Hypotheses Relating to the Function of the Claustrum

Smythies, J. R.; Edelstein, Lawrence; Ramachandran, Vilayanur S.

doi:10.1016/b978-0-12-404566-8.00013-1

Cited by 46 publications

(61 citation statements)

References 157 publications

(142 reference statements)

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“…The claustrum is known to maintain a (bilateral, mainly ipsilateral) roughly topographic bidirectional connection with the whole isocortex and the pallial amygdala, with cortical layer 6a neurons providing the main claustrum afferents and claustral cortical projections ending preferentially in layers 1 and 6. There is much current interest in a possibly "binding" functional nature of these claustro-cortical connections, rather than as an example of sensorimotor processing [Smythies et al, 2014]. The claustrum also projects to the thalamus.…”

Section: Connectivity Of the Claustro-insular Lpall With Thoughts Onmentioning

confidence: 99%

“…In rats, the topography of such partial connections is coarse, with marked overlaps [Druga, 2014]. The insula receives afferents from some sensory thalamic nuclei (particularly pain, visceroceptive, and gustatory inputs), is reciprocally connected with the amygdala as well as with limbic and association cortical areas, and is implicated in widely different functions ranging from pain perception and speech production to the processing of social distaste emotions [Lundy and Norgren, 2004;Whitehead, 2012;Nieuwenhuys, 2012;Smythies et al, 2014]. Massive bilateral lesion of the insula in humans reportedly is not accompanied by a loss of consciousness [Philippi et al, 2012].…”

Section: Connectivity Of the Claustro-insular Lpall With Thoughts Onmentioning

confidence: 99%

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Comments on the Updated Tetrapartite Pallium Model in the Mouse and Chick, Featuring a Homologous Claustro-Insular Complex

Puelles

2017

Brain Behav Evol

133

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This essay reviews step by step the conceptual changes of the updated tetrapartite pallium model from its tripartite and early tetrapartite antecedents. The crucial observations in mouse material are explained first in the context of assumptions, tentative interpretations, and literature data. Errors and the solutions offered to resolve them are made explicit. Next, attention is centered on the lateral pallium sector of the updated model, whose definition is novel in incorporating a claustro-insular complex distinct from both olfactory centers (ventral pallium) and the isocortex (dorsal pallium). The general validity of the model is postulated at least for tetrapods. Genoarchitectonic studies performed to check the presence of a claustro-insular field homolog in the avian brain are reviewed next. These studies have indeed revealed the existence of such a complex in the avian mesopallium (though stratified outside-in rather than inside-out as in mammals), and there are indications that the same pattern may be found in reptiles as well. Peculiar pallio-pallial tangential migratory phenomena are apparently shared as well between mice and chicks. The issue of whether the avian mesopallium has connections that are similar to the known connections of the mammalian claustro-insular complex is considered next. Accrued data are consistent with similar connections for the avian insula homolog, but they are judged to be insufficient to reach definitive conclusions about the avian claustrum. An aside discusses that conserved connections are not a necessary feature of field-homologous neural centers. Finally, the present scenario on the evolution of the pallium of sauropsids and mammals is briefly visited, as highlighted by the updated tetrapartite model and present results.

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Section: Connectivity Of the Claustro-insular Lpall With Thoughts Onmentioning

confidence: 99%

Section: Connectivity Of the Claustro-insular Lpall With Thoughts Onmentioning

confidence: 99%

Comments on the Updated Tetrapartite Pallium Model in the Mouse and Chick, Featuring a Homologous Claustro-Insular Complex

Puelles

2017

Brain Behav Evol

133

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“…Smythies and colleagues [13,14,58,59••] subsequently presented a more detailed hypothesis about how such temporal integration might occur based on higher-order temporal synchronization and the neuroanatomy of the claustrum. The claustrum is broadly divided into 3 sub-regions, the anterior-dorsal region connected with somatosensory and motor cortices, a posterior dorsal region connected with the visual cortex, and a ventral area connected to the auditory cortex [60, 61, 62••, 63, 64, 65•].…”

Section: Claustrum and Consciousnessmentioning

confidence: 99%

“…In recent years, the claustrum was proposed as a possible neural candidate for the coordination of conscious awareness [13,14] and to play a key role in integrating diverse sources of neural information during the formation of unified conscious percepts [15,16]. The interhemispheric connections of the claustrum enable the coordination of bilateral cortical functions by way of its ipsilateral and contralateral connections with prefrontal, premotor, and motor areas.…”

Section: Introductionmentioning

confidence: 99%

Claustrum, consciousness, and time perception

Yin

Terhune

Smythies

et al. 2016

Current Opinion in Behavioral Sciences

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The claustrum has been proposed as a possible neural candidate for the coordination of conscious experience due to its extensive "connectome". Herein we propose that the claustrum contributes to consciousness by supporting the temporal integration of cortical oscillations in response to multisensory input. A close link between conscious awareness and interval timing is suggested by models of consciousness and conjunctive changes in meta-awareness and timing in multiple contexts and conditions. Using the striatal beat-frequency model of interval timing as a framework, we propose that the claustrum integrates varying frequencies of neural oscillations in different sensory cortices into a coherent pattern that binds different and overlapping temporal percepts into a unitary conscious representation. The proposed coordination of the striatum and claustrum allows for time-based dimensions of multisensory integration and decision-making to be incorporated into consciousness.

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“…The search for effective parameters requires months and after-effects must be factored in. Finally, given recent speculation about the role of the claustrum in "binding" consciousness (Smythies et al 2014), this could become the focus of future neurostimulation studies. …”

Section: Editor's Conclusionmentioning

confidence: 99%