Meat consumption and cancer of the large bowel

As, Truswell

doi:10.1038/sj.ejcn.1601349

Cited by 39 publications

(29 citation statements)

References 31 publications

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“…1 27 Red meat consumption was considered a probable risk factor for colorectal cancer in the 1997 WCRF report (1). Since then, several other expert groups have reassessed the epidemiological data, including those published after the WCRF report (18)(19)(20)(21)(22)(23)(24)(25). Similar to our data, the results of many of these studies did not reach statistically significant levels.…”

Section: Downloaded By [North West University] At 12:31 20 December 2014supporting

confidence: 63%

Diet and Colorectal Cancer Mortality: Results From the Japan Collaborative Cohort Study

Kojima¹,

Wakai²,

Koji³

et al. 2004

Nutrition and Cancer

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The relationship between diet and colorectal cancer mortality was analyzed in a prospective study of 45,181 men and 62,643 women aged 40-79 yr enrolled in the Japan Collaborative Cohort Study. Between 1988 and 1990, sub-jects completed a self-administered questionnaire on their sociodemographic characteristics, diet, and other lifestyle habits. During the follow-up period (average 9.9 yr), 284 colon cancer deaths (138 men and 146 women) and 173 rectal cancer deaths (116 men and 57 women) were confirmed. The only significant association of colorectal cancer mortality with vegetable intake was observed between male rectal cancer mortality and green leafy vegetable consumption [hazard ratio (HR) using Cox proportional hazard models = 0.6; 95% confidence interval (CI) = 0.3-0.9; P for trend = 0.02]. Yogurt intake was also inversely associated with male rectal cancer mortality (HR = 0.5; 95% CI = 0.2-1.0; P for trend = 0.04). Egg consumption was positively associated with male colon cancer mortality (P for trend = 0.04). Women with high fruit consumption had increased colon cancer mortality (HR = 1.6; 95% CI = 1.0-2.6; P for trend = 0.04). It should be noted that this study lacked statistical power due to small sample size and measurement error in the food-frequency questionnaire. Further investigation is therefore necessary to confirm the association between diet and colorectal cancer, especially by subsites and gender.

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Section: Downloaded By [North West University] At 12:31 20 December 2014supporting

confidence: 63%

Diet and Colorectal Cancer Mortality: Results From the Japan Collaborative Cohort Study

Kojima¹,

Wakai²,

Koji³

et al. 2004

Nutrition and Cancer

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“…Debates about the potential role of red meat consumption in colorectal carcinogenesis have been especially pronounced [World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR), 1997; Truswell, 2002;Gonzalez and Riboli, 2006;Baghurst, 2007; World Cancer Research Fund (WCRF)/American Institute for Cancer Research, 2007;Boyle et al, 2008;Huxley et al, 2009;Truswell, 2009;McAfee et al, 2010]. For example, the World Cancer Research Fund (WCRF) in collaboration with the American Institute for Cancer Research (AICR) judged that red meat is a convincing cause of CRC in a report published in 2007 [World Cancer Research Fund (WCRF)/ American Institute for Cancer Research, 2007].…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of prospective studies of red meat consumption and colorectal cancer

Alexander

Weed²,

Cushing³

et al. 2011

European Journal of Cancer Prevention

121

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The relationship between red meat consumption and colorectal cancer (CRC) has been the subject of scientific debate. To estimate the summary association between red meat intake and CRC and to examine sources of heterogeneity, a meta-analysis of prospective studies was conducted. Thirty-four prospective studies of red meat and CRC were identified, of which 25 represented independent nonoverlapping study populations. Summary relative risk estimates (SRREs) for high versus low intake and dose-response relationships were calculated. In the high versus low intake meta-analysis, the SRRE was 1.12 (95% CI: 1.04-1.21) with significant heterogeneity (P=0.014). Summary associations were modified by tumor site and sex. The SRREs for colon cancer and rectal cancer were 1.11 (95% CI: 1.03-1.19) and 1.19 (95% CI: 0.97-1.46), respectively. The SRREs among men and women were 1.21 (95% CI: 1.04-1.42) and 1.01 (95% CI: 0.87-1.17), respectively. The available epidemiologic data are not sufficient to support an independent and unequivocal positive association between red meat intake and CRC. This conclusion is based on summary associations that are weak in magnitude, heterogeneity across studies, inconsistent patterns of associations across the subgroup analyses, and the likely influence of confounding by other dietary and lifestyle factors.

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“…[1][2][3][4] Epidemiologic studies have shown that not only prostate cancer but also colorectal carcinoma (CRC) has positive correlation with consumption of red and processed meat. [5][6][7][8] Recently, AMACR has been demonstrated to be overexpressed in primary and metastatic prostate cancers, and it has been used as an important diagnostic marker in the prostate to distinguish normal glands from prostate cancer. [9][10][11][12] However, in contrast to prostate cancer, there has been limited investigation of this enzyme in CRC.…”

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confidence: 99%

Alpha-methylacyl-CoA Racemase/P504S Overexpression in Colorectal Carcinoma is Correlated With Tumor Differentiation

Shi

Gong²,

Wu³

2007

Applied Immunohistochemistry &Amp; Molecular Morphology

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Alpha-methylacyl-CoA racemase (AMACR)/P504S is an enzyme involved in the metabolism of branched-chain fatty acids. Little is known about correlation of AMACR expression with colorectal carcinoma (CRC) differentiation and prognosis. We investigated the expression of AMACR in 106 cases of primary CRC, and in 47 lymph nodes with metastatic CRC by immunohistochemical analysis. These cases were divided into 3 groups according to the histologic differentiation of the primary tumors. group A included 50 cases of histologically well and moderately differentiated CRCs, 20 of these with lymph node metastasis; group B included 23 cases of well and moderately differentiated CRCs, histologically similar to group A, except these tumors had small foci (less than 20%) of high-grade carcinoma, and 10 of these had lymph node metastasis; group C included 33 cases of poorly differentiated adenocarcinoma and undifferentiated carcinoma, 17 with lymph node metastasis. The results showed the overall positive rates of expression in primary and metastatic CRCs were 59.4% and 46.8%, respectively. Expression in groups A (76.0%) and B (69.6%) was much higher than that in group C (27.3%). In group B, although overexpression of AMACR in primary tumors was similar to that of group A, it was only seen in 30.0% of group B metastatic tumors, which was similar to the rate of expression in group C (23.5%). In contrast, rates of expression in group A primary and metastatic tumors were similar (80.0% and 75.0%). Positive staining for AMACR in benign epithelium adjacent to tumor was rare (<2%). No relation was found between AMACR expression and overall survival. Our findings support the view that the expression of AMACR in CRC is correlated with tumor differentiation.

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Meat consumption and cancer of the large bowel

Cited by 39 publications

References 31 publications

Diet and Colorectal Cancer Mortality: Results From the Japan Collaborative Cohort Study

Diet and Colorectal Cancer Mortality: Results From the Japan Collaborative Cohort Study

Meta-analysis of prospective studies of red meat consumption and colorectal cancer

Alpha-methylacyl-CoA Racemase/P504S Overexpression in Colorectal Carcinoma is Correlated With Tumor Differentiation

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