Statistische Untersuchungen zum Problem der Multiplen Sklerose

Abb, Lena; Schaltenbrand, Georg

doi:10.1007/bf00242550

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Intention or "ataxic" tremor, a frequent and disabling symptom of MS (Abb & Schaltenbrand, 1956;Calne & Klawans, 1977), i s one of the manifestations of a lesion to the cerebellum andor its ouflow tracts (Giesser, 1985;Calne & Klawans, 1977). Clinicopathologic correlates together with observations on animals subjected to experimental lesions (Mettler, 1955) suggest that the intention tremor of MS derives from a lesion of the cerbello-dentato-rubral pathway caudal to the red nucleus (Calne & Klawans, 1977).…”

Section: Discussionmentioning

confidence: 96%

Weak electromagnetic fields attenuate tremor in multiple sclerosis

Sandyk

Dann

1994

International Journal of Neuroscience

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It has been estimated that about 75% of patients diagnosed with multiple sclerosis (MS) have tremor which can be exceedingly disabling. The most common tremor observed in patients with MS is a cerebellar intention tremor ('kinetic tremor') although postural tremor ('static tremor') is also common and often extremely incapacitating. Currently there is no effective medical treatment for the tremor of MS which, in some severe cases, may be abolished by stereotactic thalamotomy. It was reported recently that extracranial application of brief AC pulsed electromagnetic fields (EMFs) in the picotesla (pT) range produced improvement in motor and cognitive functions in patients with MS. The present communication concerns three MS patients with a chronic progressive course of the disease (mean age: 39.3 +/- 8.3 years; mean duration of illness: 11.3 +/- 3.2 years) in whom brief external applications of pulsed EMFs of 7.5 pT intensity reduced intention and postural tremors resulting in significant functional improvement. The report suggests that these extremely low intensity EMFs are beneficial also in the treatment of tremors in MS and that this treatment may serve as an alternative method to stereotactic thalamotomy in the management of tremor in MS. The mechanisms by which EMFs attenuate the tremors of MS are complex and are thought to involve augmentation of GABA and serotonin (5-HT) neurotransmission in the cerebellum and its outflow tracts.

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Section: Discussionmentioning

confidence: 96%

Weak electromagnetic fields attenuate tremor in multiple sclerosis

Sandyk

Dann

1994

International Journal of Neuroscience

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“…The suggested causal relationship between MS and epilepsy has not been proved or disproved, although the general view is that the risk of epilepsy is increased. In most publications, the prevalence of epilepsy varies from 1-4% (Muller, 1949;Williams et al, 1952;Abb and Schaltenrand, 1956;Drake and Macrae, 1961;Kurtzke, 1970;Cendrowski and Majkowski, 1972;Elian and Dean, 1977), but figures up to 10% have been presented (Fuglsang-Frederiksen and Thygesen, 1952). These figures may be misleading in that, with one exception (Elian and Dean, 1977), they are based on clinical patient series.…”

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confidence: 99%

Prevalence and Prognosis of Epilepsy in Patients with Multiple Sclerosis

Kinnunen

Wikström

1986

Epilepsia

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An analysis of 599 clinically definite multiple sclerosis (MS) patients including all known cases of the southern province of Finland in January 1, 1979 revealed epileptic seizures in 21 (3.5%) patients. On that date, 12 patients needed treatment (2.0%). The age-adjusted prevalence of active epilepsy was significantly higher than that in the general population. The percentage of partial seizures (67%) was significantly increased in proportion to a series of 100 adult epilepsy patients, with a comparable age distribution. In 10 patients (including three patients with symptomatic epilepsy), the attacks appeared before the MS symptoms. The mean follow-up after the first seizures was 19.3 years. In 10 patients, the seizures disappeared totally during the surveillance until September 1985. Our results show an increased comorbidity between MS and epilepsy. In most cases, however, the prognosis of epilepsy was good and there seemed not to be any clear correlation between the severity of MS and epilepsy.

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“…It occurred only in 1.4% in the study of Muller (1949), in 3.8% in the cases of Abb and Schaltenbrand (1956) and in 6% of 812 cases in the study of Poser (1978), when hearing was tested clinically. The incidence of auditory dysfunction may be much higher when hearing is tested under ex perimental conditions; for a review see Noffsinger et al (1972).…”

Section: Discussionmentioning

confidence: 99%