Colloidal stability evolution and completely reversible aggregation of gold nanoparticles functionalized with rationally designed free radical initiators

Park, Hye Hun; Park, Hansoo; Jamison, Andrew C.; Lee, T. Randall

doi:10.1007/s00396-013-3071-1

Cited by 11 publications

(10 citation statements)

References 44 publications

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“…Spherical AuNP dispersions exhibited a characteristic Plasmon absorption band at 500–575 nm as measured by UV–vis spectrophotometer. These absorption values have dependency on AuNPs size and crystal structure . The absorption wavelength values are given in Table and indicated AuNP diameters to be between 5.0 and 10.0 nm (Fig.…”

Section: Resultsmentioning

confidence: 96%

Preparation of Cross‐Linked Micelles from Glycidyl Methacrylate Based Block Copolymers and Their Usages as Nanoreactors in the Preparation of Gold Nanoparticles

Koçak

Solmaz

Dikmen

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

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This study reports the synthesis of poly(ethylene glycol)methyl ether‐block‐poly(glycidyl methacrylate) (MPEG‐b‐PGMA) diblock, and poly(ethylene glycol)methyl ether‐block‐poly(glycidyl methacrylate)‐block‐poly(methyl methacrylate) (MPEG‐b‐PGMA‐b‐PMMA) triblock copolymers via atom transfer radical polymerization and their self‐assembly behaviors in aqueous media by using acetone as cosolvent. These block copolymers formed near monodisperse core–shell micelles having cross‐linkable cores. Two types of cross‐linked micelles, namely spherical MPEG‐b‐PGMA core cross‐linked (CCL) micelles and MPEG‐b‐PGMA‐b‐PMMA interlayer cross‐linked (ILCL) micelles, were also successfully prepared from these block copolymers by using various bifunctional cross‐linkers such as hexamethylenediamine (HMDA), ethylenediamine (EDA), and 2‐aminoethanethiol (AET). Cross‐linking was successfully carried out via ring‐opening reactions of epoxy residues of hydrophobic‐cores with primary amine or thiol groups of bifunctional cross‐linkers. Finally, these cross‐linked micelles were successfully used as nanoreactors in the synthesis of gold nanoparticles (AuNPs) in aqueous media. Both CCL and ILCL micelles were found to be good stabilizers for AuNPs in aqueous media. Both CCL‐ and ILCL‐stabilized AuNP dispersions were stable for a long time without any size changes and flocculation at room temperature. These cross‐linked stabilized AuNPs exhibited good catalytic activities in the reduction of p‐nitrophenol. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 514–526.

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Section: Resultsmentioning

confidence: 96%

Preparation of Cross‐Linked Micelles from Glycidyl Methacrylate Based Block Copolymers and Their Usages as Nanoreactors in the Preparation of Gold Nanoparticles

Koçak

Solmaz

Dikmen

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

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“…The sulfur atom of the thiol acts as the headgroup by binding to the gold surface of the nanoshell while exposing the bulky PEG2000 (tailgroup) toward the surrounding solution. The tailgroup of the initiator monolayer also provides steric hindrance between the nanoshell particles; the resulting steric hindrance disrupts the inter-particle interaction, which typically leads to nanoshell aggregation, allowing the nanoshells to be stable in aqueous solution for up to six months under ambient conditions [33].…”

Section: Resultsmentioning

confidence: 99%

“…Synthetic strategy used to prepare the free radical initiator HSPEG2000 [33]. DCC, N , N ′-dicyclohexylcarbodiimide; DMAP, 4-dimethylaminopyridine.…”

Section: Figures and Schemesmentioning

confidence: 99%

“…The P(NIPAM- co -AA) shell was generated through the free radical polymerization of the rationally-designed initiator HSPEG2000 (see Scheme 2), synthesized as described previously [33]. The morphology of the resultant hydrogel-coated nanoshells was studied with scanning electron microscopy (SEM), and the temperature-responsive behavior of the particles was characterized by dynamic light scattering (DLS).…”

Section: Introductionmentioning

confidence: 99%

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Temperature-Responsive Hydrogel-Coated Gold Nanoshells

Park

Srisombat

Jamison

et al. 2018

Gels

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Abstract:Gold nanoshells (~160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system. The morphologies of the resultant hydrogel-coated nanoshells were analyzed by scanning electron microscopy (SEM), while the temperature-responsive behavior of the nanoparticles was characterized by dynamic light scattering (DLS). The diameter of the P(NIPAM-co-AA) encapsulated nanoshells decreased as the solution temperature was increased, indicating a collapse of the hydrogel layer with increasing temperatures. In addition, the optical properties of the composite nanoshells were studied by UV-visible spectroscopy. The surface plasmon resonance (SPR) peak of the hydrogel-coated nanoshells appeared at~800 nm, which lies within the tissue-transparent range that is important for biomedical applications. Furthermore, the periphery of the particles was conjugated with the model protein avidin to modify the hydrogel-coated nanoshells with a fluorescent-tagged biotin, biotin-4-fluorescein (biotin-4-FITC), for colorimetric imaging/monitoring.

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“…These nanostructures are interesting because SERS hot spots can be formed in these gaps, which is remarkably useful in the developement of drug delivery vehicles for therapeutic and imaging purposes or in situ monitoring of intracellular processes. For successful application of Au NPs in biological systems, Park and coworkers [12] studied the stability of the particles with a large variety of surface capping ligand and found the thiolated PEG as an advantageous material for stabilizing and for further surface modification, as well.…”

Section: Introductionmentioning

confidence: 99%

Interaction of biofunctionalized gold nanoparticles with model phospholipid membranes

Ábrahám¹,

Csapó²,

Bohus³

et al. 2014

Colloid Polym Sci

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The understanding of the interaction of nanoparticles with cell membranes and the penetration of these nanoobjects through cell wall is highly required for their biomedical application. In this work were aimed at the study of the interaction of gold nanoparticles with model phospholipid membranes prepared at the air/water interface in a Langmuir trough. Spherical (10 and 15 nm mean diameter) and rod-like gold (aspect ratio: 2.8) nanoparticles were synthesized and biofunctionalized with L-cysteine and L-glutathione. The gold nanoparticles were characterized by TEM images and UV-Vis absorbance measurements. The interaction of the biofunctionalized gold nanoparticles with the model monolayer membrane was studied by surface pressure versus surface area compressional isotherms and by the measurement of the change in surface pressure of a preformed model membrane. The effect of the initial surface pressure of the preformed membrane was evaluated to determine the maximum insertion pressure and synergy. We have found that the driving forces of the bioconjugated Au nanoparticle (NP) or Au nanorod (NR) penetration into the monolayer membrane is mostly determined by electrostatic interaction and orientational van der Waals forces. Monolayer films were transferred with Langmuir-Blodgett technique onto solid substrates and the nanoparticles were visualized with AFM technique.

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Colloidal stability evolution and completely reversible aggregation of gold nanoparticles functionalized with rationally designed free radical initiators

Cited by 11 publications

References 44 publications

Preparation of Cross‐Linked Micelles from Glycidyl Methacrylate Based Block Copolymers and Their Usages as Nanoreactors in the Preparation of Gold Nanoparticles

Preparation of Cross‐Linked Micelles from Glycidyl Methacrylate Based Block Copolymers and Their Usages as Nanoreactors in the Preparation of Gold Nanoparticles

Temperature-Responsive Hydrogel-Coated Gold Nanoshells

Interaction of biofunctionalized gold nanoparticles with model phospholipid membranes

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