Collision tumour of squamous cell carcinoma and invasive malignant melanoma of scalp – a case report

Mopuri, Nabi; Laitung, J.K.G.; Cardozo, Claribel

doi:10.1016/j.bjps.2008.07.033

Cited by 12 publications

(17 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combinations of SCC with melanoma or MCC are most well known [30, 31]. The practical importance is that on finding a prominent SCC component, the coexistence of a potentially more aggressive tumor, or a tumor that may require specific adjuvant therapy, should be sought for.…”

Section: Collision Tumorsmentioning

confidence: 99%

Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation

Tan

et al. 2013

Journal of Skin Cancer

View full text Add to dashboard Cite

Squamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy. On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinization, and invasive features. Diagnostic challenges may occasionally arise, especially in the setting of small punch biopsies or superficial shave biopsies, where only part of the lesion may be assessable by the pathologist. Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma. The careful application of time-honored diagnostic criteria, close clinicopathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis. This review aims to present the key differential diagnoses of SCC, to discuss common diagnostic pitfalls, and to recommend ways to deal with diagnostically challenging cases.

show abstract

Section: Collision Tumorsmentioning

confidence: 99%

Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation

Tan

et al. 2013

Journal of Skin Cancer

View full text Add to dashboard Cite

show abstract

“…It is also hypothesized that a collision tumor can arise synchronously from the localized action of a carcinogen on two adjacent cell lines (2)(3). A metachronous collision tumor can develop if one neoplasm creates a microenvironment that enhances the presence of the other neoplasm through paracrine effects or attracting metastasis (4)(5)(6). Paracrine effects may involve a change in blood flow, oxygen tension, stem cell differentiation, or local immune function (7).…”

Section: Discussionmentioning

confidence: 99%

Management of a Novel Parotid Collision Tumor

et al. 2011

View full text Add to dashboard Cite

INTRODUCTION DISCUSSION ABSTRACTEducational Objective: At the conclusion of this presentation, the participants should be able to define "collision tumor", describe a novel collision tumor of the parotid, and discuss the complexity in managing similar unexpected operative findings.Objectives: 1) To present a novel collision tumor of the parotid gland: concurrent squamous cell carcinoma and small cell lymphoma; and 2) to analyze the operative approach to collision tumors.Study Design: Case report. Abridged Case History:A 75 year old male with left ear lobule melanoma was concurrently found to have a right parotid mass. Pre-operative CT showed a right parotid mass and all FNA attempts were non-diagnostic. The patient was taken to the operating room for excision of the left ear melanoma, as well as for right superficial parotidectomy and right modified neck dissection. The operation was complicated by frozen pathology suggestive of a novel collision tumor.

show abstract

Section: Introductionmentioning

confidence: 99%

“…The presence of two independent neoplasms occurring at the same cutaneous lesion is not uncommon . The collision of squamous cell carcinoma (SCC) and malignant melanoma is a rather unusual manifestation with only a handful of cases reported in the literature . The coexistence of these two distinct tumours has been documented in oral and genital mucosa, facial skin, old scars and xeroderma pigmentosum .…”

Section: Introductionmentioning

confidence: 99%

“…The collision of squamous cell carcinoma (SCC) and malignant melanoma is a rather unusual manifestation with only a handful of cases reported in the literature . The coexistence of these two distinct tumours has been documented in oral and genital mucosa, facial skin, old scars and xeroderma pigmentosum . The pathogenesis and biological potential of collision tumours remains controversial .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Symbiotic collision tumour of the scalp: squamous cell carcinoma and malignant melanoma

et al. 2019

View full text Add to dashboard Cite

Cutaneous collision tumours are the co-existence of two tumours of different histopathological morphologies that coincide at the same or adjacent anatomical sites. A large scalp nodule excised from a 70 year-old man revealed a collision tumour composed of cells of squamous carcinoma (SCC) and malignant melanoma. Immunohistochemistry using dual staining for melanoma and squamous cell carcinoma demonstrated an unusual pattern; nests of melanoma cells surrounded by a layer of squamous carcinoma cells. The unique architecture observed in the case suggested a relationship between the two tumours.

show abstract

Collision tumour of squamous cell carcinoma and invasive malignant melanoma of scalp – a case report

Cited by 12 publications

References 5 publications

Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation

Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation

Management of a Novel Parotid Collision Tumor

Symbiotic collision tumour of the scalp: squamous cell carcinoma and malignant melanoma

Contact Info

Product

Resources

About