Collective timekeeping among cells of the master circadian clock

Evans, Jennifer

doi:10.1530/joe-16-0054

Cited by 59 publications

(74 citation statements)

References 326 publications

(439 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although previous publications implicated astrocytes in SCN function (reviewed in [18, 19]), we lacked the tools to target these glial cells directly. Using promoters for GFAP and Aldh1L1 to drive reporters and manipulate clock genes, we were able to control astrocytes specifically within the SCN in vivo and in vitro .…”

Section: Discussionmentioning

confidence: 99%

Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior

et al. 2017

View full text Add to dashboard Cite

Summary Astrocytes are active partners in neural information processing [1, 2]. However, the roles of astrocytes in regulating behavior remain unclear [3, 4]. Because astrocytes have persistent circadian clock gene expression and ATP release in vitro [5–8], we hypothesized that they regulate daily rhythms in neurons and behavior. Here we demonstrated that daily rhythms in astrocytes within the mammalian master circadian pacemaker, the suprachiasmatic nucleus (SCN), determine the period of wheel-running activity. Ablating the essential clock gene, Bmal1, specifically in SCN astrocytes lengthened the circadian period of clock gene expression in the SCN and in locomotor behavior. Similarly, excision of the short-period CK1ε tau mutation specifically from SCN astrocytes resulted in lengthened rhythms in the SCN and behavior. These results indicate that astrocytes within the SCN communicate to neurons to determine circadian rhythms in physiology and in rest-activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior

et al. 2017

View full text Add to dashboard Cite

show abstract

“…There are a number of excellent reviews of SCN neuroanatomy that discuss the issues related to SCN subdivisions, so we provide only a brief background and discussion here (Moore et al, 2002; Hastings and Herzog, 2004; Lee et al, 2003; Antle et al, 2009; Morin, 2007; Antle and Silver, 2005; Yan et al, 2007; Yan, 2009; Evans, 2016; Evans and Gorman, 2016). Historically, each side of the bilaterally paired SCN has been divided into two regions (although a third division has been described as well) (Morin, 2007).…”

Section: Suprachiasmatic Nucleus (Scn): Functional Anatomical Anmentioning

confidence: 99%

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

Albers

Walton

Gamble

et al. 2017

Frontiers in Neuroendocrinology

133

View full text Add to dashboard Cite

Virtually every neuron within the suprachiasmatic nucleus (SCN) communicates via GABAergic signaling. The extracellular levels of GABA within the SCN are determined by a complex interaction of synthesis and transport, as well as synaptic and non-synaptic release. The response to GABA is mediated by GABAA receptors that respond to both phasic and tonic GABA release and that can produce excitatory as well as inhibitory cellular responses. GABA also influences circadian control through the exclusively inhibitory effects of GABAB receptors. Both GABA and neuropeptide signaling occur within the SCN, although the functional consequences of the interactions of these signals are not well understood. This review considers the role of GABA in the circadian pacemaker, in the mechanisms responsible for the generation of circadian rhythms, in the ability of non-photic stimuli to reset the phase of the pacemaker, and in the ability of the day-night cycle to entrain the pacemaker.

show abstract

“…External cues from the environment such as light enter the retina, leading to downstream signaling in which AVP is an output signal of the master circadian clock of the suprachiasmatic nucleus (SCN), as it has traditionally been viewed [64]. However, it has been suggested recently that AVP may play a more direct role in synchronizing the circadian network [65]. AVP is stored in the posterior pituitary gland until a number of different factors, such as plasma osmolality, hypotension, or hypovolemia, stimulate its release [66].…”

Section: Circadian Rhythms Along the Nephronmentioning

confidence: 99%

Circadian regulation of renal function

Johnston

Pollock

2018

Free Radical Biology and Medicine

View full text Add to dashboard Cite

The kidneys regulate many vital functions that require precise control throughout the day. These functions, such as maintaining sodium balance or regulating arterial pressure, rely on an intrinsic clock mechanism that was commonly believed to be controlled by the central nervous system. Mounting evidence in recent years has unveiled previously underappreciated depth of influence by circadian rhythms and clock genes on renal function, at the molecular and physiological level, independent of other external factors. The impact of circadian rhythms in the kidney also affects individuals from a clinical standpoint, as the loss of rhythmic activity or clock gene expression have been documented in various cardiovascular diseases. Fortunately, the prognostic value of examining circadian rhythms may prove useful in determining the progression of a kidney-related disease, and chronotherapy is a clinical intervention that requires consideration of circadian and diurnal rhythms in the kidney. In this review, we discuss evidence of circadian regulation in the kidney from basic and clinical research in order to provide a foundation on which a great deal of future research is needed to expand our understanding of circadian relevant biology.

show abstract

Collective timekeeping among cells of the master circadian clock

Cited by 59 publications

References 326 publications

Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior

Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

Circadian regulation of renal function

Contact Info

Product

Resources

About