Colloidal forming of macroporous calcium pyrophosphate bioceramics in 3D-printed molds

Filippov, Ya. Yu.; Orlov, Evgeny; Климашина, Е. С.; Евдокимов, П. В.; Сафронова, Т. В.; Putlayev, V.I.; Rau, Julietta V.

doi:10.1016/j.bioactmat.2020.02.013

Cited by 12 publications

(10 citation statements)

References 26 publications

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“…Calcium pyrophosphate was likewise composited with Ti-13Nb-13Zr alloy, demonstrating excellent mechanical and corrosion properties, high biocompatibility and bioactivity and, at the end, potential for orthopaedic implants [59]. Not least, the resorption simulation showed that the rate in the case of calcium pyrophosphate is lower than that for tricalcium phosphate and hydroxyapatite, which was associated with a weaker protonation of (P2O7) 4− ions during ceramic dissolution [60]. The microstructure of the as-prepared and heat-treated scaffolds is evidenced in the SEM images centralised in Figure 5,6.…”

Section: Resultsmentioning

confidence: 99%

Electrospun Fibre Webs Templated Synthesis of Mineral Scaffolds Based on Calcium Phosphates and Barium Titanate

et al. 2020

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The current work focuses on the development of mineral scaffolds with complex composition and controlled morphology by using a polymeric template in the form of nonwoven fibre webs fabricated through electrospinning. By a cross-linking process, gelatine fibres stable in aqueous solutions were achieved, these being further subjected to a loading step with two types of mineral phases: calcium phosphates deposited by chemical reaction and barium titanate nanoparticles as decoration on the previously achieved structures. Thus, hybrid materials were obtained and subsequently processed in terms of freeze-drying and heat treating with the purpose of burning the template and consolidating the mineral part as potential bone implants with improved biological response by external stimulation. The results confirmed the tunable morphology, as well as the considerable applicability of both as-prepared and final samples for the development of medical devices, which encourages the continuation of research in the direction of assessing the synergistic contribution of barium titanate domains polarisation/magnetisation by external applied fields.

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Section: Resultsmentioning

confidence: 99%

Electrospun Fibre Webs Templated Synthesis of Mineral Scaffolds Based on Calcium Phosphates and Barium Titanate

et al. 2020

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“…The slurry can be dried and sintered at high temperatures, simultaneously burning off the binder to obtain the ceramic scaffold. Filippov et al [60] proposed a low-pressure injection molding method, where ceramic slurry was cast into FDM-printed ABS molds under low pressure, and the ABS mold was burned off through hightemperature sintering, leaving the ceramic scaffolds in place. Furthermore, the team utilized DLP to print a Gyroid model, resulting in samples that were sintered to obtain a bioceramic scaffold with macropores [61].…”

Section: Introductionmentioning

confidence: 99%

Development of hybrid 3D printing approach for fabrication of high-strength hydroxyapatite bioscaffold using FDM and DLP techniques

Cheng,

Wu,

Tseng

et al. 2024

Biofabrication

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This study develops a hybrid 3D printing approach that combines fused deposition modeling (FDM) and digital light processing (DLP) techniques for fabricating bioscaffolds, enabling rapid mass production. The FDM technique fabricates outer molds, while DLP prints struts for creating penetrating channels. By combining these components, hydroxyapatite (HA) bioscaffolds with different channel sizes (600, 800, and 1000 μm) and designed porosities (10%, 12.5%, and 15%) are fabricated using the slurry casting method with centrifugal vacuum defoaming for significant densification. This innovative method produces high-strength bioscaffolds with an overall porosity of 32%–37%, featuring tightly bound HA grains and a layered surface structure, resulting in remarkable cell viability and adhesion, along with minimal degradation rates and superior calcium phosphate deposition. The HA scaffolds show hardness ranging from 1.43 to 1.87 GPa, with increasing compressive strength as the designed porosity and channel size decrease. Compared to human cancellous bone at a similar porosity range of 30%–40%, exhibiting compressive strengths of 13–70 MPa and moduli of 0.8–8 GPa, the HA scaffolds demonstrate robust strengths ranging from 40 to 73 MPa, paired with lower moduli of 0.7–1.23 GPa. These attributes make them well-suited for cancellous bone repair, effectively mitigating issues like stress shielding and bone atrophy.

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“…[6,7] The introduction of technologies represented by 3D printing technology created conditions for solving difficult problems such as complex/composite materials, the synergy of multiple tissues and organs, and personalized repair of specific parts. [8,9] The application of bioactive ceramics in bone tissue repair is increasing, and the introduction of new technologies/methods has generated various innovative devices.…”

Section: Introductionmentioning

confidence: 99%

Construction of Microfluidic Chip Structure for Cell Migration Studies in Bioactive Ceramics

Cao

et al. 2023

Small

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Cell migration is an essential bioactive ceramics property and critical for bone induction, clinical application, and mechanism research. Standardized cell migration detection methods have many limitations, including a lack of dynamic fluid circulation and the inability to simulate cell behavior in vivo. Microfluidic chip technology, which mimics the human microenvironment and provides controlled dynamic fluid cycling, has the potential to solve these questions and generate reliable models of cell migration in vitro. In this study, a microfluidic chip is reconstructed to integrate the bioactive ceramic into the microfluidic chip structure to constitute a ceramic microbridge microfluidic chip system. Migration differences in the chip system are measured. By combining conventional detection methods with new biotechnology to analyze the causes of cell migration differences, it is found that the concentration gradients of ions and proteins adsorbed on the microbridge materials are directly related to the occurrence of cell migration behavior, which is consistent with previous reports and demonstrates the effectiveness of the microfluidic chip model. This model provides in vivo environment simulation and controllability of input and output conditions superior to standardized cell migration detection methods. The microfluidic chip system provides a new approach to studying and evaluating bioactive ceramics.

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Colloidal forming of macroporous calcium pyrophosphate bioceramics in 3D-printed molds

Cited by 12 publications

References 26 publications

Electrospun Fibre Webs Templated Synthesis of Mineral Scaffolds Based on Calcium Phosphates and Barium Titanate

Electrospun Fibre Webs Templated Synthesis of Mineral Scaffolds Based on Calcium Phosphates and Barium Titanate

Development of hybrid 3D printing approach for fabrication of high-strength hydroxyapatite bioscaffold using FDM and DLP techniques

Construction of Microfluidic Chip Structure for Cell Migration Studies in Bioactive Ceramics

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