Colloidal Gold Reaction in Multiple Sclerosis

Storch, Theodore J. C. von; Lawyer, Tiffany; Harris, Albert H.

doi:10.1001/archneurpsyc.1950.02310290064006

Cited by 9 publications

(1 citation statement)

References 5 publications

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“…The “colloidal gold curve” was used in the diagnosis of multiple sclerosis (MS) before the advent of modern techniques of protein separation and evaluation. [ 1 – 2 ] A “paretic” pattern (as in “general paresis” in syphilis of the central nervous system) or “first zone” elevation in this assay was considered corroborative of being diagnostic of this disorder. The basis of changes seen in the colloidal gold curve assay are not known but the first zone pattern described in this assay was probably a reflection of the presence of immunoglobulins in the CSF commonly seen in MS as well as in general paresis of syphilis.…”

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Cerebrospinal fluid in multiple sclerosis

Rammohan

2009

Ann Indian Acad Neurol

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Background:Technological advances have made it possible to examine the human cerebrospinal fluid (CSF) in a manner that was previously impossible. CSF provides a window into the changes that occur in the central nervous system (CNS) in health and disease. Through analysis of the CSF, we discern indirectly the state of health of the CNS, and correctly or incorrectly, draw conclusions regarding mechanisms of CNS injury and repair.Objective, Materials and Methods:To review the current state of knowledge of changes in the CSF in multiple sclerosis.Discussion:Establishing CSF markers that permit evaluation of the various biological processes in multiple sclerosis remains a challenge. Of all the biological processes, inflammatory markers are probably the best identified. Detection of oligoclonal immunoglobulin bands in the CSF is now established as the single most useful laboratory marker in the CSF to aid in the diagnosis of multiple sclerosis. Markers of demyelination, remyelination, neuro-axonal loss, neural repair and regeneration, and astrogliosis are only now being recognized. A good surrogate for any of these pathophysiological processes has not been defined to date.Conclusion:The goal of future research is not only to define surrogate markers in the CSF for each of the above functions, but also to extend it to other more readily accessible body fluids like blood and urine. A synopsis of the current literature in most of these areas of CSF evaluation pertaining to multiple sclerosis is presented in this article.

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Cerebrospinal fluid in multiple sclerosis

Rammohan

2009

Ann Indian Acad Neurol

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Die Produktion und Zirkulation des Liquors und ihre Störungen

Schaltenbrand¹,

Wolff²

1959

Grundlagen I

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Statistische Untersuchungen zum Problem der Multiplen Sklerose

Abb¹,

Schaltenbrand²

1956

Deutsche Zeitschrift f. Nervenheilkunde

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1950) : Early manifestation o' f 'disseminated sclerosis. Brit med. J., 2, 431-436. (1958) : Prognosis and treatment of Allison, R. S. (1950): Survival in disseminated sclerosis; a clirical study of a series of cases first seen twenty years ago. Brain 73, 103-120.Allison, R. S. and J. H . D. Millar (1954) : Prevalence and familial iuciderce of disseminated sclerosis: A repoit to the Northern Ireland Hospital Authority on the result of a threeyear survey. Ulster med.. J., 23, Suppl. 2. Allison, R. S. (1963) : Some neurological aspects of medical geography. Proc. roy. Soc. Med., 56, 71. Alter, M., R. S. Allison, 0. R . Talbert and Z. 2 ' . Kurland (1960): Geographic distribution of multiple sclerosis. Wld. Neurol., 1 , 5 5 4 8 . Alter, M., and J . F. Kwtzke (1968): The Epidemiology of multiple sclerosis. Charles C. Thomas, Springfield, Ill. Baker, A. B. (1968): Problems in the classification of multiple sclerosis. In Alter, M. and J. F. Kurtzke: The epidemiology of multiple sclerosis, p.p. 14-25. Charles C. Thomas. Springfield, Ill. Bummer, H . G . ( 1960) : Felduntersuchungen iiber Multiple Sklerose in Unterfranken, cine Studie an 110 Patienten in 46 Gemeinden. Thieme, Stuttgart. Berry, R. J. (1969) : Genetical factors in the etiology of multiple sclerosis. Acta neurol. scand. 45, 4 5 9 4 8 3 . Bonduelle, M. (1967) : Les formes benignes de la sclerose en plaques. Press med. 75/41, 2023-2026. Brain, 1. R. (1936) : Prognosis of disseminated sclerosis. Lancet, 2, 8 6 6 4 6 7 . Bramwell, B. (1917) : The prognosis of disseminated sclerosis. Duration in two hundred Broman, 2'. (1960) : Multiple sclerosis frequency in Goteborg. Acta psychiat ,,eurol. scand., Brown, J. R. (1969): Recent studies in multiple sclerosis: Inferences on rehabilitation andCarter, S., D. Sciarra and H. H. Merritt (1950) : The course of multiple sclerosis as deter-multiple sclerosis. Quantitative nosometric study. J. amer. med. Ass., 166, 1943. cases of disseminated sclerosis. Edinb. med. J., 18, 16-23. 35, suppl. 147, 23-29. employability. Proc. Mayo Clin., 44, 758-765. mined by autopsy proven cases, Proc. Ass. Res. nerv. ment. Dis., 28, 471-511.Committee on Medicai Rating of Physical Impairment (1963) : Guides to evaluation of permanent impairment. The central neurvous system. J. amer. med. Ass., 185, 2 6 3 5 .

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Colloidal Gold Reaction in Multiple Sclerosis

Cited by 9 publications

References 5 publications

Cerebrospinal fluid in multiple sclerosis

Cerebrospinal fluid in multiple sclerosis

Die Produktion und Zirkulation des Liquors und ihre Störungen

Statistische Untersuchungen zum Problem der Multiplen Sklerose

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