Colocalization of taurine and glial fibrillary acidic protein immunoreactivity in mouse hippocampus induced by short-term ethanol exposure

Sakurai, Takanobu; Miki, Takanori; Li, Hong Peng; Miyatake, Akira; Satriotomo, Irawan; Takeuchi, Yoshiki

doi:10.1016/s0006-8993(02)03611-9

Cited by 12 publications

(3 citation statements)

References 24 publications

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“…Here, we observed that the expression of GFAP increased in taurine plus manganese group compared to the manganese alone group. However, some studies have indicated that taurine treatment was associated with a reduced level of GFAP in rats after 3-nitropropionic acid exposure in the xenotransplantated neurons derived from the human teratocarcinoma cell line [30]. This discrepancy could be resulted from the difference in the length of taurine treatment.…”

Section: Discussionmentioning

confidence: 99%

Taurine improves the spatial learning and memory ability impaired by sub-chronic manganese exposure

Tang

Meng

et al. 2014

J Biomed Sci

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BackgroundExcessive manganese exposure induced cognitive deficit. Several lines of evidence have demonstrated that taurine improves cognitive impairment induced by numerous neurotoxins. However, the role of taurine on manganese-induced damages in learning and memory is still elusive. This goal of this study was to investigate the beneficial effect of taurine on learning and memory capacity impairment by manganese exposure in an animal model.ResultsThe escape latency in the Morris Water Maze test was significantly longer in the rats injected with manganese than that in the rats received both taurine and manganese. Similarly, the probe trial showed that the annulus crossings were significantly greater in the taurine plus manganese treated rats than those in the manganese-treated rats. However, the blood level of manganese was not altered by the taurine treatment. Interestingly, the exposure of manganese led to a significant increase in the acetylcholinesterase activity and an evidently decrease in the choline acetyltransferase activity, which were partially restored by the addition of taurine. Additionally, we identified 9 differentially expressed proteins between the rat hippocampus treated by manganese and the control or the manganese plus taurine in the proteomic analysis using the 2-dimensional gel electrophoresis followed by the tandem mass spectrometry (MS/MS). Most of these proteins play a role in energy metabolism, oxidative stress, inflammation, and neuron synapse.ConclusionsIn summary, taurine restores the activity of AChE and ChAT, which are critical for the regulation of acetylcholine. We have identified seven differentially expressed proteins specifically induced by manganese and two proteins induced by taurine from the rat hippocampus. Our results support that taurine improves the impaired learning and memory ability caused by excessive exposure of manganese.

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Section: Discussionmentioning

confidence: 99%

Taurine improves the spatial learning and memory ability impaired by sub-chronic manganese exposure

Tang

Meng

et al. 2014

J Biomed Sci

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“…ischemia, trauma and neurodegenerative diseases – and activated glial cells are traditionally thought to exert detrimental effects by releasing pro-inflammatory compounds and by inhibiting neuron regeneration [25]–[27]. Nevertheless, several studies suggest that reactive astrocytes may also contribute to the defense of neurons against oxidative stress [27]–[29]. In particular, it is now established that astrocytes contain high levels of reactive oxygen species (ROS) scavenger molecules and antioxidant enzymes, which are not only involved in the protection of astroglial cells against the deleterious effects of ROS [30] but may also play a critical role for neuron survival [31]–[33].…”

Section: Introductionmentioning

confidence: 99%

The Octadecaneuropeptide ODN Protects Astrocytes against Hydrogen Peroxide-Induced Apoptosis via a PKA/MAPK-Dependent Mechanism

et al. 2012

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Astrocytes synthesize and release endozepines, a family of regulatory peptides, including the octadecaneuropeptide (ODN) an endogenous ligand of both central-type benzodiazepine (CBR) and metabotropic receptors. We have recently shown that ODN exerts a protective effect against hydrogen peroxide (H2O2)-induced oxidative stress in astrocytes. The purpose of the present study was to determine the type of receptor and the transduction pathways involved in the protective effect of ODN in cultured rat astrocytes. We have first observed a protective activity of ODN at very low concentrations that was abrogated by the metabotropic ODN receptor antagonist cyclo1–8[DLeu5]OP, but not by the CBR antagonist flumazenil. We have also found that the metabotropic ODN receptor is positively coupled to adenylyl cyclase in astrocytes and that the glioprotective action of ODN upon H2O2-induced astrocyte death is PKA- and MEK-dependent, but PLC/PKC-independent. Downstream of PKA, ODN induced ERK phosphorylation, which in turn activated the expression of the anti-apoptotic gene Bcl-2 and blocked the stimulation by H2O2 of the pro-apoptotic gene Bax. The effect of ODN on the Bax/Bcl-2 balance contributed to abolish the deleterious action of H2O2 on mitochondrial membrane integrity and caspase-3 activation. Finally, the inhibitory effect of ODN on caspase-3 activity was shown to be PKA and MEK-dependent. In conclusion, the present results demonstrate that the potent glioprotective action of ODN against oxidative stress involves the metabotropic ODN receptor coupled to the PKA/ERK-kinase pathway to inhibit caspase-3 activation.

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“…In the brain, acute ethanol administration causes different SCAA metabolic patterns with long-term addiction to alcoholism. It was reported that an acute single-dose alcohol administration stimulates taurine release in neurons whereas long-term addiction lowers taurine levels [20,21]. Presumably, SCAA alterations may diversify during alcohol withdrawal in alcoholic patients [22].…”

Section: Discussionmentioning

confidence: 99%

Effects of consecutive high-dose alcohol administration on the utilization of sulfur-containing amino acids by rats

Yang

Chen

Chiu

et al. 2006

The Journal of Nutritional Biochemistry

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Colocalization of taurine and glial fibrillary acidic protein immunoreactivity in mouse hippocampus induced by short-term ethanol exposure

Cited by 12 publications

References 24 publications

Taurine improves the spatial learning and memory ability impaired by sub-chronic manganese exposure

Taurine improves the spatial learning and memory ability impaired by sub-chronic manganese exposure

The Octadecaneuropeptide ODN Protects Astrocytes against Hydrogen Peroxide-Induced Apoptosis via a PKA/MAPK-Dependent Mechanism

Effects of consecutive high-dose alcohol administration on the utilization of sulfur-containing amino acids by rats

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