Colon Cancer and Other Gastrointestinal Malignancies

Enzinger, Peter C.; Mayer, Robert J.

doi:10.1007/0-387-22621-4_35

Cited by 4 publications

(3 citation statements)

References 214 publications

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“…Of the various options, a combination of cisplatin and irinotecan can potentially provide significant activity against both components. This regimen was shown to be superior to cisplatin/etoposide in pulmonary SmCC (Noda et al, 2002) and to be very active in gastro-oesophageal adenocarcinoma (Enzinger et al, 1998). Moreover, irinotecan is now considered one of the two most effective agents against colorectal cancer (Rougier and Mitry, 2001).…”

Section: Discussionmentioning

confidence: 99%

Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases

et al. 2004

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Small-cell carcinoma (SmCC) of the gastrointestinal tract is a very rare and aggressive malignancy. To better define its clinicopathological features, the records of all patients with this disease seen at Memorial Sloan Kettering Cancer Center between 1980 and 2002 (n ¼ 64) were reviewed. The most common primary tumour locations were in the large bowel and oesophagus. Predisposing medical conditions for non-small-cell cancers, positive family cancer history, and metachronous tumours were common. In all, 37% had mixed tumour histology and 48% presented with extensive disease, according to the Veterans' Administration Lung Study group (VALSG) staging system used for small-cell lung cancer. Treatment outcome in limited disease (LD) suggested a role for surgery and chemotherapy. Platinum-based regimens resulted in a 50% response rate. The 2-year survival was 23% and two prognostic factors were identified, the extent of disease according to the VALSG system (Po0.01) and TNM stage (P ¼ 0.03). Anatomic location had no clinical impact. In conclusion, SmCC from various gastrointestinal sites can be viewed as one clinical entity. Mixed tumour histology is common and may affect therapy. Surgery, combined with chemotherapy, should be considered for LD. The value of the VALSG system was implied and possible differences from small-cell lung cancer were noted.

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Section: Discussionmentioning

confidence: 99%

Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases

et al. 2004

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“…In India, according to National Cancer Registry, esophageal cancers rank third after carcinoma Breast and Cervix [1][2][3]. Early detection of malignancy greatly improves the survival rate of patients.…”

Section: Introductionmentioning

confidence: 99%

Cyto Histological Correlation of Brush Cytology with Biopsy in Upper GI Lesions

Devi¹,

Toopalli²,

Kumar³

et al. 2016

SJAMS

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Neoplasms of upper gastrointestinal tract specially malignancy is one of the leading causes of death worldwide. Endoscopy has greatly facilitated the detection and diagnosis of gastrointestinal lesions. Early cancer is highly curable. Unfortunately most early cancers are asymptomatic. Brush cytology and biopsy are complimentary procedures for the detection of upper gastrointestinal neoplasms. 100 cases of non-neoplastic and neoplastic lesions were studied over a period of one year from January 2015 to December 2015 at the Department of Pathology, Gandhi Hospital/Medical College, Hyderabad, Telangana, India. Patients between 21 to 75 years of age presenting to the department of Gastroenterology with complaints of dysphagia, retrosternal pain, vomiting and loss of weight were included in the study. Endoscopy was done using flexible video endoscopy on patients with ulcer or polypoid and ulcerative growths in the upper GIT. Exfoliated cells from the lesion were collected by means of a brush introduced through the endosope. Smears were made by directly smearing the brush on to a slide and fixed with a spray fixative containing 95% ethyl alcohol. Slides were stained by Hematoxylin & Eosin and Papanicoulou stains. After brushing, multiple biopsies were taken from the representative area of the lesions. Cytohistological correlation was done. Brush cytology is a useful, inexpensive procedure that gives rapid diagnosis in cases of endoscopically visible suspicious lesions of upper GIT. It is an accurate diagnostic adjunct to biopsy in the detection of cancers at an early stage.

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“…Irinotecan in combination with cisplatin has significant activity in metastatic esophageal cancer and relieves dysphagia [103][104]. In vitro studies have demonstrated synergy for these drugs, and two trials have yielded encouraging results [104,105].…”

Section: New Emerging Therapiesmentioning

confidence: 99%

Multiple Management Modalities in Esophageal Cancer: Combined Modality Management Approaches

et al. 2004

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The overall success rate nationally in treating esophageal carcinomas remains poor, with over 90% of patients succumbing to the disease. In part I of this twopart series, we explored epidemiology, presentation and progression, work-up, and surgical approaches. In part II, we explore the promising suggestions of integrating chemotherapy and radiation therapy into the multimodal management of esophageal cancers.Alternative approaches to resection alone have been sought because of the overall poor survival rates of esophageal cancer patients, with failures occurring both localregionally and distantly. Concomitant chemotherapy and radiation therapy (XRT) have been shown, by randomized trial, to be more effective than XRT alone in treating unresectable esophageal cancers and also have shown promise as a neoadjuvant treatment when combined with surgery in the multimodal treatment of this disease. Various studies have also addressed issues such as preoperative chemotherapy, radiation dose escalation, chemotherapy/XRT as a definitive treatment versus use as a surgical adjuvant, and alternative chemotherapy regimens. There are suggestions of some progress, but this remains a difficult problem area in which management is continuing to evolve. The Oncologist 2004;9:147-159 The Oncologist 2004;9:147-159 www.TheOncologist.com Correspondence: Richard H. Matthews, M.D., Ph.D., Department of Radiation Oncology, Beth Israel/Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. Telephone: 617-232-9500, ext 4457 or ext 5628; Fax: 617-524-0643; e-mail: RHMatthews@comcast.net Received August 15, 2003; accepted for publication November 19, 2003. ©AlphaMed Press 1083-7159/2004 INTRODUCTIONThe long-term outlook for esophageal cancer patients, traditionally treated by surgical approaches, has been bleak.

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Colon Cancer and Other Gastrointestinal Malignancies

Cited by 4 publications

References 214 publications

Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases

Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases

Cyto Histological Correlation of Brush Cytology with Biopsy in Upper GI Lesions

Multiple Management Modalities in Esophageal Cancer: Combined Modality Management Approaches

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