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells

Cited by 9 publications

References 228 publications

Isolation and Characterization of Putative Probiotic Bacterial Strain, Bacillus amyloliquefaciens, from North East Himalayan Soil Based on In Vitro and In Vivo Functional Properties

Isolation and Characterization of Putative Probiotic Bacterial Strain, Bacillus amyloliquefaciens, from North East Himalayan Soil Based on In Vitro and In Vivo Functional Properties

Potential Use of Biotherapeutic Bacteria to Target Colorectal Cancer-Associated Taxa

Drug and Cell Delivery Systems in the Treatment of Colitis

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