1950
DOI: 10.1001/archneurpsyc.1950.02310290064006
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Colloidal Gold Reaction in Multiple Sclerosis

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1956
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Cited by 9 publications
(1 citation statement)
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“…The “colloidal gold curve” was used in the diagnosis of multiple sclerosis (MS) before the advent of modern techniques of protein separation and evaluation. [ 1 2 ] A “paretic” pattern (as in “general paresis” in syphilis of the central nervous system) or “first zone” elevation in this assay was considered corroborative of being diagnostic of this disorder. The basis of changes seen in the colloidal gold curve assay are not known but the first zone pattern described in this assay was probably a reflection of the presence of immunoglobulins in the CSF commonly seen in MS as well as in general paresis of syphilis.…”
mentioning
confidence: 99%
“…The “colloidal gold curve” was used in the diagnosis of multiple sclerosis (MS) before the advent of modern techniques of protein separation and evaluation. [ 1 2 ] A “paretic” pattern (as in “general paresis” in syphilis of the central nervous system) or “first zone” elevation in this assay was considered corroborative of being diagnostic of this disorder. The basis of changes seen in the colloidal gold curve assay are not known but the first zone pattern described in this assay was probably a reflection of the presence of immunoglobulins in the CSF commonly seen in MS as well as in general paresis of syphilis.…”
mentioning
confidence: 99%