Colon cancer in argentina. I: Risk from intake of dietary items

Iscovich, José; L'Abbé, Kristan A.; Castelleto, R; Calzona, A.; Bernedo, Alberto; Chopita, N; Jmelnitzsky, A. C.; Kaldor, John

doi:10.1002/ijc.2910510603

Cited by 104 publications

(46 citation statements)

References 22 publications

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“…9,40,45,46 In our study, frequent consumption of dairy foods (but not high mean daily intakes) was associated with increased risk, but only in AfricanAmericans. It has been suggested that the elevated risk observed in some studies may be attributable to the fat content of dairy foods, whereas decreased risk may be due to calcium or vitamin D content.…”

Section: Discussionmentioning

confidence: 42%

Food groups and colon cancer risk in African‐Americans and Caucasians

Satia-Abouta

Galanko

Martin

et al. 2004

Intl Journal of Cancer

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The disparities in colon cancer incidence between AfricanAmericans and other U.S. ethnic groups are largely unexplained. This report examines associations of various food groups with colon cancer in African-Americans and Caucasians from a case-control study. Incident cases of histologically confirmed colon cancer, age 40 -80 years, (n ‫؍‬ 613) and matched controls (n ‫؍‬ 996) were interviewed in-person to ascertain potential colon cancer risk factors. Diet over the year before diagnosis or interview date was assessed using a validated food frequency questionnaire adapted to include regional foods. Multivariate logistic regression models estimated energy-adjusted and non-energy adjusted odds ratios (OR). Controls generally reported higher consumption (daily amount and weekly frequency) of fruits, vegetables and dark green, deep yellow fruits/vegetables, whereas cases consumed more refined carbohydrates and fats, oils and snacks. Regardless of ethnic group or energy adjustment, high and frequent vegetable consumption (particularly dark green vegetables) was protective, consistent with 20 -50% reductions in risk. In Caucasians, high refined carbohydrate and red meat consumption (amount and frequency) was associated with a statistically significant 2-fold increased risk in non-energy adjusted models. In African-Americans, frequent intake of dairy foods was associated with a doubling in risk (OR ‫؍‬ 1.9, 95% CI ‫؍‬ 1.1-3.4) in non-energy-adjusted models, whereas frequent fruit consumption correlated with a nonsignificant 30% lower risk. These findings add to growing evidence that plant foods may protect against colon cancer; however, the effects of the other food groups varied by ethnic group and energy adjustment. These results may also explain some of the ethnic differences in colon cancer incidence. © 2004 Wiley-Liss, Inc. Key words: African-Americans; colon cancer; diet; foods; food groups; ethnic group; CaucasiansCarcinoma of the colon is one of the most common cancers in developed countries. 1 In the United States (U.S.), colon cancer is the second leading cause of cancer death and the third most common cancer among adults, accounting for approximately 15% of all cancers diagnosed annually. 2,3 The American Cancer Society projects that in the year 2003, 147,500 new colon and rectal cancer cases will be diagnosed and an estimated 57,100 persons will die from these cancers. 4 Colon cancer incidence and mortality vary markedly by ethnic group; specifically, African-Americans have the highest incidence and mortality rates among all U.S. ethnic groups. 3,4 Between 1992-99, for example, colon and rectal cancer incidence and mortality rates were 61.9 and 29.1 per 100,000 respectively among African-Americans. In contrast, for Caucasians, these rates were 51.9 and 21.9 per 100,000, respectively. 3 The reasons for ethnic differences in incidence rates for colon cancer are largely unknown. Socioeconomic, behavioral, cultural and health care differences undoubtedly contribute to some of these disparities but do not complet...

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Section: Discussionmentioning

confidence: 42%

Food groups and colon cancer risk in African‐Americans and Caucasians

Satia-Abouta

Galanko

Martin

et al. 2004

Intl Journal of Cancer

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“…Two other case -control studies (Iscovich et al, 1992;Shannon et al, 1996) reported higher odds ratios for high-fat than for low-fat dairy intake, but the association was not statistically significant. An American hospital-based case -control study on patterns of milk consumption and risk of different cancers found a significant increased risk in subjects that consumed whole milk daily compared to non-consumers (Mettlin et al, 1990).…”

Section: Yoghurtmentioning

confidence: 96%

“…The ORs for the highest category of consumption vs the lowest are summarized in Figure 1. Out of 11 case -control studies, three found a significant risk increase (Benito et al, 1990;Iscovich et al, 1992;Steinmetz & Potter, 1993) and three other studies a significantly decreased risk (Shannon et al, 1996;Kampman et al, 2000;Murata et al, 1999). The diversity of dairy products may to some extent explain the inconsistencies of these results.…”

