Collagenous colitis: A case report and review of the literature

Microscopic colitis: Common cause of unexplained nonbloody diarrhea

“…As the mucosa is not ulcerated or otherwise disrupted, the diarrhea generally does not contain blood or pus [32] . The diarrhea in collagenous colitis is likely due to inflammatory process and sub epithelial collagen serves as a cofactor in the role of a diffusion barrier and increased levels of immunoreactive prostaglandins E2 in stool water may lead to secretary diarrhea.…”

“…The diarrhea in collagenous colitis is likely due to inflammatory process and sub epithelial collagen serves as a cofactor in the role of a diffusion barrier and increased levels of immunoreactive prostaglandins E2 in stool water may lead to secretary diarrhea. Some cases may have fibrosis due to increased mucosal secretion of vascular endothelial growth factor [32,33] . One important question is how many biopsies need to be taken and how many biopsies are needed to confirm or rule out microscopic colitis.…”

Collagenous Colitis: A Clinicopathological Review

“…However, one patient has been de scribed [6] as having benefited from a course of mepacrine hydrochloride with subsequent follow-up biopsy showing disappearance of the collagenous deposit. Another patient has been reported [12] as having been symptomfree for 1 year following treatment with co deine phosphate and mebeverine hydrochlo ride, the follow-up biopsy showing a substan tial decrease of the collagenous thickening. However, the patient subsequently showed recurrence of the histological lesion and symptoms [12], Regarding the actual thickness of the col lagenous deposit seen histologically in cases of collagenous colitis, somewhat widely dif ferent figures have been quoted, with ex tremes of 7-60 pm.…”

“…Another patient has been reported [12] as having been symptomfree for 1 year following treatment with co deine phosphate and mebeverine hydrochlo ride, the follow-up biopsy showing a substan tial decrease of the collagenous thickening. However, the patient subsequently showed recurrence of the histological lesion and symptoms [12], Regarding the actual thickness of the col lagenous deposit seen histologically in cases of collagenous colitis, somewhat widely dif ferent figures have been quoted, with ex tremes of 7-60 pm. There may be several reasons for this discrepancy: (1) The deposit of collagen along the length of the affected colorectal mucosa is probably uneven in any given patient and may also differ from one patient to another.…”

“…Col lagenous colitis was first recognized in 1976 by Lindström [1] who believed that the wa tery diarrhea was a result of the collagenous deposit and consequently coined the term 'collagenous colitis'. Since 1980, a number of additional case reports of collagenous colitis have been published [2][3][4][5][6][7][8][9][10][11][12], as well as one editorial [13] and some lively correspon dence [14. 15] on the subject.…”