Colon capsule endoscopy as possible filter test for colonoscopy selection in a screening population with positive fecal immunology

Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy

“…Furthermore, sensitivity and specificity for examinees with at least one polyp or tumor with maximum size 6 mm or larger or 10 mm or larger using regimens with and without castor oil were not different. Overall adequate colorectal cleansing levels at CCE in previous studies have been 52%–94% . Although castor oil did not significantly interfere with colorectal cleansing levels in spite of reducing fluid and lavage loading, the regimen with castor oil showed an average cleansing level.…”

“…Capsule excretion rates or complete colorectal observational rates have varied among studies. Using the European traditional bowel preparation of a large-volume PEG (4.5-6 L) followed by oral sodium phosphate booster (1.5-2.0 L) and with prokinetics such as domperidone, capsule excretion rates within approximately 10 h or battery life has been 70%-88%, 9,[11][12][13][14][15][16][17][18][19] except for studies by van Gossum (93%) 20 and by Sacher-Huvelin (95%). 21 If the data of all listed studies above are taken together, the capsule excretion rate would be 88% (1243/1407).…”

Back‐to‐back colon capsule endoscopy and optical colonoscopy in colorectal cancer screening individuals

“…Colon capsule endoscopy (CCE) is a relatively new technique that has been proposed as a filter for referral to OC in CRC screening programmes, and was found to reduce the need for colonoscopy by 71% in a study of 63 individuals [3]. The second generation CCE has a reported sensitivity and specificity for detecting polyps > 9 mm of 87% and 95%, respectively [4].…”

“…The second generation CCE has a reported sensitivity and specificity for detecting polyps > 9 mm of 87% and 95%, respectively [4]. Two studies, of 50 and 62 patients, have investigated the accuracy of CCE compared with colonoscopy in immunochemical FOBT (IFOBT) positive screening individuals, reporting sensitivities and specificities for polyps > 9 mm of 89-93% and 92-96%, respectively [3,5]. The present study is currently the largest trial investigating the polyp detection rate (PDR) and accuracy of second generation CCE compared with OC in an IFOBT positive screening population.…”

Colon capsule endoscopy: toward the future

“…To date, five studies have been published on polyp detection by CCE-2 compared with conventional colonoscopy [27][28][29][30][31]. These studies highlighted the considerably high sensitivity and specificity of CCE-2.…”