Section: Total Dairy Productsmentioning

confidence: 99%

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

2003

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Objectives: This review provides an overview of the principal hypotheses and epidemiological evidence of the possible links between colorectal cancer and intake of milk and=or dairy products. Methods: The first section outlines the main hypotheses about the possible effect of calcium, vitamin D, fats and other milk components. The possible role of acid lactic bateria in fermented products is also discussed. The second section is a summary of the published epidemiological evidence. The results on milk, cheese and yoghurt are summarized using a meta-analytical approach. The results of studies on calcium and vitamin D are briefly described. Results: Case -control studies are heterogeneous and, on average, do not provide evidence of association between total intake of total dairy products, milk, cheese or yoghurt and colorectal cancer risk. The average result from cohort studies support the hypothesis of a protective effect of total dairy products (odds ratio (OR): 0.62; 95% confidence interval (CI): 0.52 -0.74; P heterogeneity test: 0.93) and for milk (OR: 0.80; 95% CI: 0.68 -0.95; P heterogeneity: 0.77). No association was found between cheese (OR: 1.10; 95% CI: 0.88 -1.36; P heterogeneity: 0.55) or yoghurt (OR: 1.03; 95% CI: 0.83 -1.28; P heterogeneity: 0.69) in cohort studies. Conclusions: Cohort studies consistently found a protective effect of total dairy products and milk intake, but the evidence is not supported by case -control studies. No relationship was found with cheese or yoghurt intake. As the number of cohort studies is still limited, their results need to be confirmed by other prospective studies.

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“…Table 1 contains 30 case -control studies that had at least 99 cases and reported on meat intake (Benito et al, 1990;Bidoli et al, 1992;Centonze et al, 1994;Dales et al, 1979;Gerhardsson et al, 1991;Graham et al, 1978;Haenszel et al, 1973Haenszel et al, , 1980Hu et al, 1991;Iscovich et al, 1992;Kampman et al, 1995Kampman et al, , 1999Kato et al, 1990;Kune et al, 1987; La Vecchia (1992) 248 Italy Yes I R þ beef & pork; C-ve Centonze et al (1994) 118 Italy Yes H NS Dales et al (1979) 99 US Blacks -I N S Gerhardsson et al (1991) 559 Sweden Yes H C and R þ meats Graham et al (1978)) 586 USA (NY) -I N S Haenszel et al (1973) 179 Japanese in Hawaii -L CRC þ meat Heanszel et al (1980) 588 Japan --NS Hu et al (1991) 336 China Yes -NS Iscovich et al (1992) 110 Argentina Yes H NS Kampman et al (1995) 312 Netherlands Yes H NS Kampman et al (1999) 1542 USA Multicentre --NS Kato et al (1990) 221 Japan -I N S Kune et al (1987) 715 Australia Yes -C þ beef men, not women R þ lamb women, not men La Vecchia et al (1988) 575 N. Italy Yes -RR 2.0 CRC for meat but 3.0 for pasta þ rice La Vecchia et al (1996) 1326 N. Itlay -H CRC þ (1.6) for red meat Lee et al (1989) 203 Singapore Yes H NS Lyon et al (1988) 246 Utah, USA Yes -NS Macquart-Moulin et al (1986) 399 France Yes I NS Manousos et al (1983) 100 Greece Yes -CRC þ beef and lamb Miller et al (1983) 542 Canada Yes -R þ beef (?) Muscat et al (1994) 511 USA --NS Peters et al (1989) 146 Los Angeles, USA Yes -NS Peters et al (1992) 746 Los Angeles, USA Yes H NS Steinmetz et al (1993)…”

Section: The Case -Control Studiesmentioning

confidence: 99%

Meat consumption and cancer of the large bowel

2002

Eur J Clin Nutr

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studies relating (red) meat consumption and colorectal cancer have been published or found by search. These are collected here.Thirty adequate case -control studies have been published up to 1999 (from 16 different countries). Twenty of them found no significant association of (red) meat with colorectal cancer. Of the remaining 10 studies reporting an association, some obtained statistical significance only in rectal or colon cancers, another only in men, not women, or found a stronger association with pasta and rice, or used an inadequate food list in the food frequency questionnaire.Fifteen cohort studies have now been published. { Only in three were significant associations of (red) meat found with colorectal cancer. Two of these positive studies were from the same group in the USA (relative risk 1.7). The results of the third positive study appear to conflict with data from part of the vegetarians follow up mortality study.Here, five groups of vegetarians (in three different countries) with socially matched controls were followed up (total 76 000 people). Mortality from colorectal cancer was not distinguishable between vegetarians and controls.While it is still possible that certain processed meats or sausages (with a variety of added ingredients) or meats cooked at very high temperature carry some risk, the relationship between meats in general and colorectal cancer now looks weaker than the 'probable' status it was judged to have by the WCRF in 1997.

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Colon cancer in argentina. I: Risk from intake of dietary items

Cited by 104 publications

References 22 publications

Food groups and colon cancer risk in African‐Americans and Caucasians

Food groups and colon cancer risk in African‐Americans and Caucasians

Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence

Meat consumption and cancer of the large bowel

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