Effects of consecutive high-dose alcohol administration on the utilization of sulfur-containing amino acids by rats

Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice

“…First, we only exposed animals to a single dose of PERC, which is fairly high and is not likely to occur in environmental exposure scenarios. Extrapolating these data to environmentally relevant exposure levels may be a source of uncertainty (Bois et al, 1996(Bois et al, , 2000Yang et al, 2006). Furthermore, because PERC oxidative metabolism is saturable (Buben and O'Flaherty, 1985;Green et al, 1990), the types of kinetics observed in our study may not be fully representative of what occurs in environmentally exposed humans.…”

Taurine supplementation improves the utilization of sulfur-containing amino acids in rats continually administrated alcohol

“…[2][3][4][5]. Both chronic and acute alcohol consumption in our previous study produced transsulfuration dysregulation [15]. Ethanol interrupts vitamin B 6 absorption and circulation in nearly 51.5% of alcoholics [9].…”

“…Moreover, acamprosate, a derivative of taurine, is now approved for use in alcohol withdrawal [14]. Since we previously reported that acute ethanol gavagement produced dramatic imbalances in the SCAA metabolism in various tissues, especially the brain, a significant correlation between changed plasma levels of pyridoxal-5′-phosphate (PLP) and taurine was reported [15]. The results indicated strong influences on taurine and transsulfuration under ethanol intake.…”

Use of metabolomics to elucidate the metabolic perturbation associated with hypertension in a black South African male cohort: the SABPA study

“…Lowered SAM will cause lowered protein methylation and result in lower urinary TML, as observed in the hypertensive group. Chronic alcohol metabolism is also linked to lowered pyridoxal-5-phosphate (PLP) levels 49 and may be responsible for the lowered 3-indole carboxylic acid glucuronide detected in the hypertensives. Furthermore chronic alcohol metabolism is linked to lowered GSH levels [50][51][52] Although GSH was not significantly lower in the hypertensive group, the lowered kynurenic acid detected in the hypertensives could be due to slightly lower GSH levels available for detoxification via glucuronidation.…”