Colocalization of neuropeptides with calcium-binding proteins in the claustral interneurons during postnatal development of the rat

Kowiański, Przemysław; Dziewíatkowski, J; Moryś, Janusz; Majak, Katarzyna; Wójcik, Sławomir; Edelstein, Lawrence; Lietzau, Grażyna

doi:10.1016/j.brainresbull.2009.06.020

Cited by 26 publications

(27 citation statements)

References 34 publications

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“…The fact that nNOS-immunoreactivity was observed in neurons of varying shapes and sizes suggest that these cells play differing roles in the context of claustral function (Kowianski et al 2002). Kowianski et al (2003) proved a co-localization between nNOS and calbindin (CB) in DC neurons. Same authors reported also a co-localization between nNOS and parvalbumin (PV).…”

Section: Discussionmentioning

confidence: 98%

Neuronal nitric oxide synthase immunopositive neurons in cat claustrum—a light and electron microscopic study

Hinova-Palova

Edelstein²,

Paloff

et al. 2008

J Mol Hist

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Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. Nevertheless there are little data about the neuronal Nitric Oxide Synthase immunoreactive (nNOS-ir) neurons and fibers in the dorsal claustrum (DC) of a cat. In this respect the aims of this study were: (1) to demonstrate nNOS-ir in the neurons and fibers of the DC; (2) to describe their light microscopic morphology and distribution; (3) to investigate and analyze the ultrastructure of the nNOS-ir neurons, fibers and synaptic terminals; (4) to verify whether the nNOS-ir neurons consist a specific subpopulation of claustral neurons; (5) to verify whether the nNOS-ir neurons have a specific pattern of organization throughout the DC. For demonstration of the nNOS-ir the Avidin-Biotin-Peroxidase Complex method was applied. Immunopositive for nNOS neurons and fibers were present in all parts of DC. On the light microscope level nNOS-ir neurons were different in shape and size. According to the latter they were divided into three groups-small (with diameter under 15 microm), medium-sized (with diameter from 16 to 20 microm) and large (with diameter over 21 microm). Some of nNOS-ir neurons were lightly-stained while others were darkly-stained. On the electron microscope level the immunoproduct was observed in neurons, dendrites and terminal boutons. Different types of nNOS-ir neurons differ according to their ultrastructural features. Three types of nNOS-ir synaptic boutons were found. As a conclusion we hope that the present study will contribute to a better understanding of the functioning of the DC in cat and that some of the data presented could be extrapolated to other mammals, including human.

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Section: Discussionmentioning

confidence: 98%

Neuronal nitric oxide synthase immunopositive neurons in cat claustrum—a light and electron microscopic study

Hinova-Palova

Edelstein²,

Paloff

et al. 2008

J Mol Hist

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“…Each class was found throughout the entire claustrum, in all functionally defined subdivisions. Kowianski et al (2009) report the following co-localizations of neuropeptides in the interneurons of the claustrum in rat brain:…”

Section: The Role Of Gabaergic Interneuronsmentioning

confidence: 99%

Hypotheses Relating to the Function of the Claustrum

2014

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“…In general, CNS neurons can be functionally divided into two major types: main glutaminergic neurons and GABA-ergic interneurons (Clements et al 2008, Kowiański et al 2009, Schwaller et al 2002. In the mammals, the majority of Cl and EN neurons belong to the group of main neurons whereas only 6-12% consisted of interneurons (Gómez-Urquijo et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Further immunohistochemical studies clearly showed that both in Cl and EN, CaBPs-containing neurons are predominantly glutamatergic as well as GABA-ergic in nature , Kowiański et al 2009). Most CaBPs belong to the same protein superfamily and share the common EF-hand calcium-binding motif (Kretsinger and Nockolds 1973).…”

Section: Introductionmentioning

confidence: 99%

Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

Szalak¹,

Matysek²,

Mozel³

et al. 2015

Polish Journal of Veterinary Sciences

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Calretinin (CR) as a buffer and sensor protein plays an important role in regulatory processes of Ca 2+ and anty-apoptotic cellular protection. In the present study, immunohistochemical peroxidase-antiperoxidase (PAP) method was used in order to determine the numbers, morphology, morphometry and distribution pattern of CR in neurons of the chinchilla's claustrum (Cl) and endopiriform nucleus (EN). In Cl and EN the presence of several classes of neurons with different immunoreactivity to CR was found. In Cl, CR-immunoreactive (IR) neurons were predominantly found in close vicinity to insular border while CR-IR neurons were evenly scattered throughout EN. In general, immunoreaction to CR was observed in neuronal cytoplasm, nucleus and in fibres-like nerve extensions. Statistical analysis showed the differences between average large diameter as well as cross-sectional area of CR-IR neurons present in Cl and EN. It is suggested, that CR acting as a calcium binding protein may play a role in neuronal network. Further co-localization studies are necessary to fully elucidate neurophysiology and neuropathology of the chinchilla's Cl and EN neurons.

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Colocalization of neuropeptides with calcium-binding proteins in the claustral interneurons during postnatal development of the rat

Cited by 26 publications

References 34 publications

Neuronal nitric oxide synthase immunopositive neurons in cat claustrum—a light and electron microscopic study

Neuronal nitric oxide synthase immunopositive neurons in cat claustrum—a light and electron microscopic study

Hypotheses Relating to the Function of the Claustrum

Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

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