Colloidal hydroxyethyl starch for tumor-targeted platinum delivery

Abstract

Hydroxyethyl starch (HES) was directly conjugated with cis-platinum prodrugviaan ester bond and decorated with active targeting molecule, lactobionic acid (LA), to afford LA-HES-Pt, which contributes toward higherin vitroantitumor activity against hepatoma carcinoma cells, HepG-2, as compared to cis-platinum.

Hydroxyethyl starch based smart nanomedicine

“…1C , the HES hydration diameter increases with the increase of the HES molecular weight, and decreases with the increase of the HES concentration, indicating that HES molecules are soft particles and can be compressed. 28 …”

“…Both the reported HES–CUR NPs and LA–HES–Pt have significant clinical translation potential and warrant further in vivo investigation. 28 …”

Doxorubicin-Bound Hydroxyethyl Starch Conjugate Nanoparticles with pH/Redox Responsive Linkage for Enhancing Antitumor Therapy

“…International Journal of Nanomedicine 2021: 16 37 °C with shaking at a speed of 100 rpm. At predetermined time points, 1 mL of medium was withdrawn and an equal volume of fresh media was replenished into the flask.…”

“…10,12,13 Among available biocompatible polymers, hydroxyethyl starch (HES), a biodegradable polysaccharide derivative, has attracted a lot of attention in conjugate construction because it has several meritorious characteristics such as full water solubility, tunable degradability, and modifiable functionalities. 9,[14][15][16] In particular, HES has been used as a plasma volume expander for years, making it notably advantageous over many other polymers for functioning as the conjugate backbone because of its high daily parenteral tolerance dose and good in vivo safety. 4,15 Several HES-based anticancer conjugates have already been developed, and they exhibit varying degrees of improvements in anticancer efficacy compared to their respective corresponding free drugs.…”

Delivery of Platinum(IV) Prodrugs via Bi2Te3 Nanoparticles for Photothermal–Chemotherapy and Photothermal/Photoacoustic Imaging

“…However, the efficacy of most typical platinum-based drugs such as cisplatin is affected by the inherent or acquired resistance of cancer cells or acquired resistance of cancer cells. , Platinum­(IV) prodrugs, which are considered to be the next-generation cisplatin-like platinum­(II) complexes, have obvious advantages . Platinum­(IV) prodrugs usually have low spin d 6 selective configurations and octahedral geometries, suggesting that they have high substitution kinetics inertia. , They also exhibited very high stabilities in blood and reduced side effects. , In addition, platinum­(IV) complexes are more flexible as a result of axial ligand functionalization and can regulate the properties of the released drug, such as its redox potential, water solubility, and lipophilicity. − Recently, various nanodrug delivery systems (nDDS) have been developed and reported to improve the efficacy of cisplatin CT. − nDDS can be used as Trojan horses to deliver drugs into cells through endocytosis, resulting in enhanced intracellular accumulation. , After entering the cells, platinum­(IV) prodrugs are reduced, and the cytotoxic platinum­(II) species are released to kill the cancer cells. , …”