Colonic carcinoma associated with an abnormal collagen table: Collagenous colitis

Gardiner, Geoffrey W.; Goldberg, Robert B.; Currie, D C; Murray, D.

doi:10.1002/1097-0142(19841215)54:12<2973::aid-cncr2820541227>3.0.co;2-f

Cited by 37 publications

(17 citation statements)

References 13 publications

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“…Perturbations in antioxidant status, oxidative stress and aberrant collagen production are associated with colon pathologies [1][2][3]14,15]. Oxidative stress induced by dietary vitamin E deficiency in this study was not reflected by major changes in the expression of the 207 genes screened using the stress gene array.…”

Section: Discussionmentioning

confidence: 56%

Oxidative stress in colon tissue induced by vitamin E depletion

Drew¹,

Mercer²,

Mayer³

et al. 2004

Biochemical Society Transactions

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Inflammatory disorders of the bowel and colon cancer are associated with elevated indices of oxidative stress. Analogous elevations in markers of oxidative stress and loss of cell-membrane integrity are also observed in the colons of rats deficient in vitamin E (D-alpha-tocopherol), the major lipid-soluble antioxidant in biological systems. The causal relationship between colon pathologies associated with oxidative stress and dietary deficiency in antioxidant vitamins such as vitamin E is still uncertain. Investigation of potential mechanisms by which lack of dietary vitamin E may lead to clinically relevant pathological changes in colon tissue was conducted using gene expression profiling strategies on vitamin E-sufficient and -deficient rats. Morphological changes and increased indices of lipid peroxidation were linked to vitamin E deficiency. These changes in colon tissue are potentially important in disease pathogenesis of the colon linked with oxidative stress or other direct consequences of inadequate levels of vitamin E.

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Section: Discussionmentioning

confidence: 56%

Oxidative stress in colon tissue induced by vitamin E depletion

Drew¹,

Mercer²,

Mayer³

et al. 2004

Biochemical Society Transactions

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“…A particularly striking finding, to date, is the rarity of reported malignant disease complicating the clinical course of collagenous colitis. Colorectal cancer has been noted [10,29] , including cecal cancer [30] , but these may have been only coincidental. In an extensive survey study, the overall risk of colorectal cancer was similar to the general control population; only 2 patients with collagenous colitis were seen with colorectal cancer, but these occurred before development of colitis [31] .…”

Section: Complicationsmentioning

confidence: 99%

Complications of collagenous colitis

Freeman

2008

WJG

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“…Usually the change is apparent in a rectal biopsy, although not always. 22 The course of the illness is variable: some patients have chronic persistent diarrhoea'4; some have relapses and remissions"'3; and a few have apparent spontaneous resolution either with7' or without'"2 disappearance of the abnormal collagen band. Conventional medical treatment is usually ineffective,'2 although there are reports of improvement with metronidazole,"29 mepacrine,' prednisolone,'0'3 sulphasalazine," 26 and loperamide" and also with the homoeopathic remedy Natrum Mur.…”

Section: Collagenous Colitis: Disease or Diversion?mentioning

confidence: 99%