Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil

Abid, Mehwish; Naveed, Muhammad; Azeem, Iqra; Faisal, Amir; Nazar, Muhammad Faizan; Yameen, Basit

doi:10.1016/j.ijpharm.2020.119605

Cited by 44 publications

(26 citation statements)

References 69 publications

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“…87 Yameen's group developed novel enzyme-responsive DEX based oligoester crosslinked NPs for the controlled release of an anticancer drug, 5-fluorouracil (5-FU). 217 The results obtained from their study showed that 5-FU was effectively encapsulated in the DEXNPs (Fig. 10), and the synthesised DEXNPs maintained their stability at pH conditions representative of specific in vivo environments (e.g.…”

Section: Polysaccharide Nanoparticles In Nanomedicinementioning

confidence: 96%

Polysaccharide nanoparticles: from fabrication to applications

2021

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Section: Polysaccharide Nanoparticles In Nanomedicinementioning

confidence: 96%

Polysaccharide nanoparticles: from fabrication to applications

2021

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“…which can be simply modified by an organic reaction. Due to these characteristics, polysaccharides are widely used as a platform in applications such as green electronics, nanoparticles, and hydrogels through chemical modification [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Succinoglycans: Structure, Physical Properties, and Applications

Jeong

Kim

et al. 2022

Polymers

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Succinoglycan is a type of bacterial anionic exopolysaccharide produced from Rhizobium, Agrobacterium, and other soil bacteria. The exact structure of succinoglycan depends in part on the type of bacterial strain, and the final production yield also depends on the medium composition, culture conditions, and genotype of each strain. Various bacterial polysaccharides, such as cellulose, xanthan, gellan, and pullulan, that can be mass-produced for biotechnology are being actively studied. However, in the case of succinoglycan, a bacterial polysaccharide, relatively few reports on production strains or chemical and structural characteristics have been published. Physical properties of succinoglycan, a non-Newtonian and shear thinning fluid, have been reported according to the ratio of substituents (pyruvyl, succinyl, acetyl group), molecular weight (Mw), and measurement conditions (concentration, temperature, pH, metal ion, etc.). Due to its unique rheological properties, succinoglycan has been mainly used as a thickener and emulsifier in the cosmetic and food industries. However, in recent reports, succinoglycan and its derivatives have been used as functional biomaterials, e.g., in stimuli-responsive drug delivery systems, therapeutics, and cell culture scaffolds. This suggests a new and expanded application of succinoglycan as promising biomaterials in biomedical fields, such as tissue engineering, regenerative medicine, and pharmaceuticals using drug delivery.

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“…Controlled drug release of 5-FU has been demonstrated by loading it onto colonic enzyme-responsive dextran-based oligoester NPs. The enzyme dextranase triggered the release of the encapsulated drug, and the actions of this enzyme were likely the cause of the increased bioavailability and elevated toxicity of the nano formula for the treatment of colorectal cancer ( Abid, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Nanocarriers for anticancer drugs: Challenges and perspectives

Alqosaibi

2022

Saudi Journal of Biological Sciences

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Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil

Cited by 44 publications

References 69 publications

Polysaccharide nanoparticles: from fabrication to applications

Polysaccharide nanoparticles: from fabrication to applications

Bacterial Succinoglycans: Structure, Physical Properties, and Applications

Nanocarriers for anticancer drugs: Challenges and perspectives

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