Collection of airborne ultrafine cellulose nanocrystals by impinger with an efficiency mimicking deposition in the human respiratory system

Roberts, Rose; Gettz, Kevin Paul; Stebounova, Larissa V.; Shatkin, Jo Anne; Peters, Thomas M.; Foster, E. Johan

doi:10.1080/15459624.2018.1540876

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…Although some methods and standards have been developed to measure other nanomaterials, the detection of CNs remains a challenge. Some approaches to detecting and labelling CNs have been developed, including the use of particle counters, electron microscopy, carbon analysis and gas chromatography with mass spectrometry, and fluorescence- and radio-labeling [ 251 , 259 , 260 , 261 , 262 , 263 ]. Improved detection of CNs will support more accurate calculation of their release from consumer products and in occupational settings.…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Review on Hybrid Reinforced Polymer Matrix Composites with Nanocellulose, Nanomaterials, and Other Fibers

et al. 2023

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The use of composite materials has seen many new innovations for a large variety of applications. The area of reinforcement in composites is also rapidly evolving with many new discoveries, including the use of hybrid fibers, sustainable materials, and nanocellulose. In this review, studies on hybrid fiber reinforcement, the use of nanocellulose, the use of nanocellulose in hybrid forms, the use of nanocellulose with other nanomaterials, the applications of these materials, and finally, the challenges and opportunities (including safety issues) of their use are thoroughly discussed. This review will point out new prospects for the composite materials world, enabling the use of nano- and micron-sized materials together and creating value-added products at the industrial scale. Furthermore, the use of hybrid structures consisting of two different nano-materials creates many novel solutions for applications in electronics and sensors.

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Section: Challenges and Opportunitiesmentioning

confidence: 99%

Review on Hybrid Reinforced Polymer Matrix Composites with Nanocellulose, Nanomaterials, and Other Fibers

et al. 2023

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“…There is a necessity for a toxicity study of the ultrafine cellulose nanocrystals preventing pulmonary infection. 294 Composite NPs of poly(lactic-coglycolic acid) (PLGA) and polyethylene (PEI) are indeed an excellent option for liposomal and viral vectors for the pulmonary delivery of plasmid DNA. The in vitro cell uptake study was conducted on the CFBE41o-cell line and confirmed that NPs with 10% w/w PEI were more effective but exhibited strong cytotoxicity in MTT assays, threatening the safety of this formulation.…”

Section: Toxicity Of Inhaled Nanoparticlesmentioning

confidence: 99%

“…Due to the very fine size limits of the cellulose nanocrystals, it can be impregnated with Rhodamine b and visualized via transmission electron microscopy (TEM) and dynamic light scattering (DLS). There is a necessity for a toxicity study of the ultrafine cellulose nanocrystals preventing pulmonary infection . Composite NPs of poly(lactic- co -glycolic acid) (PLGA) and polyethylene (PEI) are indeed an excellent option for liposomal and viral vectors for the pulmonary delivery of plasmid DNA.…”

Section: Toxicity Of Inhaled Nanoparticlesmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery System: The Magic Bullet for the Treatment of Chronic Pulmonary Diseases

Pramanik

Mohanto

Manne³

et al. 2021

Mol. Pharmaceutics

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Chronic pulmonary diseases encompass different persistent and lethal diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), asthma, and lung cancers that affect millions of people globally. Traditional pharmacotherapeutic treatment approaches (i.e., bronchodilators, corticosteroids, chemotherapeutics, peptide-based agents, etc.) are not satisfactory to cure or impede diseases. With the advent of nanotechnology, drug delivery to an intended site is still difficult, but the nanoparticle’s physicochemical properties can accomplish targeted therapeutic delivery. Based on their surface, size, density, and physical-chemical properties, nanoparticles have demonstrated enhanced pharmacokinetics of actives, achieving the spotlight in the drug delivery research field. In this review, the authors have highlighted different nanoparticle-based therapeutic delivery approaches to treat chronic pulmonary diseases along with the preparation techniques. The authors have remarked the nanosuspension delivery via nebulization and dry powder carrier is further effective in the lung delivery system since the particles released from these systems are innumerable to composite nanoparticles. The authors have also outlined the inhaled particle’s toxicity, patented nanoparticle-based pulmonary formulations, and commercial pulmonary drug delivery devices (PDD) in other sections. Recently advanced formulations employing nanoparticles as therapeutic carriers for the efficient treatment of chronic pulmonary diseases are also canvassed.

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“…Besides the above-mentioned in vitro experiment, more studies focused on the health concerns of CNCs for the human body. Roberts et al (Roberts et al 2019) pointed out that it was crucial to monitor the CNC concentration in the air because CNCs might enter the body through inhalation. suggested that the study of the CNC orogastrointestinal process was significant toward understanding the associated safety issues.…”

Section: Safety Issuesmentioning

confidence: 99%

Recent developments and prospective food-related applications of cellulose nanocrystals: a review

et al. 2020

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Collection of airborne ultrafine cellulose nanocrystals by impinger with an efficiency mimicking deposition in the human respiratory system

Cited by 6 publications

References 28 publications

Review on Hybrid Reinforced Polymer Matrix Composites with Nanocellulose, Nanomaterials, and Other Fibers

Review on Hybrid Reinforced Polymer Matrix Composites with Nanocellulose, Nanomaterials, and Other Fibers

Nanoparticle-Based Drug Delivery System: The Magic Bullet for the Treatment of Chronic Pulmonary Diseases

Recent developments and prospective food-related applications of cellulose nanocrystals: a review

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